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简介：大格式数字调音台S5Fusion是一款数字录音混录一体化专业解决方案，主要性能：EuphonixSystem5控制模块：可配置8～56个多格式推子控制面，采用5FT、7FT或9FT机架：具备Euphonix全面自动化功能：每控制通道条具备8个触摸旋钮：TFT高清晰、多格式（声像）电平表显示：主控制模块标准配置；eMix显示、双声像摇杆：至少56路DSP处理通道和36路母线：EuconHybrid多台不同品牌音频工作站无缝遥控：

简介：Whitenoisedeconvolutionorinputwhitenoiseestimationproblemhasimportantappli-cationbackgroundsinoilseismicexploration,communicationandsignalprocessing.Bythemoderntimeseriesanalysismethod,basedontheAuto-RegressiveMovingAverage(ARMA)innovationmodel,underthelinearminimumvarianceoptimalfusionrules,threeoptimalweightedfusionwhitenoisedeconvolutionestimatorsarepresentedforthemultisensorsystemswithtime-delayedmeasurementsandcoloredmeasurementnoises.Theycanhandletheinputwhitenoisefusedfiltering,predictionandsmoothingproblems.Theaccuracyofthefusersishigherthanthatofeachlocalwhitenoiseestimator.Inordertocomputetheoptimalweights,theformulaofcomputingthelocalestimationerrorcross-covariancesisgiven.AMonteCarlosimulationexampleforthesystemwith3sensorsandtheBernoulli-Gaussianinputwhitenoiseshowstheireffectivenessandperformances.

简介：大型企业不断转向在数据中心内使用服务器连接的闪存，从而实现CPU利用率的最大化，同时降低运营成本。

简介：高周波的表面波浪雷达(HFSWR)和自动鉴定系统(AIS)是使用容器追踪的二个很重要的传感器。HFSWR能被用于在一个察觉区域追踪所有容器，当AIS通常被用来验证合作容器的信息时。因为从海喧嚷的干扰，为容器追踪采用单个频率的HFSWR可以遮住位于布拉格山峰的盲目地区的容器。在察觉频率分析变化为探讨这缺乏组成一个有效方法。由容器熔化追踪组成的一个解决方案用AIS校准的双频率的HFSWR数据被建议。因为不同系统的偏爱在HFSWR频率大小和AIS大小之间存在，AIS信息被用来估计并且改正HFSWR在每频率的系统的偏爱。首先，为合作容器的AIS点大小用一个日本胜利公司任务算法与HFSWR大小被联系。从合作容器的协会结果，在dualfrequencyHFSWR数据的系统的偏爱被估计并且改正。基于改正的双频率的HFSWR数据，然后，容器用一个双频率的熔化关节被追踪概率的数据协会(JPDA)-unscentedKalman过滤器(UKF)算法。用真实察觉数据的试验性的结果证明建议方法在在实时追踪容器是有效的并且能与追踪包含单个频率的数据的过程相比改进追踪的能力和精确性。

简介：Underthecomplicatedelectromagnetismcircumstance,themodelofdatafusioncontrolandguidanceofsurface-to-airmissileweaponsystemsisestablished.SuchwaysandtheoriesasElman-NN,radartrackingandfilter’sdatafusionnetbasedonthegroupmethodfordata-processing(GMRDF)areappliedtoconstructingthemodelofdatafusion.Thehighlyreliablestateestimationofthetrackingtargetsandtheimprovementinaccuracyofcontrolandguidanceareobtained.Thepurposeisoptimizationdesignofdatafusioncontrolandguidanceofsurface-to-airmissileweaponsystemsandimprovingthefightingeffectivenessofsurface-to-airmissileweaponsystems.

