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简介：Anticancerimmunotherapyhasundergonealongevolvingjourneyfordecades,andhasbeendramaticallyappliedtomainstreamtreatmentsinoncologyinrecent5years.Thisprogressrepresentsanadvancedmilestonefollowingcytotoxicmedicineandtargetedtherapy.Cellularimmunityplaysapivotalroleintheimmuneresponsesofhoststotumorantigens.Suchimmunityisnotablysuppressedduringneoplasticprogressionduetoimmuno-editingprocesses.Cellularimmunitycanalsobeselectivelyreactivatedtocombatmalignancieswhileexploitingtheadvantagesofcontemporaryscientificbreakthroughsinmolecularimmunologyandgeneticengineering.Therapidadvancementofcellularimmunity-basedtherapeuticapproacheshasachievedhighefficacyincertaincancerpatients.Consequently,thelandscapeofoncologicmedicineandpharmaceuticalinnovationhastransformedrecently.Inthisregard,wepresentacomprehensiveupdateonclinicallyestablishedanti-cancertreatmentswithcellimmunityaugmentationasthemajormechanismofaction.

简介：Inthestudyathand,theimageofanelementaryschoolteacherinpublicshallbeanalyzedindetail：his/herreputation,characteristics,andtrustinhim/her.Especiallytheimageofelementaryschoolteachersshallbeconsidered.Thisinvestigationdealswiththequestion＂Whymenmainlyteachatsecondaryschools＂.Areasonforthiscouldthebadimageandtheappreciationtowardselementaryschoolteachersinsociety.Tocounterthesetendencies,measureshavebeentaken,likeBoy＇sDays,tomaketheelementaryschoolmoreattractiveformen,tooWiththehelpofpolarityprofilesanddistancescales,theimagesofmaleandfemaleelementaryschoolteachersarecompared.Theresultsshowthattheimageofelementaryschoolteachersisoverallpositivelyrated,butmenworkingatelementaryschoolsareimputedtoshowalternativebehaviorandfemalecharacteristics.Furtherresearchandimplicationforactingarenecessarytofindoutwhatrelationshipsexistbetweentheimageandthechoiceofprofessionofelementaryschoolteacherstotakeeffectivemainstreammeasures.

简介：TheU.S.mainstreammedia'sreportsoftheOccupyWallStreetcampaignclearlyshowthatthereisno'freepresswithoutlimits'inanycountry.TheyrevealtheU.S.mediatendstodealwithinternalandexternalfactsindifferentways,andfrequentlymaintainsdoublestandards.

简介：Beingavisually-impaired(VI)studentattendingmainstreamclassesposesachallengetothemconsideringthelimitationpresentedbytheirlimitedvision.Thisphenomenologicalstudytriedtoexplorethesedifficultiesandidentifythedifferentcopingskillsthathelpedtheminpursuingtheirschooling.ItwasfoundoutthatVIstudentsdevelopedacertainadaptivemechanismthatenablesthemtosurvivetheiracademicjourney.Theirdifficultytaughtthemtoinnovatethemselvestobecomeaccustomedtothegrowingdemandofsocietyforthemtobeequallycompetitiveandproductiveindividualthatdoesnotconsidertheirdifficultiesashindrance.ItwasfoundoutthatVIstudentswhoareinthemainstreamclasseshaveastrongersocio-academicadaptabilitywhichenablesthemtorelatethemselvestotheirmainstreamcounterpartsandtoexcelintheiracademics.Thestudyrevealedthattheirsocialadaptationinvolvesstrongspiritualfoundation,self-confidence,self-motivation,senseofbelongingness,andbettersupportsystemfromfamiliesandfriends.Ontheotherhand,theiracademicadaptationincludestechnology,effectiveteacheraides,innovativestrategies,andmaterialsfortheblind.Whenallthiscomponentsareconsidered,thereisanassurancethatVIstudentsattendingmainstreamclassescanfinishtheirschooling.

