简介：ObjectiveTostudytheroleofdiureticagentsintreatingsuddendeafness(SD)andexplorethepossibilityofendolymphatichydropsasapotentialcauseofSD.MethodsTwenty-eightSDcaseswerereviewed.In23cases,treatmentwasinitiatedwithroutineagents.Diureticagentswerelateraddedin8ofthesecasesthatfailedtorespondtoroutinetreatmentagents.Diureticagentswereincludedintheinitialtreatmentintherest5cases.Intotal,13casesreceiveddiureticsinadditiontoroutinetreatmentagentsand15casesreceivedconventionaltreatmentonly.ResultsInthe8caseswhoreceiveddiureticsafterfailedconventionaltreatments,4showedhearingimprovement,whereasall5casesinwhichdiureticswereincludedintheinitialtreatmentdemonstratedhearingimprovement.ConclusionTheseresultssuggestapossibleroleofendolymphatichydropsinthepathophysiologiccourseofSD.Diureticsshouldbeconsideredwhenclearindicationsexistwithnoconflictstoothermedicalconditions.

简介：

简介：这篇论文在指导网络调查控制动态代理人的全球行为。代理人是Lyapunov马厩，在一根线被散布，并且通过一个指导网络交流。网络的通讯拓扑学被一张指导的图描绘，控制协议在简单线性分散的反馈法律被设计。我们学习代理人将分别地在下面完成聚集，和批评、分叉的轨道的不同条件。我们在网络下面的动态代理人系统上的调查被扩大到时间延期网络案例。而且，我们与二学习案例在系统的预先指定的虚拟领导人。数字模拟被给并且证明我们的理论结果是有效的。

简介：Alaboratoryinvestigationonreactionbetweenchelatingagentsandchromiumwasconductedtoevaluatetheeffectofchelatingagentsontheadsorptionanddesorptionofchromiuminsediment.Theamountofadsorbedchromium(VI)insedimentdecreasedslightlyby5%-10%becauseofadditionofchelatingagents.ChelatingagentsinhibitedtheremovalofCr(Ⅲ)bysedimentfromsolutionsandtheinhibitingeffectwasintheorder:citricacid>tartaricacid>EDTA,Salicylicacid.Noeffectofchelatingagentsondesorptionofchromiuminsedimentwasobserved.

简介：AbstractEpigenetic regulation includes changes of DNA methylation and modifications of histone proteins and is essential for normal physiologic functions, especially for controlling gene expression. Epigenetic dysregulation plays a key role in disease pathogenesis and progression of some malignancies, including acute myeloid leukemia (AML). Epigenetic therapies, including hypomethylating agents (HMAs) and histone deacetylase (HDAC) inhibitors, were developed to reprogram the epigenetic abnormalities in AML. However, the molecular mechanisms and therapeutic effects of the two agents alone or their combination remain unknown. An overview of these epigenetic therapies is given here. A literature search was conducted through PubMed database, looking for important biological or clinical studies related to the epigenetic regimens in the treatment of AML until October 15th, 2019. Various types of articles, including original research and reviews, were assessed, identified, and eventually summarized as a collection of data pertaining the mechanisms and clinical effects of HMAs and HDAC inhibitors in AML patients. We provided here an overview of the current understanding of the mechanisms and clinical therapeutic effects involved in the treatment with HMAs and HDAC inhibitors alone, the combination of epigenetic therapies with intensive chemotherapy, and the combination of both types of epigenetic therapies. Relevant clinical trials were also discussed. Generally speaking, the large number of studies and their varied outcomes demonstrate that effects of epigenetic therapies are heterogeneous, and that HMAs combination regimens probably contribute to significant response rates. However, more research is needed to explore therapeutic effects of HDAC inhibitors and various combinations of HMAs and HDAC inhibitors.

简介：Nanotechnologyprovidesvariousnanomaterialswithtremendousfunctionalitiesforcancerdiagnosticsandtherapeutics.Recently,theranosticshasbeendevelopedasanalternativestrategyforefficientcancertreatmentthroughcombinationofimagingdiagnosisandtherapeuticinterventionsundertheguidanceofdiagnosticresults.Ultrasound(US)imagingshowsuniqueadvantageswithexcellentfeaturesofreal-timeimaging,lowcost,highsafetyandportability,makingUScontrastagents(UCAs)anidealplatformforconstructionofcancertheranosticagents.ThisreviewfocusesonthedevelopmentofnanomaterialsincorporatedmultifunctionalUCAsservingastheranosticagentsforcancerdiagnosticsandtherapeutics,viaconjugationofsuperparamagneticironoxidenanoparticles(SPIOs),CuSnanoparticles,DNA,siRNA,goldnanoparticles(GNPs),goldnanorods(GNRs),goldnanoshell(GNS),grapheneoxides(GOs),polypyrrole(PPy)nanocapsules,Prussianblue(PB)nanoparticlesandsoontodifferenttypesofUCAs.Thecancertreatmentcouldbemoreeffectivelyandaccuratelycarriedoutundertheguidanceandmonitoringwiththehelpoftheachievedtheranosticagents.Furthermore,nanomaterialsincorporatedtheranosticagentsbasedonUCAscanbedesignedandconstructedbydemandforpersonalizedandaccuratetreatmentofcancer,demonstratingtheirgreatpotentialtoaddressthechallengesofcancerheterogeneityandadaptation,whichcanprovidealternativestrategiesforcancerdiagnosisandtherapeutics.

