简介:Parkinson’sdisease(PD)isanage-relatedneurodegenerativedisordercharacterizedbytypicalmotorsignsandsymptomsthatareduetodopamine(DA)depletioninthebasalganglia.ThetreatmentofPDissymptomatic,andaimsatreplacingthelostDAinputusingeitherL-DOPAorDAagonists.ThecausesofPDareunknownin
简介:Alzheimer’sdisease(AD)isoneofthemostdevastatingdiseasesaffectingthelifeandhealthofagingpopulation.TwohallmarksofADaresenileplaquesandneurofibrillarytangles,andADiswellknownforthemassivelossofneuronsandimpairedcognitivefunctionsespeciallymemoryloss.Despiteextensivesearchforeffectivetreatment,available
简介:Despitetheadvancesincombinatorialorsyntheticchemistryandbioinformatics,recentliteraturehasdemonstratedtherelevanceofnatureandbiomassasasourceofnewmoleculestotreatdifferentpathologies,i.e.,bioactivecompoundsobtainedfromEcteinascidiaturbinatetotreatsometypesofcancerorrapamycinfromStreptomyceshygroscopicustopreventorganrejectionaftertransplant.Thistrend
简介:CurrentevidenceshowsthatapolipoproteinE(APOE),apolipoproteinCI(APOC1)andlowdensitylipoproteinreceptor-relatedprotein(LRP)variationsarerelatedtolate-onsetAlzheimer’sdisease.However,itremainsunclearifgeneticpolymorphismsinthesegenesareassociatedwithcognitivedeclineinlate-onsetAlzheimer’sdiseasepatients.Weperformeda30-monthlongitudinalcohortstudytoinvestigatetherelationshipbetweenAlzheimer’sdiseaseandAPOE,APOC1,andLRP.Inthisstudy,78ChineseHanpatientswithlate-onsetAlzheimer’sdiseasewererecruitedformGuangxiZhuangAutonomousRegioninChina.APOE,APOC1,andLRPgenotypingwasperformedusingpolymerasechainreaction-restrictionfragmentlengthpolymorphisms.TheMini-MentalStateExaminationandClinicalDementiaRatingScalewereusedtoassesspatients’cognitivefunction.Aftera30-monthfollow-upperiod,wefoundasignificantreductioninMini-MentalStateExaminationtotalscore,ahigherproportionofpatientsfulfillingcognitiveimpairmentprogressioncriteria,andahigherproportionofAPOC1H2carriersinAPOEε4carrierscomparedwithnon-carriers.Inaddition,theAPOEε4allelefrequencywassignificantlyhigherinthecognitiveimpairmentprogressiongroupcomparedwiththenon-cognitiveimpairmentprogressiongroup.Inconclusion,APOEε4playsanimportantroleinaugmentingcognitivedecline,andAPOC1H2mayactsynergisticallywithAPOEε4inincreasingtheriskofcognitivedeclineinChinesepatientswithlate-onsetAlzheimer’sdisease.