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  • 简介:AIMDevelopmentaltoxicitytestingtocurrentinternationalguidelinesinvolvesexposureofpregnantanimals,mostlyratsandrabbits,andsubsequentassessmentoftoxiceffectsintheirfetuses.Alternativemethodshavebeendevelopedsince1980s.Themostcomplexassaysinthisareamakedistinctiveandextensiveuseofisolatedpostimplantationrodentembryoswhichareculturedinvitroduringthephaseofmajororganogenesis.Theobjectiveofthisstudyistoestablishaninvitroembryotoxicitytest----basedonpostimplatation9.5dwholeembryoculture(WEC)and3T3celltoxicity.Thepossibilitiesfortheirapplicationasembryotoxicityscreenshavebeeninvestigated.

  • 标签: 中国 青年研究员 座谈会 药理学 应用软件 胚胎毒性