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简介：Naturalproductshavegainedpopularityworldwideforpromotinghealthcare,aswellasdiseaseprevention.Alkaloidsareimportantchemicalcompoundsthatserveasarichreservoirfordrugdiscovery.Severalalkaloidsisolatedfromnaturalherbsexhibitantiproliferation,antibacterial,antiviral,insecticidal,andantimetastaticeffectsonvarioustypesofcancersbothinvitroandinvivo.Thispaperfocusesonthenaturally-derivedalkaloidssuchasberberine,matrine,piperine,fritillarine,andrhynchophylline,etc.,andsummarizestheactionmechanismsofthesecompounds.Basedontheinformationintheliteraturethatissummarizedinthispaper,theuseofalkaloidsasdrugsisverypromising,butmoreresearchandclinicaltrialsarenecessarybeforefinalrecommendationsonspecificalkaloidscanbemade.Followingthis,itishopedthatasaresultofthisreview,therewillbeagreaterawarenessoftheexcellentpromisethatnaturalalkaloidsshowforuseinthetherapyofdiseases.

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简介：Cloudmicrophysicalpropertyretrievalsfromtheactivemicrowaveinstrumentonasatelliterequiretheclouddropletsizedistributionobtainedfromaircraftobservationsasaprioridataintheiterationprocedure.Thecloudlognormalsizedistributionsderivedfrom12flightsoverBeijing,China,in2008–09werecharacterizedtoevaluateandimproveregionalCloudSatcloudwatercontentretrievals.Wepresentthedistributionparametersofstratiformclouddroplet(diameter<500μmand<1500μm)anddiscusstheeffectoflargeparticlesondistributionparameterfitting.Basedonthreeretrievalschemeswithdifferentlognormalsizedistributionparameters,theverticaldistributionofcloudliquidandicewatercontentwerederivedandthencomparedwiththeaircraftobservations.Theresultsshowedthattheliquidwatercontent(LWC)retrievalsfromlargeparticlesizedistributionsweremoreconsistentwiththeverticaldistributionofcloudwatercontentprofilesderivedfrominsitudataon25September2006.WethenappliedtwoschemeswithdifferentaprioridataderivedfromflightdatatoCloudSatoverpassesinnorthernChinaduringApril–Octoberin2008and2009.TheCloudSatcloudwaterpath(CWP)retrievalswerecomparedwithModerateResolutionImagingSpectroradiometer(MODIS)liquidwaterpath(LWP)data.TheresultsindicatedthatconsideringaprioridataincludinglargeparticlesizeinformationcansignificantlyimprovetheconsistencybetweentheCloudSatCWPandMODISCWP.Theseresultsstronglysuggestthatitisnecessarytoconsiderparticleswithdiametersgreaterthan50μminCloudSatLWCretrievals.

简介：FragileXsyndromeisthemostcommonformofinheritedmentalretardationaffectingupto1in4000individuals.ThesyndromeisinducedbyamutationintheFMR1gene,causingadeficiencyinitsgeneby-productFMRP.ImpairmentinthenormalfunctioningofFMRPleadstolearningandmemorydeficitsandheightenedsensitivitytosensorystimuli,includingsound(hyperacusis).ThemolecularbasisoffragileXsyndromeisthoroughlyunderstood;however,theneuralmechanismsunderlyinghyperacusishavenotyetbeendetermined.Astheinferiorcolliculus(IC)istheprincipalmidbrainnucleusoftheauditorypathway,thecurrentstudyaddressesthequestionsunderlyingtheneuralmechanismofhyperacusiswithintheICoffragileXmice.AcuteexperimentswereperformedinwhichelectrophysiologicalrecordingsoftheICinFMR1-KOandWTmiceweremeasured.ResultsshowedthatQ-valuesforWTweresignificantlylargerthanthatofFMR-1KOmice,indicatingthatWTmiceexhibitsharpertuningcurvesthanFMR1-KOmice.WealsofoundtheratioofthemonotonicneuronsintheKOmicewasmuchhigherthantheWTmice.TheseresultssuggestthatlackofFMRPintheauditorysystemaffectsthedevelopmentalmaturationandfunctionofstructureswithintheauditorypathway,andinthiscasespecificallytheIC.ThedysfunctionobservedwithintheauditoryneuralpathwayandinparticulartheICmayberelatedtotheincreasedsusceptibilitytosoundasseeninindividualswithfragileXsyndrome.OurstudymayhelponunderstandingthemechanismsofthefragileXsyndromeandhyperacusis.

