简介：Inthepresentstudy,aseriesofnovelnitricoxide-hydrogensulfidereleasingderivativesof(S)-3-n-butylphthalide((S)-NBP)weredesigned,synthesized,andevaluatedaspotentialantiplateletagents.CompoundNOSH-NBP-5displayedthestrongestactivityininhibitingthearachidonicacid(AA)-andadenosinediphosphate(ADP)-inducedplateletaggregationinvitro,with3.8-and7.0-foldmoreeffectivenessthan(S)-NBP,respectively.Furthermore,NOSH-NBP-5couldreleasemoderatelevelsofNOandH2S,whichwouldbebeneficialinimprovingcardiovascularandcerebralcirculation.Moreover,NOSH-NBP-5couldrelease(S)-NBPwhenincubatedwithratbrainhomogenate.Inconclusion,thesefindingsmayprovidenewinsightsintothedevelopmentofnovelantiplateletagentsforthetreatmentofthrombosis-relatedischemicstroke.

简介：目的马尾藻类海草wightiiGreville是属于有大约200种类的Sargassaceae家庭的海洋的棕色的水藻。整个干燥植物粉末的ethanolic摘录包含了众多的phytoconstituents，包括flavonoids。学习在老鼠集中于马尾藻类海草wightii的anticancer活动。在二剂量的马尾藻类海草wightii(EESW)的ethanolic摘录铺平的方法被用来用DAL房间线在老鼠检验anticancer活动导致癌症。身体重量，可行、不能生存的肿瘤房间计数，吝啬的幸存时间，寿命的增加，和hematological参数为EESW的anticancer活动被观察。在老鼠的DAL房间的intraperitoneal接种显著地增加了的结果癌症房间计数。在在对待EESW的组癌症动物观察的癌症细胞数字的减少显示测试药在肿瘤细胞增长上有重要禁止的效果。有EESW的治疗也在肿瘤重量显示出重要减少，并且因此增加了对待DAL的老鼠的lifespan。另外，EESW管理显著地在对待DAL的老鼠恢复了hematological参数。现在的学习结果建议摘录提议的那个政府的结论提高了抗氧化剂潜力。因此，EESW拥有anticancer活动，这能从这研究被结束。

简介：Inthepresentstudy,theeffectsofPleurotusnebrodensispolysaccharide(PN-S)ontheimmunefunctionsofimmunosuppressedmiceweredetermined.Theimmunosuppressedmousemodelwasestablishedbytreatingthemicewithcyclophosphamide(40mg/kg/2d,CY)throughintraperitonealinjection.TheresultsshowedthatPN-SadministrationsignificantlyreversedtheCY-inducedweightloss,increasedthethymicandsplenicindices,andpromotedproliferationofTlymphocyte,Blymphocyte,andmacrophages.PN-SalsoenhancedtheactivityofnaturalkillercellsandincreasedtheimmunoglobulinM(IgM)andimmunoglobulinG(IgG)levelsintheserum.Inaddition,PN-Streatmentsignificantlyincreasedthephagocyticactivityofmouseperitonealmacrophages.PN-Salsoincreasedthelevelsofinterleukin-6(IL-6),tumornecrosisfactor-α(TNF-α),interferon-γ(INF-γ),andnitricoxide(NOS)insplenocytes.qRT-PCRresultsalsoindicatedthatPN-SincreasedthemRNAexpressionofIL-6,TNF-α,INF-γ,andnitricoxidesynthase(iNOS)inthesplenocytes.TheseresultssuggestthatPN-Streatmentenhancestheimmunefunctionofimmunosuppressedmice.Thisstudymayprovideabasisfortheapplicationofthisfungusinadjacentimmunopotentiatingtherapyagainstcancerandinthetreatmentofchemotherapy-inducedimmunosuppression.

