Effect of valsartan on Lectin-like oxidized-low density lipoprotein receptor-1 expression in balloon-injured rat aorta-中国期刊网

摘要 BackgroundIt'sestablishedthatLectin-likeoxidizedlow-densitylipoproteinreceptor-1(LOX-1)isinvolvedinintimalhyperplasiaafterballooninjury.Therecentevidencealsosuggeststhatvalsartanhasanantiatheroscleticeffect.Inthisstudy,theexpressionofLOX-1andtheeffectofvalsartanonitsexpressionwasinvestigatedinrataortaafterballooninjury.MethodsRatmodelofaorticendothelialdenudationwasinducedby2Fballooncatheter.Ratswererandomlydividedintothreegroups:control,operationandvalsartantreatment.Theaortictissuesweretakenfromratsineachgroupondays14and28aftersurgery.ThethicknessofvascularwallwasmeasuredwithHEstain,LOX-1mRNAandproteinweredeterminedbyreversetranscription-polymersechainreaction(RT-PCR)andimmunohistochemistry,respectively.ResultsComparedwiththecontrolgroup,significantintimalthickeningwasobservedatday14and28afterinjury.Comparedwiththeoperationgroup,intimalthicknessofeachtimepointwassignificantlydecreasedinvalsartantreatmentgroup.Atday14and28afterballooninjury,theexpressionlevelsofLOX-1mRNAandproteinweresignificantlyincreased,andweregreatlydecreasedaftervalsartantreatment.ConclusionsTheexpressionofLOX-1isincreasedafterendothelialinjury.Valsartaninhibitsaorticintimalthickeninginducedbyendothelialdenudation,whichisassociatedwiththedownregulationofLOX-1expression.

1Zhao Xiang,Tang Bin,Shi Zhi-Hua,Deng Zi-Wei,Deng Ye,Tan Li-Ming,Jiang Shi-Long,Shu Yuan-Lu,Qiu Cheng-Feng. Asialoglycoprotein receptor 1 gene expression in peripheral blood monocytes associates with serum total cholesterol and low-density lipoprotein cholesterol levels.医药卫生,2020-08.
2HUI LING BAI;YUAN FANG MA;WEN ZHI TIAN;HSIOU-CHI LIOU. Molecular cloning and chracterization of a c-Rel induced lectin-like receptor and its alternative splice isoforms.基础医学,2005-04.
3LIU Ping LI Yong-hong CAI Shang-lang. Effect of rosuvastatin on expression of angiotensin Ⅱ receptors in rat aortic endothelium after balloon injury.心血管疾病,2011-01.
4LAN Ping;JI Jing;HUANG Xiao-Jun;GUDURU Deepak;GROTH Thomas;VIENKEN Jorg;D1NG Hui. Adsorption/Desorption of Low-density Lipoprotein on a Heparinized Surface of Gold Sensors.化学,2012-02.
5吴长毅;曾因明;顾卫东;丁浩中;陈肖;张焰. Effect of Moderate Hypothermia on the Expression of ICAM-1 in Rat Acute Lung Injury.基础医学,2004-03.
6WANG Zuo;YANG Jian;ZHANG Xiao-lei;MA Xiao-feng;WANG Ren;ZENG Jun-fa;WEI Deng-heng;ZHANG Kai;LI Shuang;LIN Xiao-long;ZHAO Yue;JIANG Zhi-sheng. Increased Transendothelial Cells Permeability Induced by Oxidized Lipoprotein(a) Relates to Reactive Oxygen Species Generation and Desmogleins Expression.生物医学工程,2016-03.
7赖西南;王正国;朱金明;王丽丽. Effect of substance P on gene expression of transforming growth factor β-1 and its receptors in rat＇s fibroblasts.临床医学,2003-06.
8Chen-Yuan Gong;Bin Lu;Qian-Wen Hu;Li-Li Ji. Streptozotocin induced diabetic retinopathy in rat and the expression of vascular endothelial growth factor and its receptor.眼科,2013-05.
9黎崖冰;李盛青;杨文祥. Effect of Pricking Blood Therapy on Behavior and Gene Expression in a Rat Model of Migraine.中医学,2009-06.
10Yajing Wang;Jianli Zhao;Yanqing Zhang;Wayne Bond Lau;Li-Yuan Jiao;Baojiang Liu;Yuexing Yuan;Xiaoliang Wang;Ling Tao;Erhe Gao;Walter J. Koch;Xin-Liang Ma. Differential regulation of TNF receptor 1 and receptor 2 in adiponectin expression following myocardial ischemia.生理学,2013-06.

Effect of valsartan on Lectin-like oxidized-low density lipoprotein receptor-1 expression in balloon-injured rat aorta

来源期刊

相关推荐

同分类资源更多

相关关键词

Effect of valsartan on Lectin-like oxidized-low density lipoprotein receptor-1 expression in balloon-injured rat aorta

来源期刊

相关推荐

同分类资源 更多

相关关键词

同分类资源更多