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简介：AbstractBackground:Three-dimensional (3D) fusion imaging has been proved to be a promising neurosurgical tool for presurgical evaluation of tumor removal. We aim to develop a scoring system based on this new tool to predict the resection grade of medial sphenoid wing meningiomas (mSWM) intuitively.Methods:We included 46 patients treated for mSWM from 2014 to 2019 to evaluate their tumors' location, volume, cavernous sinus involvement, vascular encasement, and bone invasion by 3D multimodality fusion imaging. A scoring system based on the significant parameters detected by statistical analysis was created and evaluated.Results:The tumor volumes ranged from 0.8 cm3 to 171.9 cm3. A total of 39 (84.8%) patients had arterial involvement. Cavernous sinus (CS) involvement was observed in 23 patients (50.0%) and bone invasion was noted in 10 patients (21.7%). Simpson I resection was achieved in 10 patients (21.7%) and Simpson II resection was achieved in 17 patients (37.0%). Fifteen patients (32.6%) underwent Simpson III resection and 4 patients (8.7%) underwent Simpson IV resections. A scoring system was created. The score ranged from 1 to 10 and the mean score of our patients was 5.3 ± 2.8. Strong positive monotonic correlation existed between the score and resection grade (Rs = 0.772, P < 0.001). The scoring system had good predictive capacity with an accuracy of 69.60%.Conclusions:We described a scoring system that enabled neurosurgeons to predict extent of resection and outcomes for mSWM preoperatively with 3D multimodality fusion imaging.Trial registration:Retrospectively registered

简介：Toestablishasensitiveandspecificmethodforseroepidermiologicaldetectionofhumanher-pesvirus8(HHV-8)infection,threepotentantigenicproteinsencodedbyopenreadingframes(ORFs)K8.1,65and73CingenomeofHHV-8wereproducedasglutathioneS-transferasefusionproteinintheprokaryoticexpressionsystemandwasusedasantigenfortesting.Therecombinantfusionproteinex-pressedintheprokaryoticexpressionvectorE.coliBL21waspurifiedbyglutathioneSepharose4Baffin-itychromatographyandwasquantitatedwithSDS-PAGE.Allthese3fusionproteinsproducedinthepro-karyoticexpressionsystemshowedgoodimmunogenicityasdemonstratedbyWesternblottingandcouldberecognizedbymixedseraofpatientswithKaposi′ssarcoma(KS).Theimmuno-reactivitiesofthesingleorcompoundfusionproteinweredeterminedbymeansofELISAandcomparedwiththetraditionalimmu-nofluorescenceassay(IFA)todeterminetheirsensitivityandspecificityofthetest.Itwasdemonstratedthatthesensitivityofmixed-antigenELISAmethodwassignificantlyhigherthanthatofIFA(81.8%vs34.4%),whilethespecificityoftheformerwasdemonstratedtobe97.9%.Thecoincidenceofthede-tectionratebetweenthesetwomethodswasconsiderablyhigh,approachingupto90.0%.TheseresultssuggestthatthemixedantigenELISAassayappearstobeasensitiveandspecificmethodforsero-epide-miologicaldetectionofhumanherpesvirus8infection.

简介：AbstractBackground:Subarachnoid hemorrhage (SAH), an acute cerebrovascular accident, features with its high death and disability rate. Sirtuin3 (SIRT3) is a NAD+ dependent deacetylase which mainly located in mitochondria. Reduced SIRT3 function was indicated to involve in many disorders of central nervous system. Herein, we aimed to explore the neuroprotective effects of SIRT3 on SAH and to furtherly explore the underlying mechanisms.Methods:Adult C57BL/6 J male mice (8-10 weeks) were used to establish SAH models. The pharmacological agonist of SIRT3, Honokiol (HKL), was injected in an intraperitoneal manner (10 mg/kg) immediately after the operation. Brain edema and neurobehavioral score were assessed. Nissl staining and FJC staining were used to evaluate the extent of neuronal damage. The changes of mitochondria morphology were observed with transmission electron microscopy. Western blot was used for analyzing the protein level of SIRT3 and the downstream signaling molecules.Result:SIRT3 was downregulated after SAH, and additional treatment of SIRT3 agonist HKL alleviated brain edema and neurobehavioral deficits after SAH. Additionally, electron microscopy showed that HKL significantly alleviated the morphological damage of mitochondria induced by SAH. Further studies showed that HKL could increase the level of mitochondrial fusion protein Mfn1 and Mfn2, thus maintaining (mitochondrial morphology), protecting mitochondrial function and promoting neural survival. While, additional Compound C (CC) treatment, a selective AMPK inhibitor, abolished these protective effects.Conclusions:Activation of SIRT3 protects against SAH injury through improving mitochondrial fusion in an AMPK dependent manner.

