简介：Thepermeationbehaviorofmicrocapsulesormembraneshasbeenstudiedex-tensivelyforitsimportanceindesigningandconstructingsustaineddrugreleasede-vicesandartificialcells.Particularly,biomedicalmembraneiswidelyusedanddevel-opedoTherehavebeennumerousstudiesonthepermeabilityoflowmolecularweightsolutesthroughmembranes.Thestimulussensitivemembraneshavenotbeenfullyexploredyet.Thispaperwasmainlyconcernedwithspecialfunctionmembranespre-

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简介：Sixnovelbenzoylphenylureachitininhibitorderivativesweresynthesizedintheyieldsof30%-50%fromthereadilyavailablestartingmaterialchlorothalonil1viasequentialfluorineexchange,aminolysis,hydrolysisandacylationreactions.

简介：Inthispaper,theselectiveadsorptionofLDLonchitosanmodifiedwithPEGandAsp.wasstudied.TheadsorptionrateofLDLandHDLonthedoublemodifiedchitosanwas57%and12%respoectively,TheresultsshownthatthedoublemodifiedchitosancanbeusedaadsorbentforselectivebindingtoLDL,thisworkmayhelptodevelopfunctionalcolumnsforhemoperfusion.

简介：ＴＨＥＳＴＵＤＩＥＳＯＮＤＥＧＲＡＤＡＴＩＶＥＫＩＮＥＴＩＣＯＦＭＥＤＩＣＡＬＣＨＩＴＯＳＡＮＴＨＥＳＴＵＤＩＥＳＯＮＤＥＧＲＡＤＡＴＩＶＥＫＩＮＥＴＩＣＯＦＭＥＤＩＣＡＬＣＨＩＴＯＳＡＮＳｕｎＤｕｏｘｉａｎ；ＤｏｎｇＡｎｊｉｅ（Ｄｅｐａｒｔｍｅｎｔ...

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简介：极其细小的chitosan粒子被由水，三重氢核X-100，octanol和环己烷组成的反向的微乳液准备。粒子被采用并且比较了使用TEM和红外的准备极其细小的chitosan的二个方法，和为极其细小的chitosan粒子的形成的可能的机制被建议。试验性的结果证明联合了离子的冻结和cross-linking的方法与92nm的一条平均直径给了一致地大小的chitosannanoparticles，当没有离子的冻结的cross-linking与188nm的943nm和宽度的平均长度生产了细长纤弱的chitosan粒子时。

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简介：Hybridbraidsofpolyglycolide(PGA)andchitosanwerepreparedbythethree-yarnbraidingmethodfromPGAandchitosanfiberbundles.Thesebraidswereinvitrodegradedbyincubatingtheminphosphatebufferedsaline(PBS)atpH7.4and37℃for5weeks.ResultssuggestedthatPGA/chitosanhybridbraidsdegradedsignificantly.ScanningelectronmicrographsshowedthatchitosanfibersinthePGA/chitosanhybridbraidwithabout750%PGAinweight(PGA75/chitosan)wereshapedintogel-likeafter5weeks,butthoseinthehybridbraidwithabout250%PGAinweight(PGA25/chitosan)didnotchange.After5weeks,theultimatetensileloadsofPGAandPGA75/chitosanbraidslostalmostcompletely,butthoseofchitosanandPGA25/chitosanbraidsremainedaround14N.ThePGA/chitosanhybridbraidswithhigherinitialultimatetensileloadwouldhavepotentialapplicationsintendon/ligamenttissuereconstruction.

