简介：ＲＥＳＩＤＵＡＬＳＴＲＡＩＮＩＮＣＡＮＩＮＥＡＲＴＥＲＩＥＳＭｉｎＨｕａｎｇ；ＨａｉｃｈａｏＨａｎ（ＤｅｐａｒｔｍｅｎｔｏｆＥｎｇｉｎｅｅｒｉｎｇＭｅｃｈａｎｉｃｓ，．Ｘｉ＇ａｎＪｉａｏｔｏｎｇＵｎｉｖｅｒｓｉｔｙ，Ｘｉ＇ａｎ７１００４９Ｃｈｉｎａ）...

简介：Beforethe1950s,D-transpositionofthegreatarterieswasassociatedwithnearly90%mortalitywithinthefirstyearoflife.TheMustardandSenningproceduresresultedinasignificantincreaseinthelifespanofthesepatientsbutwithnotablelong-termcomplications,includingarrhythmias,sinusnodedysfunction,chronotropicincompetence,andrightventricularsystolicdysfunction.Thearterialswitchoperation(firstdescribedbyAdibJatene)initiallyresultedinnearlyuniversaldeath.However,theuseofcoronarybuttonsforcoronaryarterytranslocationhasimprovedoperativesurvivaldramatically.Itisnowconsideredthetreatmentofchoiceinpatientsamendabletothearterialswitchoperation.Consideredananatomicrepair,resultinginconcordantventriculoarterialconnectionsandasystemicleftventricle,thearterialswitchoperationreducestheincidenceofventriculardysfunction.However,itisalsoassociatedwithlong-termcomplications,includingaorticrootdilatation,aorticvalveregurgitation,rightventricularoutflowtractobstructions,coronaryarterystenosis/compression,andbranchpulmonaryarterystenosis.

简介：Introduction,Anomalouscoronaryarteriesarefoundin0.1%–1.3%ofpatientsundergoingcoronaryangiography.AnomalouscoronaryarteriesareararebutimportantcauseofCP,arrhythmia,MI&suddencardiacdeath;andaretreatable.Angiographicevaluationcanbechallenging;misdiagnosiscanoccurinupto50%ofcases.Sometimestheseanomaliesaremissedbecauseoftheinexperienceoftheoperator.AnomalousCoronaryArteriescanbeassociatedwithcongenitalheartdiseaseorcanbeanisolatedanomaly.

简介：Pulsatilebloodflowsincurvedatheroscleroticarteriesarestudiedbycom-putersimulations.Computationsarecarriedoutwithvariousvaluesofphysiologicalparameterstoexaminetheeffectsofflowparametersonthedisturbedflowpatternsdownstreamofacurvedarterywithastenosisattheinnerwall.Thenumericalre-suitsindicateastrongdependenceofflowpatternonthebloodviscosityandinletflowrate,whiletheinfluenceoftheinletflowprofiletotheflowpattemindownstreamisnegligible.

简介：Ultrasoundsimulationforcarotidarteriesishelpfultotheperformanceassessmentsofvesselwalldetectionandsignalprocessingmethodsbyusingultrasoundtechniques.Anultrasoundsimulationmethodofcarotidarterywallwithathree-membranestructureisproposedinpresentstudy.Accordingtotheultrasoundspeckledistributionsvaryingwiththeshapesanddensitiesofscattererdistributions,aswellasthestatisticresultsoftheclinicalimages,theparametersofdistributions,densitiesandintensitiesofscatterersfordifferentkindsoftissuesinthecarotidarteryphantomsaredetermined.EachregionisacousticallycharacterizedusingFIELDIIsoftwaretoproducetheradiofrequencyechosignals,fromwhichultrasoundimagesarederived.Theresultsbasedon30simulationsshowthattheechodistributionsoftheintimae,mediae,adventitiasandbloodareconsistentwiththeclinicalones.Moreover,comparedwiththeresultsfromthecentralfrequencyof8MHz,themeanmeasurementsforthicknessesoftheintima,mediaandadventitiamembranes,aswellasthelumendiameterfromthesimulationimagesbasedon12MHzarethesameasthepresetones,andthemaximumrelativeerrorsarethe4.01%,1.25%,0.04%and0.15%,respectively.Thesimulationunderthisconditionismorerealistic.

