简介：在这篇文章，作者在在作者说的美国保存健康改革在疾病预防的角色上评论说健康提升和疾病预防编程序，这经常是常识，低技术、直接，但是成功地实现他们在这个国家的护理系统仍然是的许多陷井主要在治疗疾病而非避免他们上组织了。

简介：TherelationshipbetweenembBmutationofMycobacteriumtuberculosisandethambutol(EMB)resistanceoftheclinicalisolatesoftuberculouspatientsinChinawasinvestigatedbyreversedotblothybridization(RDBH)inadditiontoevaluatingtheclinicalvaluewithapplicationofPCR-RDBHtechniquetodetectEMBresistance.Inthepresentstudy,thegenotypesofthe258bpfragmentsofembBgenesfrom196clinicalisolatesofM.tuberculosiswereanalysedwithRDBHandDNAsequencing.Itwasdemonstratedthat60outof91phenotypicallyEMB-resistantisolates(65.9%)showed5typesofmissensemutationsatcodon306ofembBgene,resultinginthereplacementoftheMetresidueofthewildtypestrainwithVal,IleorLeuresidues.Inthesemutations,theGTPmutation(38/91,41.8%)andtheATAmutation(16/91,17.6%)werethemostencounteredgenotypes.TheembBmutationatcodon306couldalsobefoundin69isolatesofphenotypicallyEMB-sensitivebutresistanttootheranti-tuberculousdrugs,butnosuchgenemutationcouldbefoundin36strainsofdrug-sensitiveisolates.Meanwhile,theconcordancewiththeresultsofDNAsequencingforonewide-typeprobeand5probesforspecificmutationswas100%.ItwasconcludedthattheEMB-resistanceoccurringinmostM.tuberculosisisduetoappearanceofembBmutationatcodon306,andthePCR-RDBHassaywasprovedtobearapid,simpleandreliablemethodforthedetectionofgenemutations,whichmightbeagoodalternativeforthedrug-resistancescreening.