简介：Twotransmissioncurvedcrystalspectrometersaredesignedtomeasurethehardx-rayemissioninthelaserfusionexperimentofComptonradiographyofimplosiontargetonShenGuang-IIIlaserfacilityinChina.Cylindricallycurvedα-quartz(10–11)crystalswithcurvatureradiiof150and300mmareusedtocoverspectralrangesof10–56and17–100keV,respectively.Thedistancebetweenthecrystalandthex-raysourcecanbechangedoverabroaddistancefrom200to1500mm.Theopticaldesign,includingtheintegralreflectivityofthecurvedcrystal,thesensitivity,andthespectralresolutionofthespectrometers,isdiscussed.WealsoprovidemechanicdesigndetailsandexperimentalresultsusingaMoanodex-raysource.High-qualityspectrawereobtained.Weconfirmedthatthespectralresolutioncanbeimprovedbyincreasingtheworkingdistance,whichisthedistancebetweentherecordingmediumandtheRowlandcircle.

简介：D-S证据理论提供一条好途径熔化不明确的信息。在这篇文章，我们基于D-S证据理论介绍地震多属性熔化预言coalbed甲烷(CBM)集中了区域。首先，我们选择对内容与在井地点测量的CBM内容的指导改变的CBM很敏感的地震属性。然后，选择地震属性用D-S证据理论被熔化，熔化结果被用来预言充实CBM的区域。申请证明预言的CBM内容和测量价值是基本上一致的。结果在地震多属性熔化显示那个使用的D-S证据理论预言充实CBM的区域是可行的。

简介：Anovel,Ti-6A1-4V(Ti64)/Hydroxyapatite(HAat5%byweightconcentration)metal/ceramiccompositehasbeenfabricatedusingelectronbeampowderbedfusion(EPBF)additivemanufacturing(AM):specifically,thecommercialelectronbeammelting(EBMR)process.InadditiontosolidTi64andTi64/5%HAsamples,fourdifferentunitcell(model)open-cellularmeshstructuresfortheTi64/5%HAcompositewerefabricatedhavingdensitiesrangingfrom0.68to1.12g/cm^3,andcorrespondingYoung'smodulirangingfrom2.9to8.0GPa,andcompressivestrengthsrangingfrom-3to11MPa.ThesolidTi64/5%HAcompositeexhibitedanoptimaltensilestrengthof123MPa,andelongationof5.5%incontrasttoamaximumcompressivestrengthof875MPa.Boththesolidcompositeandmeshsamplesdeformedprimarilybybrittledeformation,withthemeshsamplesexhibitingerratic,brittlecrushing.Solid,EPBF-fabricatedTi64sampleshadaVickersmicroindentationhardnessof4.1GPawhiletheTi64/5%HAsolidcompositeexhibitedaVickersmicroindentationhardnessof6.8GPa.ThelowestdensityTi64/5%HAcompositemeshstrutsectionshadaVickersmicroindentationhardnessof7.1GPa.Opticalmetallography(OM)andseanningelectronmicroscopy(SEM)analysisshowedtheHAdispersoidstobehighlysegregatedalongdomainorgrainboundaries,buthomogeneouslydistributedalongalpha(hcp)plateletboundarieswithinthesedomainsintheTi64matrixforboththesolidandmeshcomposites.Thealphaplateletwidthvariedfrom-5μmintheEPBF-fabricatedTi64to-1.1μmfortheTi64/5%HAmeshstrut.TheprecursorHApowderdiameteraveraged5μm,incontrasttothedispersedHAparticlediametersintheTi64/5%HAcompositewhichaveraged0.5μm.ThisworkhighlightstheuseofEPBFAMasanovelprocessforfabricationofatruecompositestructure,consistingofaTi64matrixandinterspersedandexposedHAdomains,whichtotheauthorsknowledgehasnotbeenreportedbefore.Theresultsalsoillustratetheprospectsnotonlyforfabrica

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简介：美国是STEM教育的发源地,同时也十分重视STEM教育在基础教育中的应用与发展,《ScienceFusion》是美国加州公立小学正在使用的一套科学教材,本文选取《ScienceFusion》五年级中的一个STEM课程案例,从课程目标、课程内容、课程资源三个方面对其进行分析研究,所得到的研究成果希望能对我国小学科学课程改革带来一些启示。

