简介：近日．由高级私人教练工作室——北京云雷汇推出的健康纤体体系——“FourWeeks体系”正式启动。“FourWeeks体系”的出品人房圣轩提出了一系列以“与食物成为朋友，通过合理的运动燃烧脂肪”为核心理念的纤体指导计划．针对情况不同的个人，提出个性化的纤体健身指导方案。

简介：AbstractDuring the past decades, early fetal ultrasound and diagnosis have increasingly gained attention in pregnancy care with the development of high-frequency transducers, which make it possible to obtain detailed images of the early fetus and its organs, and thus move part of the anatomy and anomaly scan from the second to the first-trimester. By transabdominal sonography or transvaginal sonography, or a combination of both approaches, it is now able to diagnose a wide variety of fetal abnormalities at 11-13+6 weeks.

简介：AbstractObjective:To evaluate the ability of cervical length (CL) at 28-32 weeks of gestation to predict spontaneous preterm delivery and preterm premature rupture of membranes (PPROM).Methods:It was a retrospective cohort study that vaginal ultrasonography at approximately 28-32 weeks of gestation was performed in 14,953 women between 17-49 years old with singleton pregnancies who delivered after 28 weeks of gestation at the Peking University First Hospital from June 2008 to December 2012. The pregnancy outcomes were followed and the relationship between the CL and preterm delivery or PPROM was assessed. The relative risk was calculated to assess group differences in the likelihood of an event occurring.Results:The overall prevalence of preterm delivery was 5.7% (858/14,953); the incidence for therapeutic preterm delivery was 2.1% (318/14,953), for spontaneous preterm delivery was 0.9% (133/14,953), and for PPROM was 2.7% (407/14,953). Excluding the 318 women who had therapeutic preterm delivery, the relative risk of preterm delivery for women with a CL between 25 mm and <30 mm, between 15 mm and <25 mm, and <15 mm was 3.7, 9.3, and 30.2, respectively. The sensitivity, specificity, and positive and negative predictive values of CL ≤25 mm at 28-32 weeks of gestation as the cut-off value for predicting preterm delivery were 19.8%, 97.5%, 23.4%, and 96.9%, respectively. For preterm delivery before 35 weeks of gestation, the sensitivity, specificity, and positive and negative predictive values of a CL ≤ 25 mm at 28-32 weeks of gestation as the cut-off value were 30.0%, 97.2%, 11.8%, and 99.1%, respectively. In addition, women with PPROM (n = 407) had significantly shorter CL (31.9 ± 7.4) mm at 28-32 weeks of gestation compared that of women without PPROM (34.0 ± 8.3) mm. The incidence of PPROM in women with a CL ≤25 mm at 28-32 weeks of gestation (19.4%, 79/407) was significantly lower than that for women with a CL >25 mm (80.6%, 328/407, P < 0.05).Conclusion:CL at 28-32 weeks of gestation can predict spontaneous preterm delivery, and is valuable for predicting PPROM.

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简介：AbstractBackground:Psoriasis is a chronic inflammatory skin disease, affecting about 0.6% of the Chinese population. Many patients are not well controlled by conventional treatments, thus there is need for new treatment regimens. In this study, we assessed the efficacy and safety of secukinumab in Chinese patients with moderate to severe plaque psoriasis.Methods:This study was a 52-week, multicentre, randomized, double-blind, placebo-controlled, parallel-group, Phase 3 trial. A sub-population of study participants (≥18 years) of Chinese ethnicity were randomized to receive subcutaneous injections of 300 or 150 mg secukinumab, or placebo. The co-primary endpoints were psoriasis area severity index (PASI) 75 and Investigator’s Global Assessment (IGA) 0/1 at Week 12.Results:A total of 441 Chinese patients were enrolled in this study. Co-primary outcomes were achieved; 300 and 150 mg secukinumab were superior to placebo as shown in the proportion of patients that achieved PASI 75 (97.7% and 87.2% vs. 3.7%, respectively; P < 0.001), and IGA 0/1 (82.3% and 69.7% vs. 2.7%; P < 0.001) at Week 12. Treatment efficacy was maintained until Week 52. There was no increase in overall adverse events with secukinumab relative to placebo throughout the 52-week period. Conclusion: Secukinumab is highly effective and well tolerated in Chinese patients with moderate to severe plaque psoriasis.Trial Registration:ClinicalTrials.gov, NCT03066609; https://clinicaltrials.gov/ct2/show/record/NCT03066609.

