Proteomics Reveals that Proteins Expressed During the Early Stage of Bacillus anthracis Infection Are Potential Targets for the Development of Vaccines and Drugs-中国期刊网

摘要 Inthisreview,weadvanceanewconceptindevelopingvaccinesand/ordrugstotargetspecificproteinsexpressedduringtheearlystageofBacillusanthracis(anthrax)infectionandaddressexistingchallengestothisconcept.Threeproteins(immuneinhibitorA,GPR-likesporeprotease,andalanineracemase)initiallyidentifiedbyproteomicsinourlaboratorywerefoundtohavedifferentialexpressionsduringanthraxsporegerminationandearlyoutgrowth.Otherstudiesofdifferentbacillusstrainsindicatethatthesethreeproteinsareinvolvedineithergerminationorcytotoxicityofspores,suggestingthattheymayserveaspotentialtargetsforthedesignofanti-anthraxvaccinesanddrugs.

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Proteomics Reveals that Proteins Expressed During the Early Stage of Bacillus anthracis Infection Are Potential Targets for the Development of Vaccines and Drugs

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Proteomics Reveals that Proteins Expressed During the Early Stage of Bacillus anthracis Infection Are Potential Targets for the Development of Vaccines and Drugs

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