简介：AbstractBackground:Andersson lesions (ALs), also known as spondylodiscities, destructive vertebral lesions and spinal pseudarthrosis, usually occur in patients with ankylosing spondylitis (AS). Inflammatory and traumatic causes have been proposed to define this lesion. Different surgical approaches including anterior, posterior, and combined anterior and posterior procedure have been used to address the complications, consisting of mechanical pain, kyphotic deformity, and neurologic deficits. However, the preferred surgical procedure remains controversial. The aim of this study was to illustrate the safety, efficacy, and feasibility of a modified posterior wedge osteotomy for the ALs with kyphotic deformity in AS.Methods:From June 2008 to January 2013, 23 patients (18 males, 5 females) at an average age of 44.8 years (range 25–69 years) were surgically treated for thoracolumbar kyphosis with ALs in AS via a modified posterior wedge osteotomy in our department. All sagittal balance parameters were assessed by standing lateral radiography of the whole spine before surgery and during the follow-up period. Assessment of radiologic fusion at follow-up was based on the Bridwell interbody fusion grading system. Ankylosing spondylitis quality of life (ASQoL) and visual analog scale (VAS) scores were performed to evaluate improvements in daily life function and back pain pre-operatively and post-operatively. Paired t tests were used to compare clinical data change in parametric values before and after surgery and the Mann-Whitney U test was employed for non-parametric comparisons. The radiographic data change was evaluated by repeated measure analysis of variance.Results:The mean operative duration was 205.4 min (range 115–375 min), with an average blood loss of 488.5 mL (range 215–880 mL). Radiographical and clinical outcomes were assessed after a mean of 61.4 months of follow-up. The VAS back pain and ASQoL scores improved significantly in all patients (7.52 ± 1.31 vs. 1.70 ± 0.70, t= 18.30, P < 0.001; 13.87 ± 1.89 vs. 7.22 ± 1.24, t= 18.53, P < 0.001, respectively). The thoracolumbar kyphosis (TLK) changed from 40.03 ± 17.61° pre-operatively to 13.86 ± 6.65° post-operatively, and 28.45 ± 6.63° at final follow-up (F = 57.54, P < 0.001), the thoracic kyphosis (TK) changed from 52.30 ± 17.62° pre-operatively to 27.76 ± 6.50° post-operatively, and 28.45 ± 6.63° at final follow-up (F = 57.29, P < 0.001), and lumbar lordosis (LL) changed from -29.56 ± 9.73° pre-operatively to -20.58 ± 9.71° post-operatively, and -20.73 ± 10.27° at final follow-up (F = 42.50, P < 0.001). Mean sagittal vertical axis (SVA) was improved from 11.82 ± 4.55 cm pre-operatively to 5.12 ± 2.42 cm post-operatively, and 5.03 ± 2.29 cm at final follow-up (F = 79.36, P < 0.001). No obvious loss of correction occurred, according to the lack of significant differences in the sagittal balance parameters between post-operatively and the final follow-up in all patients (TK: 27.76 ± 6.50° vs. 28.45 ± 6.63°, TLK: 13.86 ± 6.65° vs. 14.42 ± 6.7°, LL: -20.58 ± 9.71° vs. -20.73 ± 10.27°, and SVA: 5.12 ± 2.42 cm vs. 5.03 ± 2.29 cm, all P > 0.05, respectively).Conclusions:The modified posterior wedge osteotomy is an accepted surgical procedure for treating thoracolumbar kyphosis with ALs in AS and results in satisfactory local kyphosis correction, solid fusion, and good clinical outcomes.

简介：Toclonethegenecodingtheimmunodominantregioninthechlamydialprotease-likeactivityfactor(CPAF)fromChlamydophilapneumoniae,toanalyzeimmunocompetenceoftheexpressedprotein,andtoevaluateitsvalueinserodiagnosis,theCPAFimmunodominantregiongenewasamplified,ligatedintoapGEX6p-2vector,andthentheexpressedrecombinantproteinwaspurifiedwithglutathioneS-transferase(GST)agarosegelFFafterrenaturation,thenidentifiedbySDS-PAGEandWesternblot.AnewindirectELISAwasdevelopedwiththepurifiedproteinascoatingantigen.TheimmunogenicityoftherecombinantproteinwasevaluatedbyimmunizationtoNewZealandrabbits,anditsimmunoreactivitywasanalyzedbyreactingwithanti-C,pneumoniaeantibody.300clinicalserasampleswererespectivelyde-tectedbymicroimmunofluorescence(MIF)asreferencemethodandtheindirectELISA,andthediffer-encebetweenthetwomethodswasanalyzed.Cross-reactivityagainstChlamydiatrachomatiswasinvesti-gatedwiththeindirectELISAtodetectanti-C,trachomatispositiveantisera.Theresultsindicatedthata51.3kDarecombinantproteinwasobtained.Westernblotassayprovedthattherecombinantproteincouldmerelyspecificallyreactwithhumananti-C.pneumoniaeantisera.ThetitersofthespecificIgGan-tibodiesintheimmunizedNewZealandrabbitswereabove1:16000.Anti-C.pneumoniaeIgGpositiveandnegativereferencesereweredetectedwiththeindirectELISA,andtheconcordancerateofnegativeandpositiveresultswereboth100%(40/40).ThesensitivityandspecificityoftheindirectELISAincomparisonwithMIFwere93.8%(45/48)and100%(252/252)separatelybydetecting300clinicalserasamples,andtheconcordanceratebetweenthetwomethodswas99.0%.NocrossreactionagainstC.trachomatiswasfoundwiththeindirectELISAtodetectanti-C,trachomatispositiveantisera.Incon-clusion,thepreparedrecombinantproteinoftheCPAFimmunodominantregionshowsexcellentimmuno-competenceandcanbeusedtodevelopanewindirect

