摘要
Theintrinsicgrowthabilityofalltheneuronsdeclinesduringdevelopmentalthoughsomemaygrowbetterthanothers.Numerousintracellularsignalingproteinsandtranscriptionfactorshavebeenshowntoregulatetheintrinsicgrowthcapacityinmatureneurons.Amongthem,PI3kinase/Aktpathwayisimportantforcontrollingaxonelongation.Asanegativeregulatorofthispathway,thetumorsuppressorphosphataseandtensinhomolog(PTEN)appearscriticaltocontroltheregenerativeabilityofyoungandadultneurons.ThisreviewwillfocusonrecentresearchprogressinaxonregenerationandneuralrepairbyPTENinhibitionandtherapeuticpotentialofblockingthisphosphataseforneurologicaldisorders.InhibitionofPTENbydeletioninconditionalknockoutmice,knockdownbyshort-hairpinRNA,orblockadebypharmacologicalapproaches,includingadministrationofselectivePTENantagonistpeptides,stimulatesvariousdegreesofaxonregrowthinjuvenileoradultrodentswithcentralnervoussysteminjuries.Importantly,post-injuryPTENsuppressioncouldenhanceaxonalgrowthandfunctionalrecoveryinadultcentralnervoussystemafterinjury.
出版日期
2015年09月19日（中国期刊网平台首次上网日期，不代表论文的发表时间）
