Periostin mediates epithelial-mesenchymal transition through the MAPK/ERK pathway in hepatoblastoma-中国期刊网

摘要 Objective:Theaimofthepresentstudywastoanalyzetheprognosticfactorsinpatientswithhepatoblastoma(HB)inoursinglecenterandtoevaluateperiostin(POSTN)expressioninHBanditsassociationwithclinicopathologicalvariables.Inaddition,theunderlyingmechanismofhowPOSTNpromotesHBprogressionwasdiscussed.Methods:POSTNexpressionwasinvestigatedinHBtumorsbyimmunohistochemistry(IHC),immunofluorescence(IF)andWesternblot(WB).TheassociationamongPOSTNexpression,clinicopathologicalfeaturesandoverallsurvival(OS)wasalsoevaluated.ThemigrationandadhesionabilityofHBcellsweremeasuredusingchemotaxisandcell-matrixadhesionassays,respectively.Epithelial-mesenchymaltransition(EMT)-associatedmarkersandactivationoftheERKpathwayweredetectedbyWB.Results:HBpatientshadpoorprognosiswhichdisplayedlymphnodemetastasis,vascularinvasion,POSTNandvimentinexpression.POSTNexpressionwasalsoassociatedwithlymphnodemetastasis.Furthermore,overexpressedPOSTNpromotedmigrationandtheadhesiveabilityofHBcellsinvitro.Inaddition,wedemonstratedthatPOSTNactivatedtheMAPK/ERKpathway,upregulatedtheexpressionofSnailanddecreasedtheexpressionofOVOL2.Finally,POSTNpromotedtheexpressionofEMT-associatedmarkers.Conclusions:POSTNmightmodulateEMTviatheERKsignalingpathway,therebypromotingcellularmigrationandinvasion.OurstudyalsosuggeststhatPOSTNmayserveasatherapeuticbiomarkerinHBpatients.

1Rui Zhang;You-Heng Wei;Chun-Yan Zhao;Hong-Yuan Song;Ni Shen;Xiao Cui;Xin Gao;Zhong-Tian Qi;Ming Zhong;Wei Shen. EDIL3 depletion suppress epithelial-mesenchymal transition of lens epithelial cells via transforming growth factor β pathway.眼科,2018-01.
2Fan Yu,Song Tu-Run,Wei Qiang,Yang Lu,Lin Tao,Feng Xiao-Bing,Wang Xian-Ding,Huang Zhong-Li,Feng Shi-Jian. Modulatory effect of aquaporin 5 on estrogen-induced epithelial-mesenchymal transition in prostate epithelial cells.医药卫生,2021-03.
3Tang Kai-Wen,Guo Zhe-Xu,Wu Zhong-Hua,Zhou Cen,Sun Jie,Wang Xin,Song Yong-Xi,Wang Zhen-Ning. Circ_0049447 acts as a tumor suppressor in gastric cancer through reducing proliferation, migration, invasion, and epithelial-mesenchymal transition.医药卫生,2021-06.
4Hu Wentao;Pei Hailong;Sun Fang;Li Pengfei;Zhou Guangming. 3 - 90 Radiation Induced Bystander Effects Promote Epithelial-Mesenchymal Transition in Mouse Lungs.物理,2013-01.
5Xiong Xin-Rong,Tian Xin-Li,Huo Ru-Jie,Dong Yan-Ting,Liu Dai,Bai Jing-Cui,Qi Yun-Feng,Tian Xin-Rui. 1α, 25-dihydroxyvitamin D3 inhibits transforming growth factor β1-induced epithelial-mesenchymal transition via β-catenin pathway.医药卫生,2020-08.
6Yihao Wu,Zhi Zhang,Zhe Chen,Chen Fu,Lu Huang,Jiabing Wang,Jian Li,Andrew Barszczyk,Deye Yang. MicroRNA-29b suppresses TGF-β-induced epithelial-mesenchymal transition in renal interstitium of spontaneously hypertensive rats.医药卫生,2022-12.
7Xianjue Wang,Ping Wei,Ling Yang,Fangyuan Liu,Xin Tong,Xiaoyu Yang,Liya Su. MicroRNA-20a-5p regulates the epithelial-mesenchymal transition of human hepatocellular carcinoma by targeting RUNX3.医药卫生,2022-12.
8YANG,Dancheng. The Mechanism of Long Non-Coding RNA SNHG7 in Cholangiocarcinoma Cell Proliferation,Migration,and Epithelial-Mesenchymal Transition.,2023-03.
9He Juan,Jiang Ya-Li,Wang Yan,Tian Xiu-Juan,Sun Shi-Ren. Micro-vesicles from mesenchymal stem cells over-expressing miR-34a inhibit transforming growth factor-β1-induced epithelial-mesenchymal transition in renal tubular epithelial cells in vitro.医药卫生,2020-08.
10Aniket V.Mali;Asavari A.Joshi;Mahabaleshwar V.Hegde;Shivajirao S.Kadam. Enterolactone modulates the ERK/NF-κB/Snail signaling pathway in triple-negative breast cancer cell line MDA-MB-231 to revert the TGF-β-induced epithelial–mesenchymal transition.肿瘤,2018-02.

Periostin mediates epithelial-mesenchymal transition through the MAPK/ERK pathway in hepatoblastoma

来源期刊

相关推荐

同分类资源更多

相关关键词

Periostin mediates epithelial-mesenchymal transition through the MAPK/ERK pathway in hepatoblastoma

来源期刊

相关推荐

同分类资源 更多

相关关键词

同分类资源更多