简介：Background:Giventhelowlevelsofphysicalactivity(PA)amongadolescentgirlsintheUS,thereisaneedtoidentifytoolstomotivateincreasedPA.AlthoughthereislimitedevidencethatadolescentstransferPAfromonecontexttoanother,exergames(i.e.,videogamesthatrequiregrossmotoractivity)mayactasagatewaytopromoteoverallPAoutsidegameplay.Thepurposeofthisstudywastoexaminepotentialtransfereffects(i.e.,influencesonexternalbehaviorsandpsychologicalconstructs)ofa12-weekexergaminginterventiononadolescentgirls’PA,screentime,andself-efficacytowardPA,aswellastheintrinsicmotivationofexergaming.Methods:Participantswere37girlsaged14–18years(65%AfricanAmerican,35%white)whowereoverweightorobese(bodymassindex≥85thpercentile)andwererecruitedfromthecommunityviaschool,physicians,newsmedia,andsocialmediawebsites.Adolescentswererandomlyassignedtoa12-weekgroupexergamingintervention(thirty-six60minsessionsofgroup-baseddanceexergaminginaresearchlaboratoryusingKinectforXbox360(MicrosoftCorporation,Redmond,WA,USA))ortoano-treatmentcontrolgroup.OutcomevariablesincludedobjectivelymeasuredPA(total)andself-reportedleisure-timePA(discretionarytimeonly)1weekbeforevs.1weekaftertheintervention;selectedtypeandintensityofPAwhenplacedinagymsettingfor30min('cardiofreechoice');screentime;self-efficacytowardPA;andintrinsicmotivationtowardexergaming.Results:Attendanceattheexergamingsessionswashigh(80%).Comparedwiththecontrolgroup,theinterventiongroupself-reportedanincreaseinPA(p=0.035)andfewerhourswatchingtelevisionorvideos(p=0.01)aftertheintervention,buttherewerenosignificantdifferencesinsedentary,light,moderate,orvigorousPAmeasuredbyaccelerometry.Theinterventiongroupsignificantlyimprovedself-efficacytowardPA(p=0.028).Theinterventiongrouphighlyratedintrinsicmotivationtowardexergaming.Conclusi

简介：你的骨盆够健康吗？坐在椅子上,让双脚踩在同一水平面上，观察自己的膝盖高度是否一致。然后仰卧在地板上,放平下肢，请朋友帮忙观察你的左右脚踝倾斜度是否一致。如果答案是否定的,就说明你的骨盆有一定程度的变形。其实大多数美眉都会因为长期穿着高跟鞋或单肩背负过重的背包而导致骨盆轻微变形。

简介：AbstractObjective:Various techniques are proposed for changing fetal presentation. We aimed to assess the effect of BL67 point stimulation on correcting breech presentation and natural delivery in women at 36-38 gestational weeks.Methods:A parallel single blinded randomized clinical trial was conducted on 72 eligible pregnant women with breech presentation at the 36 weeks of pregnancy. The subjects were divided into two groups - intervention (n = 36) and control groups (n = 36) by block randomization method. The intervention group stimulated the BL67 point by self-administration for 20 min once a day for 2 weeks. Finally, the appearance of cephalic presentation and rate of vaginal delivery was compared between the groups (n1 = n2 = 32) using the Chi-square test and multivariate logistic regression.Results:The correction of breech to cephalic presentation occurred in 53.1% of patients in the intervention group. The adjusted relative risk (RR) for fetal correction from breech to cephalic was 1.80 (RR = 1.80, 95% confidence interval [CI], 1.13-5.17). It was shown that the stimulation of the BL67 point increased the correction of breech to cephalic presentation. In addition, the rate of vaginal delivery increased by >4-fold (RR = 4.16, 95% CI, 2.54-6.82) by correction to cephalic presentation. Moreover, 65.6% of mothers in intervention group and 90.6% in the control group underwent cesarean section.Conclusions:The stimulation of the BL67 point is a safe, inexpensive, and effective method that can be self-administered at home for fetal correction from breech to cephalic presentation in women with breech presentations during 36-38 gestational weeks. This promotes uncomplicated natural childbirth.