简介：Inthepresentwork,themicrostructure,texture,andmechanicalpropertiesofacold-rolledTi-IFsteel,afterannealingatdifferentheatingrates,havebeeninvestigated.Theresultsrevealthatthemeangrainsizeisgraduallyrefinedfrom19.2to16.3μmastheheatingrateincreasesfrom4to50℃/s,butrefinedonlyslightlyatheatingratesofover50℃/s.Therecrystallizationmicrostructurehasastrongtexture,whichisaresultofthesharpeningofthefavorable{111}//ND(normaldirection)texturecomponentsorγ-fiber.Withincreasingheatingrates,thepeakvalueoff(g)ofγ-fiberdecreasesfrom17to9.Theyieldandtensilestrengthsincreasegraduallyastheheatingrateincreasesfrom4to50℃/s,butremainalmostunchangedatheatingratesofmorethan50℃/s.Thetotalelongationanduniformelongationincreasegraduallyastheheatingrateincreasesfrom4to100℃/s,butdecreasesslowlyforheatingrateshigherthan100℃/s.Astheheatingrateincreasesfrom4to100℃/s,theplasticstrainratioofthesteeldecreasesfrom2.8to2.2;however,itincreasesto2.9forheatingratesabove100℃/s.Thestrainhardeningexponentremainsunchangedat0.27inallannealingcycles.

简介：Themechanismsfortheregulationofsynapticdopamine(DA)includeitsreleasefrompresynapticvesicles,itsinteractionwithpost-synapticandpre-synapticDAreceptors,thereuptakeofDA,viadopaminetransporter(DAT),thediffusionofDAanditsmetabolismbymono-amineoxidase(MAO)andcatechol-O-methyltransferase(COMT).DAcontrolscomplexand

简介：Acompetitiveenzyme-linkedimmunosorbentassay(ELISA)wasdevelopedtodetermineruscogenin(RUS)byusingthemonoclonalantibody(McAb).ThemonoclonalantibodyagainstRUS,secretedfromtheestablishedhybridomacelllines,wasidentifiedasbeingoftheIgG1isotype.TheMcAbexhibitedhighspecificitytoRUS,showingaveryslightcrossreactivitywithdiosgenin(15.7%),andnocross-reactivitytosarsasapogenin,diammoniumglycyrrhizinate,oleanolicacidandnotoginsenosideR1.TheestablishedELISA,atanIC50valueof157.55ng.mL-1andadetectionlimit(IC20)of20.57ng.mL-1,wascomparedwithHPLCanalyses,andagoodcorrelationbetweenELISAandHPLC-ELSDanalysesofRUSintheextractofRadixOphiopogoniswasobtained.TheexperimentaldataindicatedthattheELISAmethodexhibitsmoreadvantagesoverHPLC-ELSD,suchaslowdetectionlimit,highspecificity,lowbackground,andnorequirementforsamplepre-treatment,andismoresuitableforthedeterminationofnaturalcomponentsinChinesetraditionalmedicinesandinbiologicalsamplesforpharmacokineticstudies.

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简介：我们在奇塔贡·希尔道在Khagarachari山区域的Aatmile从二个代表性的地点收集了土壤样品。这些地点之一在转移耕作和其它下面是邻近的13年的旧柚木种植园。两个地点在有寓言土壤的地文学的状况和一样的方面打的一样，它使我们能测量在土壤上转移耕作的效果微植物群。我们学习了土壤物理化学的性质和土壤微生物的生物化学、生物的性质。象真菌和细菌的人口一样的潮湿和有机物内容，两个在表面和表面下的土壤，显著地(p0.001)在不在转移耕作下面与土壤相比转移栽培土壤更低，即柚木种植园地点。在表面(010厘米)的最丰富的细菌并且表面下(1020厘米)分别地，当时，在转移耕作下面的土壤是Pseudomonasdiminuta和Shigella在柚木种植园的相应土壤层，占优势的微生物是杆菌firmus(010厘米)和Xanthomonas(1020厘米)。因为，微生物引起的人口差别不能被土壤质地差别解释组织上从二个地点的土壤的类似但是能在在转移耕作下面的土壤与显著地更低的潮湿和有机物内容有关。

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简介：Ba0.85Ca0.15Ti0.9Zr0.1O3(BCTZ)lead-freepiezoelectricceramicsco-dopedwithCeO2(x=0.1wt.%,0.2wt.%,0.3wt.%,0.4wt.%,0.5wt.%)andLi2CO3(0.6wt.%)werepreparedbyconventionalsolid-statereactionmethod.InfluenceofCeO2dopingamountonthepiezoelectricproperties,dielectricproperties,phasecompositionandmicrostructureofpreparedBCTZlead-freepiezoelectricceramicsdopedwithLi2CO3wereinvestigatedbyX-raydiffraction(XRD)andscanningelectronmicroscopy(SEM)andotheranalyticalmethods.TheresultsshowedthatthesinteredtemperatureofBCTZlead-freepiezoelectricceramicsdopedwithCeO2decreasedgreatlywhenLi2CO3dopingamountwas0.6wt.%;apureperovskitestructureofBCTZlead-freepiezoelectricceramicsco-dopedwithLi2CO3andCeO2andsinteredat1050°Ccouldalsobeobtained.Thepiezoelectricconstant(d33),therelativepermittivity(εr)andtheplanarelectromechanicalcouplingfactor(kp)ofBCTZceramicsdopedwithLi2CO3increasedfirstlyandthendecreased,thedielectricloss(tanδ)decreasedfirstlyandthenincreasedanddecreasedatlastwhenCeO2dopingamountincreased.TheinfluenceofCeO2dopingonthepropertiesofBCTZlead-freepiezoelectricceramicsdopedwithLi2CO3werecausedby'softeffect'and'hardeffect'piezoelectricadditiveandcausinglatticedistortion.WhenCeO2dopingamount(x)was0.2wt.%,theBCTZceramicsdopedwithLi2CO3(0.6wt.%)andsinteredat1050°Cpossessedthebestpiezoelectricpropertyanddielectricpropertywithd33of436pC/N,kpof48.3%,εrof3650,tanδof1.5%.