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简介：Cardiovasculardisease(CVD)istheleadingcauseofdeathandamajorhealthcarechallengeglobally.Coronaryarterydisease(CAD)isaprimaryunderlyingpathologicalprocessinthemajorityofcardiovasculardiseasecases.Magneticresonanceimaging(MRI)canplayapotentiallyimportantroleinthemanagementofCADasanoninvasiveimagingmodalitywithoutionizingradiation,althoughitsearlypromisehasnotbeendeliveredbecauseofseveralcrucialtechnicallimitations.However,recentinnovationsinMRIhavereopenedthedoor,withtremendousopportunitiesformultiparametricassessmentofCADincludingluminalstenosis,plaqueburdenandcomposition,anddiseaseactivitiessuchasinflammationandhemorrhage.NovelMRIacquisitionandreconstructionstrategiesnowoffermuchincreasedspatialresolutionandimagequalityandshortenedexaminationtimescomparedwithconventionalapproaches.RecentclinicalexperiencesofcoronaryMRIindicatedthepotentialtoimprovethecurrentmanagementofcoronaryatherosclerosis,suchasidentifyingthepatientsatthehighestriskandevaluatingtherapeuticresponses.InthisreviewwediscussthelatesttechnicaladvancesandclinicalinsightsincoronaryMRI.

简介：Objective:Toobserveeffectsofarginineonarterialendotheliuminjuredbyischemia-reperfusion(IR),andexploreitspossiblemechanism.Methods:Fifty-fourratsweredividedinto3groupsandtreatedinrespectiveways:(1)drinkingtapwaterasthecontrol;(2)drinkingtapwatercontaining2.5%L-arginine;(3)drinkingtapwatercontaining2.5L-argininetogetherwithintraperitonealinjectionofN^G-nitro-L-argininemethylester5mg·kg^-1·d^-1.asegmentofthecommoncarotidarterywasoccludedfor1h,andthenreperfused.Samplestakenatdifferentpost-IRtimefromthesegmentwerepreparedfortheultrastructuralandCeH2O2cytochemicalobservation.Thenakedindex(NI)ofinternalelasticlamina(IEL)wasmeasuredforcomparingtheendothelialinjureextentanditsrepairprocess.Results:Lessdamageofendothelialcells(EC),moreplateletsadheringtonakedIELandmoreregeneratingECwereobservedinGroup2.TheNIvaluesofsamplestakenat1,2,3daftertheIRwererespectively0.92±0.08,0.88±0.03and0.41±0.02inGroup1,andreducedto0.52±0.05,0.19±0.08and0.06±0.01inGroup2(P<0.05-0.01).InGroup3,theendotheliumdamagewasnotalleviated,andsoweretheNI.TheCe-H2O2particlesdepositedonthelumensurfaceofendotheliumweremuchlessinGroup2thaninGroups1and3.Conclusions:L-argininepromotestherepairprocessofIR-injuredendotheliumprobablythroughtheremovalofoxygenfreeradicalsbyNO.

简介：Insufficientbloodsupplyofcerebralarteriesisacommonlyseenandfrequentlyoccurreddiseaseamongthemiddle-agedandsenilepeople.Inrecentyears,theauthorofthispapertreated68casesofinsufficientbloodsupplyofcerebralarteriesbyacupuncturewithsatisfactoryresults.Itisreportedasfollows.

