摘要
AIM:Todeterminethehypothesisthatinflatingtheballoonsintheduodenalpapilladetermineschangesinthebiochemicalmarkersofpancreatitis.METHODS:Fourgroupsofpigswereused:Grouppapilla(GP),theovertube’sballoonwasinflatedintheareaofthepapilla;GP+doubleballoonenteroscopy(GP+DBE),theovertube’sballoonwaskeptinflatedintheareaofthepapillafor20minbeforeaDBE;GroupDBE(GDBE),DBEwascarriedoutafterinsuringtheballoon’sinflationfarfromthepancreaticpapilla;andGroupcontrol(GC).Serumconcentrationsofamylase,lipaseandC-reactiveprotein(CRP)wereevaluated.Pancreaseswereprocessedforhistopathologyexamination.RESULTS:Mainchangesoccurred24haftertheprocedurecomparedwithbaselinelevels.AmylaselevelsincreasedsignificantlyinGP(59.2%higher)andweremoderatelyhigheringroupsGP+DBEandGDBE(22.7%and20%,respectively).LipaseincreasedinGPandGP+DBE,whereasithardlychangedinGDBEandinGC.CRPincreasedsignificantlyinGP,GP+DBEandGDBE,whilenochangeswerereportedforGC.NostatisticallysignificantdifferencebetweengroupsGPandGP+DBEwasfoundforthehistopathologicalfindings,exceptforvacuolizationandnecrosisofthepancreaticparenchymathatwashigherinGPthaninGP+DBE.CONCLUSION:Themanipulationoftheduodenalpapillabytheinflatedovertube’sballoonduringDBEcausespancreaticstructuraldamageandincreasedbiochemicalmarkersassociatedwithpancreatitis.
出版日期
2016年12月22日（中国期刊网平台首次上网日期，不代表论文的发表时间）