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简介：biomagnesium合金被认为由于它的好机械相容性，生物相容性，生物安全和可被细菌破坏的特征是最潜在的可被细菌破坏的金属材料之一。然而，在生理的环境和低机械性质的高降级率的二个主要问题阻止biomagnesium合金的发展。在现在的工作，Mg-Zn-Y-Nd合金的样品被周期的挤出压缩(CEC)和相等的隧道准备尖紧迫(ECAP)。微观结构，合金的机械性质和它在模仿的身体液体(SBF)的腐蚀行为被评估。结果表明那Mg-Zn-Y-Nd合金与测微计尺寸和缩放nano的秒阶段的同类的分发由equiaxial罚款谷物结构组成，它被动态再结晶在ECAP和CEC期间引起。合金的腐蚀抵抗被改进。张力并且腐蚀抵抗被改进，特别处理合金展览制服腐蚀表演和减少的腐蚀评价。这将作为脉管的stent申请为Mg-Zn-Y-Nd合金提供理论地面。

简介：二新-hydroxy氨基的联合酸的secoiridoids，命名serinosecologanin(1)和threoninosecologanin(2)，从忍冬装饰用的梨树的花芽的一篇水的摘录被孤立。他们包括绝对配置的不平常的结构被分光镜的数据分析决定，并且从共同发生的secologanin(3)和secologanic酸(4)由semisynthesis证实了。从曲霉属菌尼日尔从杏仁和hesperidinase对-glucosidase加重1和2项展出抵抗活动，他们也在激活血小板的因素与抑制率导致的老鼠polymorphonuclear白血球对glucuronidase的版本显示出活动(34.9 ；± ；3.1)%并且(53.6 ；± ；2.6)%分别地。

简介：Wereportanovelapproachtoobtainingaclassicalblue-greenexcitableCaS:Eu2+phosphorwithdesiredredemissionbymicrowave(MW)firingprocedureintheabsenceofaddingelementalsulphur.ThedisturbingeffectofMWelectromagneticfieldondecompositionofCaSO4intoCaSactivatedbyeuropiumisdistinctlyobservedtogivepurehostphasewithoutaddinganyelementalsulphurandcarbon.ThehostphaseevolutionisobservedtobehighlydependentonthevariationofappliedMWpowerfromX-raydiffraction(XRD)patternsandthecorrespondingphotoluminescence(PL),andamaximumPLintensityat1100WofMWpowerisacquiredfortheobtainedpurerhostphase.Thenon-thermalandnon-equilibriumeffectsbyMWarerevealedtocorrelatewiththeinteractionbetweenpolarstructureofthehostandappliedelectromagneticfield.Theresultsdemonstrateanoptionalproceduretopreparethisred-emittingphosphorinaneffective,environment-friendlyandscalableapproachforphosphorproductionintheapplicationofbio-illuminationforplantcultivationandartificialphotosynthesis.

简介：AseriesofCe0.5Fe0.30Zr0.20O2catalystswerepreparedbydifferentmethods(co-precipitationsmethod,citricacidsol-gelmethod,impregnationmethod,physicalmixedmethod,andhydrothermalmethod)andcharacterizedbyX-raydiffraction(XRD),Ramanspectroscopy,Brunauer-Emmett-Teller(BET)andH2-TPRmeasurements.Potentialofthecatalystsinthesootoxidationwasevaluatedinatemperature-programmedoxidation(TPO)apparatus.TheresultsshowedthatalltheFe3+andZr4+wereincorporatedintocerialatticetoformapureCe-Fe-Zr-Osolidsolutionfortheco-precipitationsample,buttwokindsofFephasesexistedintheCe-Fe-Zr-Ocatalystspreparedbyothermethods:Fe3+incorporatedintoCeO2latticeanddispersedFe2O3clusters.ThefreeFe2O3clusterscouldimprovetheactivityofcatalystsforsootoxidationcomparingwiththepureCe-Fe-Zr-OsolidsolutionowingtothesynergeticeffectbetweenfreeFe2O3andsurfaceoxygenvacancies.Inaddition,theactivityofcatalystsstronglyreliedonthesurfacereducibilityoffreeFe2O3particles.HoldingbothabundantfreeFe2O3particlesandhighoxygenvacancyconcentration,thehydrothermalCe0.5Fe0.3Zr0.2O2catalystpresentedthelowestTi(251°C,ignitiontemperatureofsootoxidation)andTm(310°C,maximumoxidationratetemperature)forsootcombustion(withtight-contactbetweensootandcatalysts)amongthefivesamples.Evenafteragingat800°Cfor10h,theTiandTmwerestillrelativelylow,at273and361°C,respectively,indicatinghighcatalyticstability.