简介：AbstractBackground:Diabetes mellitus (DM) is considered a cardiovascular risk factor. The aim of this study was to analyze the prevalence and volume of coronary artery plaque in patients with diabetes mellitus (DM) vs. those without DM.Methods:This study recruited consecutive patients who underwent coronary computed tomography (CT) angiography (CCTA) between October 2016 and November 2017. Personal information including conventional cardiovascular risk factors was collected. Plaque phenotypes were automatically calculated for volume of different component. The volume of different plaque was compared between DM patients and those without DM.Results:Among 6381 patients, 931 (14.59%) were diagnosed with DM. The prevalence of plaque in DM subjects was higher compared with nondiabetic group significantly (48.34% vs. 33.01%, χ2 = 81.84, P < 0.001). DM was a significant risk factor for the prevalence of plaque in a multivariate model (odds ratio [OR] = 1.465, 95% CI: 1.258-1.706, P < 0.001). The volume of total plaque and any plaque subtypes in the DM subjects was greater than those in nondiabetic patients significantly (P < 0.001).Conclusion:The coronary artery atherosclerotic plaques were significantly higher in diabetic patients than those in non-diabetic patients.

简介：雄激素缺乏强烈与可勃起的机能障碍(编辑)被联系。不适当的阴茎动脉的血流动是到阴茎海绵体的血流动主要是的编辑的原因从内部pudendal动脉(国际语音学协会)导出的专业之一；然而，没有学习在国际语音学协会功能上评估了雄激素剥夺的效果。我们假设了那阉割损害国际语音学协会反应和结构，在我们的学习贡献编辑，Wistar雄的老鼠，8-week-old，被阉割并且在orchiectomy以后学习了30天。老鼠国际语音学协会的功能、结构的性质是坚定的分别地使用电线和压力肌动描记器系统。蛋白质表示被西方的污点和immunohistochemistry决定。血浆睾丸激素层次用IMMULITE1000免疫分析系统被决定。展出的阉割的老鼠损害了可勃起的功能，由减少的intracavernosal压力/平均数代表了动脉的压力比率。从阉割的老鼠的国际语音学协会展出了减少的phenylephrine-，电场刺激(EFS)导致了收缩并且减少导致醋胆素、导致EFS的vasodilatation。从阉割的老鼠的国际语音学协会展出了减少的内部直径，外部直径，动脉的墙的厚度，和代表性的区域。阉割减少了nNOS和肌动朊表示和增加的骨胶原表示，p38(Thr180/Tyr182)phosphorylation，以及caspase3劈开。在结论，雄激素缺乏与国际语音学协会反应和结构的缺陷被联系并且增加了表明标记的apoptosis。我们的调查结果建议导致缺乏的脉管的机能障碍是的那雄激素包含hypotrophic的一个事件国际语音学协会的脉管的改变。

简介：ＲＥＰＬＡＣＥＭＥＮＴＯＦＡＲＴＥＲＩＥＳＷＩＴＨｅＰＴＦＥＶＡＳＣＵＬＡＲＧＲＡＦＴＳＬＩＮＥＤＷＩＴＨＣＯＮＦＬＵＥＮＴＡＵＴＯＬＯＧＯＵＳＥＮＤＯＴＨＥＬＩＡＬＣＥＬＬＳＩＮＮＯＮ－ＨＵＭＡＮＰＲＩＭＡＴＥＳＲＥＰＬＡＣＥＭＥＮＴＯＦＡＲＴＥＲ...

