摘要
Objective:ToinvestigatewhethervitaminDreceptorgene(VDR)BsmI-rs1544410andFokI-rs2228570polymorphisms,smokingduration,andbodymassindex(BMI)areriskfactorsforcutaneousmelanoma,especiallymetastaticmelanoma.Methods:Westudied120cutaneousmelanomacases[68stageIandIInon-metastaticmelanoma(NMetM)patients,plus52StageIIIandIVmetastaticmelanoma(MetM)patients],and120matchinghealthycontrolsfromnortheastItaly.VDRpolymorphismsweremeasuredbyrestrictionfragmentlengthpolymorphismanalysis.AbsenceorpresenceofBsmIandFokIrestrictionsiteswasdenotedby'B'and'F'orby'b'and'f,'respectively.Results:VDR-BsmIbbgenotypewasmorefrequentamongMetM(32.7%)thanamongNMetMcases(13.2%),withoddsratio(OR)=3.18.Comparisonofallmelanomapatientsvshealthycontrolsshowedthatthefollowingbiomarkerswereatrisk:≥20yearsofsmoking(OR=2.43);≥20yearsofsmokingcombinedwithbb(OR=4.78),Bb+bb(OR=2.30),Ff(OR=3.04),andFf+ff(OR=3.08);obesity(BMI>30Conclusions:RiskfactorsforcutaneousMetMincludetwoVDRpolymorphismscombinedwithsmokingdurationandobesity.Resultssuggestgene-environmentimplicationsinmelanomasusceptibilityandseverity.Futurestudiesinlargercohortsandinsubjectswithdifferentgeneticbackgroundarewarrantedtoextendourfindings.
出版日期
2017年03月13日（中国期刊网平台首次上网日期，不代表论文的发表时间）