简介：

简介：

简介：

简介：有通讯噪音的分离时间的一阶的多代理人网络在考虑下面。基于吵闹的观察，一致控制为网络被给与修理并且变化时间的拓扑学。在结果的代理人的状态靠近环的网络被随机的近似(SA)更新算法，和为网络的一致分析转弯是为SA的集中分析。为有固定拓扑学的网络，如果与网络联系的图被连接，建议一致控制与概率一导致代理人的一致。在变化时间的拓扑学的情况中，如果图联合在一个确定的时间时期被连接，类似的结果被导出。与存在结果相比，这里考虑的网络在在更弱的假设下面的一个更一般的背景，强壮的一致被一个更简单的证明建立。

简介：这篇论文以一种分布式的方式考虑多代理人系统的形成控制问题。在多重代理人之中宣传拓扑学的信息的二个盒子，由图形模型描绘了，被考虑。一个人是固定拓扑学。其它正在交换代表有限、不太可靠的信息交换的拓扑学。在这篇论文建立的本地形成控制策略基于存在一致控制策略的简单修正。而且，一些存在集中条件被显示甚至在连续时间的一致盒子中是我们的模型的一种特殊情况。因此，这篇论文的结果关于一致问题扩大存在结果。

简介：AbstractThe novel coronavirus disease 2019 (COVID-19) is the third coronavirus outbreak in the last two decades. Emerging and re-emerging infections like COVID-19 pose serious challenges of the paucity of information and lack of specific cure or vaccines. This leaves utilisation of existing scientific data on related viral infections and repurposing relevant aetiologic and supportive therapies as the best control approach while novel strategies are developed and trialled. Many promising antiviral agents including lopinavir, ritonavir, remdesivir, umifenovir, darunavir, and oseltamivir have been repurposed and are currently trialled for the care for COVID-19 patients. Adjunct therapies for the management of symptoms and to provide support especially in severe and critically ill patients have also been identified. This review provides an appraisal of the current evidence for the rational use of frontline therapeutics in the management of COVID-19. It also includes updates regarding COVID-19 immunotherapy and vaccine development.

简介：Inordertostudytheeffectofanti-HABsagentsonPenaeuschinensis,thetoxicityexperimentsonclay,Ca(ClO)2,FeCl3,andAlCl3toPenaeuschinensisarecarriedout.Theresultsshowthat:(1)theclayisn'ttoxictoPenaeuschinensis;(2)Ca(ClO)2hasnotoxicitytoPenaeuschinensisatlowlevels,buthasacuteandchronictoxicityathighlevels;(3)PenaeuschinensiscanaccumulateFeandAl.Thetoxiceffectneedsfurtherstudy.

简介：多保护是在安全管理的一个原则，并且反爆炸的使用和耐火的代理人是它的关键部分。在这份报纸，反爆炸的领域里的nano氧化物粒子的性质并且耐火被分析。纳米粒子的沉积速度是计算的。CH4作为一个例子被拿，并且它起始的阶段的燃烧机制被结束。反应系统的分子的精力上的15氧化物的效果与程序Hyperchem6被计算，并且在激进分子和氧化物之间的可能的接触方式被得到。氧化物例如ZrO2，能与激进分子结合，这被结束，并且因此阻止燃烧反应。nano-ZrO2暴发地产生了喷雾器，这被发现比在用作反爆炸和耐火的代理人的另外的对应物优异，因此，将在安全管理起一个日益重要的作用。

简介：Erectiledysfunction(ED)isahighlyprevalentdisorderaffectinganestimated152millionmenworldwideandisassociatedwithavarietyofbehavioralriskfactors,suchascigarettesmokingandexcessivealcoholconsumption,aswellasnumerousage-relatedmedicalconditions,notablytype-2diabetesmellitusandcardiovasculardisease.Arationalstep-wiseapproachwhichincludescomprehensivemedicalandsexualhistory,afocusedphysicalexaminationandessentiallaboratorytestssuchasfastingglucose,lipidprofileandtestosteroneassayistobepreferred.Currentdiagnosticwork-updoesnotrecommendanyofthespecializedtestswhichwerepreviouslyconsideredmandatory-i.e.penilepharmacotesting,Duplexultrasoundandnocturnalpeniletumescence.HormonalreplacementtherapyisappropriateonlyinthehypogonadalmalewithED.Priortodirectintervention,thephysicianshouldconsideralteringmodifiableriskfactorsorcauses,althoughfrequentlyinsufficienttoreverseEDcompletely.Whenindicated,oraltherapywithnewmolecules(phosphodiesteraseinhibitorsorapomorphine)isthefirst-linetreatmentforthemajorityofpatientsbecauseofpotentialbenefitsandlackofinvasiveness.

