摘要
摘要目的探讨姑息切除联合化疗治疗有并发症的晚期胃癌的临床疗效.方法回顾性收集我院２０１０年１月至２０１４年１２月收治的４２例并发出血或幽门梗阻等并发症的晚期胃癌,接受姑息性切除手术和改良DCF方案化疗,至少完成２个周期治疗后评估临床疗效及不良反应,并通过随访观察患者长期生存时间.结果９例患者行姑息性全胃切除术,３３例行姑息性远端胃切除术.术后行改良DCF方案化疗３~１１周期,不良反应主要为骨髓抑制、脱发及恶心、呕吐等胃肠道反应.中位生存时间为１４．１个月,１年生存率为６１．１％,３年生存率为２０．５％.结论对于并发出血、幽门梗阻的晚期胃癌,姑息性切除术后联合改良DCF方案化疗具有较好临床疗效,毒副反应可以耐受.关键词晚期胃癌;姑息手术;改良DCF方案AbstractobjectiveToinvestigatetheclinicvalueofpalliativegastrectomycombinedwithchemotherapyforadvancedgastriccancer．MethodsFromJanuary２０１０toNovember２０１４,atotalof４２patientswhounderwentpalliativegastrectomyduetopyloricobstructionorbleedingcombinedwithmodifiedDCFregimechemotherapyfoadＧvancedgastriccancerinourhospital．Eachpatientreceivedatleast２cyclesofthetreatment,andtheefficacyandtoxicitieswereevaluatedaftertreatment．Thelong－termoＧverallsurvivalswereevaluatedbyfollow－up．Results９patientswereperformedpalliativetotalgastrecomyand３３patientswereperformeddistalsub－gastrectomy,respecＧtively,receiving３to１１cyclesofmodifiedDCFregimeaftersurgery．ConclusionsForadvancedgastriccancercombinedwithcomplicationssuchaspyloricobstructionandbleedinKge,ypwalolriadtsivegastrectomycombinedwithmodifiedDCFregimechemotherapyisefficaciousandthetoxicitiesaretolerable．Advancedgastriccancer;Palliativegastrectomy;modifiedDCFregime中图分类号R７３５．２文献标识码B文章编号１００８－６３１５(２０１５)１２－１３４２－０１
出版日期
2015年12月22日（中国期刊网平台首次上网日期，不代表论文的发表时间）