简介：Ginkgoditerpenelactonesmeglumineinjection(GDLI)isacommerciallyavailableproductusedforneuroprotection.However,thepharmacokineticpropertiesoftheprototypesandhydrolyzedcarboxylicformsoftheprimarycomponentsinGDLI,i.e.,ginkgolideA(GA),ginkgolideB(GB),andginkgolideK(GK),haveneverbeenfullyevaluatedinbeagledogs.Inthiswork,asimple,sensitive,andreliablemethodbasedonultra-fastliquidchromatography-tandemmassspectrometry(UFLC-MS/MS)wasdeveloped,andtheprototypesandtotalamountsofGA,GB,andGKweredeterminedinbeagledogplasma.Theplasmaconcentrationsofthehydrolyzedcarboxylicformswerecalculatedbysubtractingtheprototypeconcentrationsfromthetotallactoneconcentrations.Forthefirsttime,thepharmacokineticsofGA,GB,andGKwerefullyassessedinthreeforms,i.e.,theprototypes,thehydrolyzedcarboxylicforms,andthetotalamounts,afterintravenousadministrationofGDLIinbeagledogs.Itwasshownthatginkgolidesprimarilyexistedinthehydrolyzedforminplasma,andtheratioofhydrolysatestoprototypeformsofGAandGBdecreasedgraduallytoahomeostaticratio.AllofthethreeformsofthethreeginkgolidesshowedlinearexposureofAUCtothedosages.GA,GB,andGKshowedaconstanthalf-lifeapproximately2.7,3.4,and1.2h,respectively,whichwereconsistentfortheformsatthreedoselevels(0.3,1.0,and3.0mg·kg~(-1))andafteraconsecutiveinjectionofGDLIfor7days(1.0mg·kg~(-1)).

简介：Cancerisamajorhealthconcernandleadingburdenoneconomyworldwide.Anincreasingeffortisdevotedtoisolationanddevelopmentofplant-deriveddietarycomponentsaseffectivechemo-preventiveproducts.Phytochemicalcompoundsfromnaturalresourcessuchasfruitsandvegetablesareresponsiblefordecreasingtheriskofcertaincancersamongtheconsumingpopulations.Apigenin,aflavonoidphytochemicalfoundinmanykindsoffruitsandvegetables,hasbeenshowntoexertsignificantbiologicaleffects,suchasanti-oxidant,anti-inflammatoryandmostparticularlyanti-neoplasticproperties.Thisreviewisintendedtosummarizethemostrecentadvancesintheanti-proliferativeandchemo-preventiveeffectsofapigeninindifferentcancermodels.Analysisofthedatafromthestudiedcancermodelshasrevealedthatapigeninexertsitsanti-proliferativeeffectsthroughmultipleandcomplexpathways.Thisguidedustodiscoversomecontroversialresultsabouttheexactroleofcertainmolecularpathwayssuchasautophagyintheanticancereffectsofapigenin.Further,therewerecumulativepositiveevidencessupportingtheinvolvementofcertainpathwayssuchasapoptosis,ROSandDNAdamageandrepair.Apigeninpossessesahighpotentialtobeusedasachemosensitizingagentthroughtheup-regulationofDR5pathway.Accordingtothesepreclinicalfindingswerecommendthatfurtherrobustunbiasedstudiesshouldconsiderthepossibleinteractionsbetweendifferentmolecularpathways.

简介：AIM:ToevaluatetheeffectofOcimumsanctumleafextractonthedietarysupplementationinthetransgenicDrosophilamodelofParkinson’sdisease.METHOD:TheeffectofOcimumsanctumleafextractwasstudiedonthetransgenicDrosophilamodeloffliesexpressingnormalhumanalphasynuclein(h-αs)intheneurons.O.sanctumextractatfinalconcentrationsof0.0428×10-4,0.87×10-4,and1.85×10-4g·mL-1ofdietwereestablishedandtheflieswereallowedtofeedfor21days.Theclimbingassayandlipidperoxidationweretakenasparametersforthestudy.RESULTS:ThesupplementationofO.sanctumextractshowedadose-dependentsignificantdelayinthelossofclimbingabilityandreductioninoxidativestressinthebrainofPDmodelflies.CONCLUSION:TheresultsofthepresentstudyshowedthattheO.sanctumextractispotentinreducingthePDsymptomsintransgenicDrosophilamodel.

