Effect of Activation-induced Cell Death of Peripheral Blood Mononuclear cells in Patients with Condyloma Acuminatum-中国期刊网

摘要 Objective:Toinvestigatetheeffectofactivation-in-ducedcelldeath(AICD)oncellularimmunefunctioninthecondylomaacuminatum(CA).Methods:Peripheralbloodmononuclearcells(PBMC)wereisolatedfromnormalhealthyindividuals(controlgroup)andpatientswithCA.PBMCwereculturedwithPHA-Pfor48hinvitro.ApoptosisofthePBMCwasdetectedbyflowcytometry.Supernatantcytokines(IL-2andIL-10)wereassayedbyELISA.Results:TherateofPBMCapoptosisinbothCAgroupandcontrolgroupinfreshPBMCwasverylowandsimilarinbothgroups(P>0.05).TherateofPBMCapoptosiswithintheCAgroupwasnoticeablyincreasedcomparedtothatofthecontrol(P<0.001)afterPBMCwereculturedfor48h.ThelevelofIL-2wassignificantlylowerintheCAgroupthaninthecontrolgroup(P<0.001),ThelevelofIL-10wassignificantlyhigherintheCAgroupcomparedtothecontrolgroup(P<0.001).Conclusion:StudyresultsindicatethatAICDmayaffectcellularmediatedimmunefunctionandplayanimportantroleinthepathogenesisofCA.

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Effect of Activation-induced Cell Death of Peripheral Blood Mononuclear cells in Patients with Condyloma Acuminatum

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Effect of Activation-induced Cell Death of Peripheral Blood Mononuclear cells in Patients with Condyloma Acuminatum

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