摘要
AbstractObjective:To identify risk factors for anastomotic leakage after gastrectomy in patients with Siewert type II/III adenocarcinoma (AEG) of the esophagogastric junction.Methods:This was a retrospective case-control study of 903 patients with Siewert type II/III AEG treated from January 2012 to January 2015 at the Shanxi Cancer Hospital in China. All patients underwent gastrectomy, and their clinical characteristics were analyzed to identify associations with anastomotic leakage. Independent risk factors were identified by binary logistic regression. The 2-year disease-free survival was calculated and compared between patients with anastomotic leakage and control patients. The study was approved by the Institutional Review Board of Shanxi Medical University (approval No. 2014-09-39) on September 19, 2014.Results:Out of the 903 patients were included in the study, 80 (8.86%, 80/903) experienced anastomotic leakage. The mortality rate attributed to anastomotic leakage was 8.75% (7/80). Logistic regression analysis revealed that preoperative hypoalbuminemia (odds ratio (OR)=3.249, 95% confidence interval (CI): 1.569-6.725, P=0.002), type of reconstruction (OR=1.795, 95% CI: 1.026-3.142, P=0.040), and combined organ resection (OR=1.807, 95% CI: 1.069-3.055, P=0.027) were independent risk factors for anastomotic leakage.Conclusion:Preoperative hypoalbuminemia, type of reconstruction, and combined organ resection were identified as risk factors for anastomotic leakage in patients undergoing gastrectomy for Siewert type II/III AEG.
机构地区
Department of Gastrointestinal Surgery, Shanxi Cancer Hospital, Shanxi Medical University, Taiyuan,Department of Gastrointestinal Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian Province,Department of Gastrointestinal Surgery, Changzhi People’s Hospital, The Affiliated Ho
出版日期
2021年08月14日（中国期刊网平台首次上网日期，不代表论文的发表时间）