简介：目的：探索炙甘草汤对哇巴因所致心肌细胞触发活动的影响及作用机理。方法：应用微电极技术及单相动作电位技术观察炙甘草汤对哇巴因所致触发性离体及在体心肌触发活动的影响，并运用Na^＋，K^＋-ATP酶活性测定试剂盒测定心肌细胞的Na^＋，K^＋-ATP酶活性。结果：（1）哇巴因（0．5×10^-6mmol·mL^-1）高钙台氏液灌流可引起豚鼠离体左心室乳头肌触发活动，炙甘草汤（3、6、12mg·ml^-1）明显降低触发活动的幅度、时程和发生率，高浓度时完全抑制触发活动的发生.（2）哇巴因（4×100mmol·kg^-1，iv）可引起豚鼠在体心肌触发活动.炙甘草汤（10、20、30g生药／kg，ig）明显延迟触发活动的发生，降低触发活动的幅度和发生率，并提高触发性心肌细胞Na^＋，K^＋-ATP酶活性．结论：炙甘草汤抑制哇巴因所致触发活动的发生可能是通过提高Na^＋，K^＋-ATP酶活性而实现的。

简介：’99上半年全国中药交流会、“大连·中国中医药暨保健品展览会”于1999年6月22-25日在大连举行。原国家中医药管理局副局长张洪魁、国家经贸委医药司吕志坤处长、中国药材公司总经理范洪哲和副总经理秦祖辉与天津、上海、广州、四川、大连等药材公司领导、大连市政府负责人到会。大

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简介：一年一度的樟树药交会于10月18日召开。今年樟树会的特点是:会场内大冷,交易少,会场外小热,冬令补品交易颇多;远地客商少,各大药材市场来的个体药商大幅减少,江西本省来的客商略多,附近诊所、医院来的人反而增多。往年10月16日、17日樟树药交会就能见到高潮。今年16日会场内展馆基本未开门,17日虽然大多数展馆开门,但谈生意的寥若辰星,展馆里很少有人光顾,也无人来租用。摆摊用的竹床还有一大堆等着人来租。有个小药厂讲,租摊花了五百

简介：AnovelPleurotusnebrodensispolysaccharide(PN-S)waspurifiedandcharacterized,anditsimmune-stimulatingactivitywasevaluatedinRAW264.7macrophages.PN-SinducedtheproliferationofRAW264.7cellsinadose-dependentmanner,asdeterminedbytheMTTassay.AfterexposuretoPN-S,thephagocytosisofthemacrophageswassignificantlyimproved,withremarkablechangesinmorphologybeingobserved.FlowcytometricanalysisdemonstratedthatPN-SpromotedRAW264.7cellstoprogressthroughSandG2/Mphases.PN-Streatmentenhancedtheproductionsofinterleukin-6(IL-6),nitricoxide(NO),interferongamma(INF-γ),andtumornecrosisfactor-α(TNF-α)inthemacrophages,withup-regulationofmRNAexpressionsofinterleukin-6(IL-6),induciblenitricoxidesynthase(iNOS),interferongamma(INF-γ)andtumornecrosisfactor-α(TNF-α)beingobservedinadose-dependentmanner,asmeasuredbyqRT-PCR.Inconclusion,theseresultssuggestthatthepurifiedPN-Scanimproveimmunitybyactivatingmacrophages.

简介：目的：研究山茱萸环烯醚萜总苷（ICO）对高糖或糖化终产物（AGEs）培养肾小球系膜细胞（GMC）增殖和Na^＋．K^＋-ATP酶活性的影响。方法：用含AGEs或高糖的培养液配制ICO、氨基胍，同时设对照。GMC培养48h后MTT法考察GMC的增殖情况，试剂盒测试细胞悬液中细胞蛋白含量，再进行Na^＋，K^＋-ATP酶测定。结果：于葡萄糖或AGEs中GMC的吸收度值增大，Na^＋，K^＋-ATP酶活性显著降低，而加入ICO后，则表现为对抗高糖或AGEs对GMC的增殖作用，并能提高Na^＋，K^＋-ATP酶活性。结论：ICO能抑制高糖或AGEs对GMC的过度增殖，修复高糖或AGEs致GMC的Na^＋，K^＋-ATP酶活性降低。

简介：日前，以“产学研联合，促进药用植物资源开发”为主题的第九届全国药用植物和植物药学术研讨会在海口隆重召开。会上，36位专家、学者分别从中药材生产保护性发展、药用植物种质鉴别、海南药用植物资源研究与开发等方面在会上作专题发言，他们发表的学术观点和创新的思维，让与会代表收获颇丰。

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