简介:摘要目的探讨幼年系统性红斑狼疮(JSLE)神经系统表现的临床特征。方法选择本院风湿科1999年1月至2007年1月JSLE患者47例的临床资料作回顾性分析,分析其神经系统表现的临床特征。结果神经精神症候群29例(61.7%)癫痫发作17例(36.2%),狼疮性头痛7例(149%),情绪失调5例(10.6%),脑血管病4例(8.5%),急性精神错乱3例(6.4%),无菌性脑膜炎3例(6.4%),精神障碍3例(6.4%),运动障碍3例(6.4%),格林-巴利综合征2例(4.3%),颅神经病变1例(2.1%)。系统性红斑狼疮疾病活动指数(SLEDAL)和系统性红斑狼疮损伤指数(SLICC)与无神经表现的JSLE患者相比,有显著性差异。结论幼年系统性红斑狼疮病人的神经精神症候群普遍高发。
简介:AIM:Toexaminethemechanismofthedevelopmentofpseudoexfoliation(PSX)syndromeviabothcytokineformationandendothelialvasorelaxingandgrowthfactorsthatwillprovideusnewtherapeuticinsightsforthetreatment.METHODS:Thisisacrosssectionalstudyincludedtwogroups;Group1:controlpatientswithnuclearcataract(n=20,aged51-80years).Group2:PSXpatientswithnuclearcataract(n=18,aged50-90years).Patientswithotherophthalmicproblemsandsystemicdiseaseswereexcluded.Vascularendothelialgrowthfactor(VEGF),interleukin-6(IL-6)andinterleukin-1β(IL-1β)andnitrotyrosinelevelsweredeterminedthroughserumsamplesbyEnzyme-linkedimmunosorbentassay(ELISA)method.Nitrite-nitratelevelsweremeasuredwithphotometricendpointdetermination.RESULTS:Therewerenosignificantdifferencesbetweenthegroupsintermsofage,VEGF,IL-1β,nitrite-nitrateandnitrotyrosine.ThesignificantresultswerethemeanIL-6levelsthatwerehigherinPSXgroup2(37.68±29.52pg/mL)comparedtothatincontrolgroup1(15.32±10.08pg/mL)(P<0.001).CONCLUSION:SeveralinteractingandextendingbiochemicalpathwaysmayleadtothepromotionofVEGFandIL-6expressions.IL-6whichistheonlyalteredmarkerinourstudymayindirectlycauseanincreaseofvascularpermeabilityandneovascularization.WesuggestinflammationasafactorthatcanbeinvolvedinetiopathogenesisofPSX.