摘要
Studiesdemonstrateadeclineinandrogenswithageandthisresultsintheandropause.Theobjectiveofthispaperistoreviewtheliteratureonhormonalchangesthatoccurintheagingmalesanddetermineifthereareassociationsbetweendecreasedtestosterone,dehydroepiandrosterone(DHEA)anddecreasedcognitivefunction.Trialsofandrogenreplacementanditsimpactoncognitivefunctionwillalsobeanalyzed.MethodofanalysiswillbebyathoroughsearchofarticlesonMEDLINE,theIntemetandmajorabstractdatabases.Resultsoftheauthor'sownresearchin302menoftheassociationofmemorylossasasymptomintheandropausewillbepresented.Inaddition,theauthorsopentrialoftestosteronereplacementinhypogonadicmenwithAlzheimer'sdiseasewillalsobepresented.Theresultsoftheauthor'strialwillbecomparedwithotherinvestigators.Highendogenoustestosteronelevelpredictedbetterperformanceonvisualspatialtestsinseveralstudies,butnotinallstudies.Likewise,testosteronereplacementinhypogonadicpatientsimprovedcognitivefunctionsinsomebutnotallstudies.Testosteronehasalsobeenshowntoimprovecognitivefunctionineugonadalmen.SeveralstudieshaveshownthatdeclinesinDHEAmaycontributetoAlzheimer'sdiseaseandtheresultsofdoubleblindstudieswithDHEAreplacementanditseffectoncognitionwillalsobepresented.Insummary,thereisstillnoconsensusthatandrogenreplacementisbeneficialincognitivedeclinebutthisoptionmayprovepromisinginsomepatients.
出版日期
2001年03月13日（中国期刊网平台首次上网日期，不代表论文的发表时间）
