摘要
AbstractObjective:Neurosyphilis is challenging to diagnose, especially in patients with human immunodeficiency virus (HIV)/syphilis co-infection. The aim of this study was to profile the clinical features of neurosyphilis and evaluate the correlation between neurosyphilis and clinical or laboratory factors among patients with HIV/syphilis co-infection.Methods:We retrospectively analyzed the data of 479 HIV/syphilis co-infected patients examined between August 2009 and September 2018. A multivariate logistic regression model was used to identify factors correlated with neurosyphilis.Results:The overall prevalence of neurosyphilis was 21.7%. The prevalence of neurosyphilis differed among patients with primary (11.1%), secondary (20.1%), and latent syphilis (29.1%). The prevalences of neurosyphilis in patients with serological non-response and serofast patients were 26.1% and 6.3%, respectively, while 12.5% of patients with serological relapse had neurosyphilis. Patients with secondary and latent syphilis had serum rapid plasma reagin (RPR) titers (per unit) of 1.44-fold [95% confidence interval (CI): 1.08-1.93, P= 0.014] and 2.73-fold (95% CI: 1.49-5.00, P= 0.001), respectively, which increased the risk of confirmed neurosyphilis. Among patients with latent syphilis, a serum RPR titer of ≥1:32 and peripheral blood CD4 cell count of ≤350/mL were significantly associated with neurosyphilis, with adjusted odds ratios of 9.45 (95% CI: 1.86-48.03, P= 0.007) and 3.75 (95% CI: 1.11-12.66, P= 0.033), respectively.Conclusion:A serum RPR titer of ≥1:32 and a peripheral blood CD4 cell count of ≤350/mL have predictive value in screening for neurosyphilis among HIV-positive patients with latent syphilis.
机构地区
Sexually Transmitted Disease Institute, Shanghai Skin Disease Hospital, Clinical School of Anhui Medical University, Shanghai 200050, China,Sexually Transmitted Disease Institute, Shanghai Skin Disease Hospital, Tongji University, School of Medicine, Shanghai 200050, China,China-Australia Joint Rese
出版日期
2022年12月13日（中国期刊网平台首次上网日期，不代表论文的发表时间）