简介：AbstractBackground:The aim of this study was to retrospectively analyze our experience with the patients who underwent surgical treatment of posterior communicating artery (PComA) aneurysms originating from fetal posterior cerebral artery (fPCA) and analyze the risk factors for the postoperative radiological infarction and outcome.Methods:From 2011 to 2020, we retrospectively reviewed 74 PComA aneurysms originating from fPCA in terms of the clinical and radiological features and obtained the follow-up data from the Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University. The relationships between these features and follow-up data were assessed with the univariate and multivariate analysis.Results:In this series, 74 aneurysms were occurring at the origin of fPCAs. All the patients showed complete obliteration of their aneurysms. Full fPCA type tends to be a predictive factor for radiological infarction (univariate χ2 = 5.873, P = 0.027; multivariate OR = 0.264, P = 0.060). Postoperative radiological infarction (univariate χ2 = 12.611, P = 0.001; multivariate OR = 6.033, P = 0.043), rupture (univariate χ2 = 4.514, P = 0.047; multivariate OR = 57.966, P = 0.044), and hypertension (univariate χ2 = 5.301, P = 0.024; multivariate OR = 24.462, P = 0.029) tend to be the independent predictive factors for poor prognosis at 3 months after discharge.Conclusions:In conclusion, we report a series of patients harboring aneurysms originating from the fPCA. Surgical clipping is a reliable strategy. Full fPCA type is related to postsurgical infarction. Postoperative radiological infarction, rupture, and hypertension tend to be the independent predictive factor for poor prognosis at 3 months after discharge.

简介：‘Stent对stent’研究是被设计与以前同意的相比显示出新stent图案的优势的一种使随机化的试用。这些研究被规章的机构通常使用，例如美国食物药品管理局(食物及药品管理局)，到表示同意到新stent图案。有这些临床的试用的问题是他们的高费用和困难。在这份报纸，为‘stent对stent’的一种数字选择复杂临床的研究被介绍。一个有限元素模型被开发在冠的stent放置以后在结果上调查stent设计的影响。二商业地可得到的stents(NIR和多连接stents)被建模，他们的行为以压力分发在推广期间被比较，光线的获得，外部直径变化并且节略。而且，狭窄率上的stent设计的效果被在动脉以内比较压力分发调查。在stented动脉的动脉的墙压力的分析显示多连接stent设计原因与slotted试管NIR设计相比与局部性的stenotic损害降低应力到一个动脉粥样硬化患者容器。有观察临床的狭窄的调查结果相互关联与多连接stent设计相比在NIR评估狭窄率，它更高报导了。

简介：纸由使用biomagnetic液体动力学(BFD)的原则通过一个多孔的中等题目处理biomagnetic液体流动的一个基本问题的理论调查到一个磁场。学习与液体的磁化与温度变化的一种状况相关。液体被认为非牛顿，其流动被一个二年级的方程管理粘弹性的液体。隧道的墙被假定可拉长，在表面速度与从坐标的起源的纵的距离成正比的地方。这个问题首先被归结为解决包含七个参数的联合非线性的微分方程的一个系统。把血看作biomagnetic液体并且使用现在的分析，被尝试由开发一个合适的数字方法并且由设计一个适当有限差别计划计算血流动的一些参数。计算结果在图形的形式被介绍，并且从而，一些理论预言在一个磁场的行动下面处于一个过高热的状态关于血的hemodynamical流动被做。结果清楚地显示磁性的偶极子的存在忍受潜力以便在电磁的过高热的治疗学的过程期间在动脉影响血流动的特征到重要程度。学习将吸引临床医生，结果将在由电磁的过高热的方法的癌症病人的治疗是谁有用的注意。

简介：1-(2,6-Dimethylphenoxy)-2-(3,4-dimethoxyphenylethylamino)-propanehydrochloride(DDPH)isanovelantihypertensiveagentbasedonstructuralcharacteristicsofmexiletineandverapamine.WeinvestigatedtheeffectofDDPHonvasodilatationandneuroprotectioninaratmodelofcerebralischemiainvivo,andarabbitmodelofisolatedbasilararteriesinvitro.OurresultsshowthatDDPH(10mg/kg)significantlyincreasedhippocampalbloodflowinvivoincerebralischemicrats,andexerteddose-dependentrelaxationofisolatedbasilararteriescontractedbyhistamineorKClintheinvitrorabbitmodel.DDPH(3×10–5M)alsoinhibitedhistamine-stimulatedextracellularcalciuminfluxandintracellularcalciumrelease.OurfindingssuggestthatDDPHhasavasodilativeeffectbothinvivoandinvitro,whichmediatesaneuroprotectiveeffectonischemicnervetissue.