简介：Background:Childrenspend70%oftheschooldaysittinginclass.Classroom-basedactivebreakscanbenefitchildren’sphysicalhealth,butifthebreaksarecognitivelydemanding(i.e.,combinephysicalexertionandmentalengagement),theymayalsoimprovefocusandcognitivefunctions.Teachersandstudentsplayacrucialroleinthesuccessfulimplementationofactivebreaks,andtheirperspectivesarecriticaltothefeasibilityofthesestrategies.Theaimofthisstudywastoassessthefeasibilityofimplementingacognitivelychallengingmotortaskasanactivebreakinmainstreamandspecialprimaryschools.Methods:Atotalof5teachersin2mainstreamschoolsand7teachersin1specialschool(attendedbychildrenwithneurodevelopmentaldisorders)attendeda20-mintrainingonhowtoimplementa4-mincognitivelychallengingactivebreak,beforeconductingafeasibilitytrial(twiceadayfor1week).Tounderstandindividualperceptions,one-on-onesemistructuredinterviewswereconductedbeforeandafterthetrialwithteachers,andfocusgroupinterviewswereconductedwithtypicallydevelopingchildrenafterthetrial.Questionswerebasedonapredefinedframeworkforfeasibilitystudies.Allinterviewswereaudiorecorded,transcribedandanalyzedinNVivo11usingaframeworkapproach.Atotalof12teachers(11females;7between20and34yearsold)and34children(16girls;9.3±1.7years,mean±SD)participatedintheinterviews.Results:Inmainstreamschools,teachersviewedthecognitivelychallengingmotortaskasappropriateandpotentiallybeneficialforchildren’shealthandfocus.Childrenreportedenjoyingtheactivebreaks.Teachersinspecialschoolsviewedthetaskascomplexandpotentiallyfrustratingforchildren.Inbothschooltypes,children’sdisruptivebehaviorandlackoftimewereseenasthemainpotentialbarrierstoimplementation.Theuseofmusic,videos,visualcards,andsupportstaffwerenotedaspotentialfacilitators.Conclusion:Thecognitivelychallen

简介：MainstreamlineissignificantfortheYellowRiversituationforecastingandfloodcontrol.Aneffectivestatisticalfeatureextractionmethodisproposedinthispaper.Inthismethod,abetween-classscatteringmatrixbasedprojectionalgorithmisperformedtomaximizebetween-classdifferences,obtainingeffectivecomponentforclassification;thenhigh-orderstatisticsareutilizedasthefeaturestodescribethemainstreamlineintheprincipalcomponentobtained.Experimentsareperformedtoverifytheapplicabilityofthealgorithm.TheresultsbothonsynthesizedandrealscenesindicatethatthisapproachcouldextractthemainstreamlineoftheYellowRiverautomatically,andhasahighprecisioninmainstreamlinedetection.

简介：Althoughmanyliteratureshavebeenfocusedontheunderneathflowandlossmechanism,veryfewexperimentsandsimulationshavebeendoneundertheengines'representativeworkingconditionsorconsideringtherealcavitystructureasawhole.Thispaperaimsatrealizingthegoalofdesignofefficientturbineandscrutinizingthevelocitydistributioninthevicinityoftherimseal.Withtheaidofnumericalmethod,anumericalmodeldescribingtheflowpatternbothinthepurgeflowspotandwithinthemainstreamflowpathisestablished,fluidmigrationanditsaccompaniedflowmechanismwithintherealisticcavitystructure(withrimsealstructureandconsideringmainstream&secondaryairflow'sinteraction)isusedtoevaluateboththeflowpatternandtheunderneathflowmechanismwithintheinwardrotatingcavity.Meanwhile,theunderneathflowandlossmechanismarealsostudiedinthecurrentpaper.Thecomputationalresultsshowthatthesealingairflow'singestionandejectionarehighlyinterwoundwitheachotherinbothupstreamanddownstreamflowoftherimseal.Boththedownstreamblades'potentialeffectsaswellastheupstreamblades'waketrajectorycanbringabouttheingestionofthehotgasflowwithinthecavity,abruptincreaseofthestaticpressureisbelievedtobethemainreason.Also,theresultsindicatethatsealingairflowejectedthroughtherearcavitywillcauseunexpectedlossneartheoutletsectionofthebladesinthedownstreamoftheHProtorpassages.