简介：AbstractType 2 diabetes mellitus and metabolic disorders have become an epidemic globally. However, the pathogenesis remains largely unclear and the prevention and treatment are still limited. In addition to environmental factors during adulthood, early life is the critical developmental window with high tissue plasticity, which might be modified by external environmental cues. Substantial evidence has demonstrated the vital role of early-life nutrition in programming the metabolic disorders in later life. In this review, we aim to overview the concepts of fetal programming and investigate the effects of early-life nutrition on energy metabolism in later life and the potential epigenetic mechanism. The related studies published on PubMed database up to March 2020 were included. The results showed that both maternal overnutrition and undernutrition increased the riskes of metabolic disorders in offspring and epigenetic modifications, including DNA methylation, miRNAs, and histone modification, might be the vital mediators. The beneficial effects of early-life lifestyle modifications as well as dietary and nutritional interventions on these deleterious metabolic remolding were initially observed. Overall, characterizing the early-life malnutrition that reshapes metabolic disease trajectories may yield novel targets for early prevention and intervention and provide a new point of view to the energy metabolism.

简介：InthelaterpartoftheTang,localinterestsgroupswhoserepresentativeswereprovincialgovernorszealouslysupportedcarvingFangshanStoneSutrasandotherBuddhistaffairs.CommandingofficersofsubordinatecountiesinLulongprovincechargedadministrative,militaryandsupervisingaffairs,andhadrelativeorfake-relativelinkswiththeirprovincialgovernorsorbodyguards.Themilitarypowerofsubordinatecountiesalsoplayedanimportantroleinthetransformationofpoliticalconditions.CommandingofficersofsubordinatecountiesoftentookpartincarvingFangshanStoneSutras,too.TheyalsocarvedStoneSutraswithbodyguardsfortheirprovincialgovernors.ThiswasasignificantwayofcondensingYouzhoubloc.

简介：睡眠与健康工作和学习的关系甚为密切。良好的睡眠，可调节生理机能，维持神经系统的平衡，是生命中的重要一环。缺乏睡眠对中学生的学习、生活会有一定的消极影响，所以学生应当合理地安排自己的睡眠时间。

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简介：五年前，来自加勒比海的5级飓风“卡特琳娜（Katrina）”在美国登陆。路易斯安那州首府新奥尔良市顷刻间排水系统陷入瘫痪，残砖断瓦，居民流离失所；五年后的新奥尔良市会有什么变化？重建的会是百娃心中的理想之城吗？

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简介：【口语专练】选择恰当的句子补全对话，有两项多余。A：Hi,Tony!WheredidyougolastSunday？B：WewenttotheSummerPalace.A：（1）（）B：Wesawsomeinterestingplaces.A：（2）（）B.Yes,wedid.Allofuswereveryhappy.A：（3）（）

简介：当父母亲决定要搬到另一个地方时，我曾认为这是多么悲哀的一件事，因为在这里有我的朋友，还有我的男朋友。不过．经过一年的时间，我却发现生活中的这些变化给我带来了很多……

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简介：美国前总统比尔·克林顿花了两年时间写成的自传——《我的生活》，于2004年6月22日在全美上市销售，引起了不小的轰动，当天就售出40万册。这本书记述了克林顿一生的方方面面。被称为是有史以来最详尽细致的美国总统传记。下面就让我们来欣赏该书第一章的部分摘录。

简介：未来的生活是什么样子？每个人阅历的不同，生活环境的不同，就会有不同的憧憬。那么科学家们会怎么说——

简介：在走廊上疾走，拐进教室．就看见Sheep倚着墙角，露出邪邪的笑和一口整齐的牙齿。我每天都来得很早，只是Sheep总是比我更早。

简介：我们都知道电话是贝尔发明的，除了电话，贝尔还发明了电子探测器、真空衣、听度计等许多东西，贝尔对世界的进步做出了卓越的贡献。真可谓生命不息，发明不止。

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简介：Threecareerwomenplayingmultipleroles:daughter,wife,mother,colleagueandfriend,handleeverydaypressureandenjoylifetothefull.Suddenlyoneday,theirliveschange.Theybecomepatients,identifiedwiththeirmedicalcasehistoryratherthanbusinesscard.Facingdeath,thesethreewomenpooltheircourage,wisdomandtenacity.