摘要
Lymphomararelyoccursduringpregnancy,makingthisconditiondifficulttodefine.Lymphomasthatoccurinreproductiveorgansduringpregnancyexhibituniqueclinicalcharacteristics.Amongthelimitedcases,non-Hodgkin'slymphoma(NHL)showsaconsiderablyhigherincidenceratethanHodgkin'slymphoma(HL);NHLalsodisplaysclinicalcharacteristics,suchashighaggressiveness,advancedstage,andpooroutcome.Thisstudyreportsonfourcasesoflymphomasinnon-gonadalorgans(HL,n=2;NHL,n=2)duringpregnancy.Thetumorsrapidlyprogressedinallpatientsduringpregnancybutremittedattheendofpregnancyand/ortherapy.ThetwoHLcaseswerenodularsclerosisclassicalHLandtreatedwithchemotherapyafterterminatingthepregnancy.OneoftheNHLcaseswasprimarycutaneousfollicularcenterlymphoma,aBcell-derivedindolentlymphoma.Thepatientwasfollowedupwithoutanytherapyafterterminatingherpregnancy.Theothercasewasafollicularlymphomagrade3B,whichwastreatedwithchemotherapyafterdelivery.Wealsoconductedaliteraturereviewof165lymphomacasesoccurringduringpregnancyreportedfrom1976to2013torevealthecorrelationbetweenpregnancyandlymphomaprogression.Immunohistochemistrystudieswereperformedtodeterminetheexpressionofestrogen/progesteronereceptors(ER/PR),andERwasweaklypositiveandsporadic.Weconcludedthatlymphomasoccurringduringpregnancyshouldbemanagedwithapromptandreasonabletreatment.Highestrogenlevelinmaternalbodymayaffectlymphomaprogression.
出版日期
2016年03月13日（中国期刊网平台首次上网日期，不代表论文的发表时间）
