简介：Extragonadalprimaryyolksactumoroftheintestinaltractoriginisexceedinglyrare.Throughamultipledisciplinaryteam,thediagnosisandtreatmentofprimaryintestinalyolksactumorwerefurtherdefined.Wereport2suchcaseswithdetailedhistologicandimmunohistochemicalanalysis.Thetwopatientswerea7-year-oldgirlanda29-year-oldwoman.Bothofthempreoperativelyhadanelevatedserumalphafetoprotein(AFP)level(≥1,210ng/mL).Thetumorsarelocatedintheintestineandimagingexaminationindicatedtherectumastheprimarysite.Grosslythemasswasgrey-whiteandcrisptexture.Microscopicexaminationfeaturedreticular,microcystic,macrocystic,papillary,solid,andsomeglandularpatterns.Immunohistochemically,tumorcellsofbothcaseswerepositiveforSALL4,AFP,pan-cytokeratin(AE1/AE3),andglypican-3.Simultaneously,astainforEMA,OCT4,CD30,HCG,vimentinandCK20werenegativeinall2neoplasms.Thefeaturesofmorphology,immunohistochemistry,laboratoryexaminationsandimagingstudiesconsistofthediagnosisofprimaryyolksactumoroftheintestine.