简介：TheinteractionsbetweenmetalionssuchasZn2+,Pb2+,Mn2+,Hg2+,Cd2+,Ni2+andchitosanhavebeeninvestigatedusingthemodelclustermodelmethodanddensityfunctionalmethod.FulloptimizationandfrequencyanalysisofallclustermodelshavebeenperformedemployingB3LYPhybridmethodat3-21Gbasissetlevelexceptmetalionswhichwereinvokedtouseeffectivecorepotential(ECP)method.Theenergychanges,andthemainstructuralparametershavebeenobtainedduringthetheoreticalstudyoftheadsorptionofmetalionsonthechitosan.Thecalculationsshowedthatthecoordinationmodesofmetalionswithchitosanmodelsweredifferent,thegeometriesofMn2+,Zn2+,Cd2+,Hg2+,Pb2+ionscoordinatedwithtwonitrogenatomsandtwooxygenatomsweredistortedtetrahedral,whilethesquareplanarstructureofNi2+coordinatedtwonitrogenatomsandtwooxygenatomswasobserved.Theheatofreactionbetweensixmetalionsandchitosanmodelsshowedtheorder:Mn2+＞Ni2+＞Zn2+＞Pb2+＞Hg2+＞Cd2+,thissuggestedthatthecoordinationstrengthofMn2+＞Ni2+＞Zn2+＞Pb2+＞Hg2+＞Cd2+.

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简介：Thepresentinvestigationdescribesanovelmethodforpreparingsphericalchitosanparticlesbasedoncrosslinkingwithepichlorohydrin.Certainamountofpre-crosslinkingagentwasaddedtoformchitosangelsbytraditionalinversephasesuspensionpolymerization.Thenthegelswerecrosslinkedbyepichlorohydrinatbasicconditiontoobtainchitosanbeads.Theeffectsofreactionconditions,suchascrosslinkingtime,theamountofcrosslinkingagentandtheNaOttconcentration,onthephysicalpropertiesofthechitosanbeadswereinvestigated.Thebeadswerefoundtohavemoreaminogroupsinthepolymerchainsthanthebeadscrosslinkedbyglutaraldehyde.Thecapacityforcopperionsisashighas40mg/g.Thebeadshavegoodmechanicalstrengthandcanbereused.

简介：Anewandaninexpensiveadsorbentofchitosancoatedsilicaforimmobilizedmetalaffinitychromatography(IMAC)wasstudied.Afteradoublecoating,thechitosancoatedonsilicabeadscouldbeupto53.4mg/gsilicabeads.WhenpH>3.8,themetalligandCu^2+waschelatedonthecoatedchitosanwithaboundcapacityof14.6mg/gchitosanwithoutintroducingiminodiaceticacid(IDA).

简介：Thisstudyisconcernedwithchitosan-polyacrylicacidcomplexasacarriertoimmobilizeglucoseoxidase(GOD)andcellulase.TheoptimumemperatureoftheimmobilizedGOD(IG)wasdeterminedtobe60℃whichishigherthanthatofthenativeGODabout40℃.Theoptimumtemperatureoftheimmobilizedcellulase(IC)wasdeterminedtobeabout30℃higherthanthatofnativecellulase.BothoftheoptimumpHofIGandICshiftedonepHunittoacid.ImmobilizedenzymemaybeusedinmorewidepHrange.Theirstoragelifearemuchlongercomparedwiththeirnativestates.Bothofthemcanbereusedatleast12times.

简介：Objective:Toseeknewmethodforthetreatmentofperipheralnerveinjury.Methods:Inratmodelwithsciaticnervedefect,chitosan-collagenfilmwassuturedintoconduittobridge5mm,10mmnervedefects.Ratsthatunderwentend-to-endanastomosisweretakenascontrols.Generalobservation,electrophysiologicalstudy,histologicalstudyandimageanalysiswereperformedat4,8,12weekspostoperatively.Results:In5mmnervedefects,thequalityofnerveregenerationwassimilartothatofthecontrolgroup.For10mmnervedefect,nerveregenerationwasinferiortothatofthecontrolgroup.Chitosan-collagenfilmobviouslydegradedat12weekspostoperatively.Conclusions:Chitosan-collagenfilmconduitcanbeusedtobridgeperipheralnervedefect.

简介：基本上在在vitro和细胞外的矩阵种相关房间上面做的织物工程。织物工程的一个主要目标到preparate多孔为房间的三尺寸脚手架增殖，移居，differention并且形成理想的织物和机关的结构。在这研究，各种各样的内容的效果和到chitosan的木钉的macromolecular重量被调查并且评估。chitosan的毛孔形态学被改变集中控制，PEG.Chitosan多孔的支架的macromolecular重量有interconecting孔。毛孔形态学能与改变木钉集中和macromolecular重量被控制。毛孔尺寸在之间1050嗯，在水里胀大的度是85.70%。