简介：

简介：在过去的年，histonedeacetylases(HDAC)的overexpression导致的肿瘤suppressor基因的epigenetic沉默在carcinogenesis起一个重要作用，这被发现了。因此，HDAC禁止者作为附件出现了自从他们能堵住特定的HDAC的活动，为多重人的癌症的治疗学的代理人恢复一些肿瘤suppressor基因的表示并且导致房间区别，生长拘捕和apoptosis。迄今为止，HDAC禁止者由导致房间死亡的精确机制充分还没被阐明了，单个HDAC禁止者的角色没被识别。而且，在癌症治疗的HDAC禁止者的实际使用，以及他们有另外的治疗学的策略的synergistic效果还有待于被评估。在这篇评论文章，我们简短在反癌症HDAC禁止者和他们的潜在的临床的值的开发的研究讨论最近的进展。

简介：这篇论文问一个新问题：我们怎么能控制集体行为组织ofself的多代理人系统？我们试着由建议新观点called'SoftControl'回答这个问题，它把存在代理人的本地规则放在系统。我们由案例研究显示出软控制的可行性。考虑简单却典型的分布式的multi-agentmodel由Vicsek等求婚了。为鸟结队：每个代理人以一样的速度，但是与基于它的自己的标题的一般水准用一条本地规则被更新的不同标题和它的邻居的标题移动。这个模型的大多数研究关于self-organizedcollective行为，例如标题的同步。我们想要由软控制在这个组的集体行为(标题)干涉。一个指定方法是增加一个特殊代理人，叫了一个“党羽”，它能被我们控制，但是被另外的代理人当作一个平常的代理人。我们为党羽构造一条控制法律以便它能同步整个组到一个客观标题。这条控制法律被证明是有效经分解并且数字地。注意软控制与分布式的控制的途径不同。在分布式的系统干涉是一个自然方法。它可以在复杂系统的控制上拿出许多有趣的问题和挑战。

简介：Pyrimidinederivativeshavebeenreportedasneuroprotectiveagentsusefulforthetreatmentofvariousneurodegenerativedisorders.Inthepresentstudy,severalpyrimidineanalogueshavebeenevaluatedasneuroprotectiveagentsinMorriswatermazemodel.Itwasobservedthatpyrimidinederivatives8–17considerablyimprovelearning,memory,andmovementdeficitsinanimalmodels.Biochemicalestimationsofbrainserumoftreatedanimalsrevealedsuppressionofoxidativeandnitrosativestress,acetylcholinesteraseactivity,andotherparameterswhichleadstoneurodegenerationofbrain.Ofallthepyrimidinederivatives,thiomorpholinederivative8andpiperazineethanolderivative17werefoundtobethemostactiveneuroprotectiveagentsandproducedeffectscomparabletostandarddrugrivastigmineintermsofbehavioral,biochemical,andmolecularaspects.

简介：MicroRNAs(miRNAs)areasetofnon-codingsmallRNAmoleculesthatplayacriticalroleinregulationofproteincodinggenesincells.MiRNAshavebeenextensivelystudiedasnovelbiomarkers,therapeutictargets,andnewdrugsinvarioushumandiseases.Breastcancerisaoneoftheleadingtumortypessignificantlyaffectingwomenhealthworldwide.Overthepastdecade,anumberofnaturalagents,suchaspaclitaxelandcurcumin,havebeenappliedfortreatmentandpreventionofbreastcancerduetotheirrelativelylowtoxicity.However,themechanismsofactionhavenotbeencompletelyunderstood.InvestigationonmiRNAsisabletopotentiallyprovideanovelinsightintobetterunderstandingtheanticanceractivitiesofthesenaturalproducts.GiventhatasinglemiRNAcantargetmultiplegenes,theoretically,thosegenesinvolvedinacertainphenotypecanbeclusteredwithoneorafewmiRNAs.Therefore,pleiotropicactivitiesofnaturalagentsshouldbeinterpretedbyinteractionsbetweenselectedmiRNAsandtheirtargets.Inthisreview,wesummarizethelatestpublicationsrelatedtothealterationsofmiRNAsbytwonaturalagents(paclitaxelandcurcumin)thatarecurrentlyusedininterventionofbreastcancer,andconcludethatthemechanisminvolvingtheregulationofmiRNAexpressionisoneofthekeystounderstandpleiotropicactivitiesofnaturalagents.