摘要
AnewmethodforsimulatingthefoldingpathwayofRNAsecondarystructureusingthemodifiedantcolonyalgorithmisproposed.ForagivenRNAsequence,thesetofallpossiblestemsisobtainedandtheenergyofeachstemiscalculatedandstoredattheinitialstage.Furthermore,amorerealisticformulaisusedtocomputetheenergyofmulti-branchloopinthefollowingiteration.Thenafoldingpathwayissimulated,includingsuchprocessesasconstructionoftheheuristicinformation,theruleofinitializingthepheromone,themechanismofchoosingtheinitialandnextstemandthestrategyofupdatingthepheromonebetweentwodifferentstems.FinallybytestingRNAsequenceswithknownsecondarystructuresfromthepublicdatabases,weanalyzetheexperimentaldatatoselectappropriatevaluesforparameters.ThemeasureindexesshowthatourprocedureismoreconsistentwithphylogeneticallyprovenstructuresthansoftwareRNAstructuresometimesandmoreeffectivethanthestandardGeneticAlgorithm.
出版日期
2010年04月14日（中国期刊网平台首次上网日期，不代表论文的发表时间）