简介：TheZ-backlighterlaserfacilityprimarilyconsistsoftwohighenergy,high-powerlasersystems.Z-Beamletlaser(ZBL)(Ramboetal.,Appl.Opt.44,2421(2005))isamulti-kJ-class,nanosecondlaseroperatingat1054nmwhichisfrequencydoubledto527nminordertoprovidex-raybacklightingofhighenergydensityeventsontheZ-machine.Z-Petawatt(ZPW)(Schwarzetal.,J.Phys.:Conf.Ser.112,032020(2008))isapetawatt-classsystemoperatingat1054nmdeliveringupto500Jin500fsforbacklightingandvariousshort-pulselaserexperiments(seealsoFigure10forafacilityoverview).Withthedevelopmentofthemagnetizedlinerinertialfusion(MagLIF)conceptontheZ-machine,theprimarybacklightingmissionsofZBLandZPWhavebeenadjustedaccordingly.Asaresult,wehavefocusedourrecenteffortsonincreasingtheoutputenergyofZBLfrom2to4kJat527nmbymodifyingthefiberfrontendtonowincludeextrabandwidth(forstimulatedBrillouinscatteringsuppression).TheMagLIFconceptrequiresawell-defined/behavedbeamforinteractionwiththepressurizedfuel.HencewehavemadegreateffortstoimplementanadaptiveopticssystemonZBLandhaveexploredtheuseofphaseplates.WearealsoexploringconceptstouseZPWasabacklighterforZBLdrivenMagLIFexperiments.Alternatively,ZPWcouldbeusedasanadditionalfusionfuelpre-heaterorasatemporallyflexiblehighenergypre-pulse.AlloftheseconceptsrequiretheabilitytooperatetheZPWinananosecondlong-pulsemode,inwhichthebeamcanco-propagatewithZBL.Someoftheproposedmodificationsarecompleteandmostofthemarewellontheirway.

简介：The12C+13Csystemhasbeenstudiedextensively,becauseofthesimilarityoftheentrancechanneltotheastrophysicallyimportant12C+12Creaction[1??3].Untilnow,threedifferentmethodshavebeenexploitedtoperformthefusioncrosssectionmeasurementsfor12C+13CundertheCoulombbarrier:(1)measuringtheyieldofcharacteristicrays,(2)thetotal-rayyieldsusingNaIsummingdetectorsand(3)theactivityofthereactionresidue24Na(T1=2=15.0h).Recently,thefusioncrosssectionof12C+13Chasbeenmeasureddownto0.9nbthroughtheactivitymeasurementbyourgroup[4].Althoughthestatisticalmodelcalculationsinallthesethreemethodshavebeenroutinelyusedtoconverttheobservedpartialcrosssectionsintothetotalfusioncrosssections[5],thesystematicuncertaintyinducedbythestatisticalcorrectionshasnotbeenstudiedverywell.

简介：ToconstructandexpressthefusionproteinStx2B-IntiminC300ofEHEC0157:H7,andtofurtherinvestigateitsimmunoprophyiacticpotential,thegeneofStx2B(stx2b)fromEHEC0157:H7chromosomewasclonedintopMD18-Tvector.Thereafter,theamplifiedgenewasclonedintoprokaryoticexpressionplasmidpET-28a(+)-eaeC300,whichwasconstructedpreviously.TherecombinantpasmidpET-28a(+)-stx2b-eaeC300wastransformedintoE.coliBL21(DE3).Afterinducement,theproteinStx2B-IntiminC300wassuccessfullyexpressedandanalyzedwithsodiumdodecylsulfatepolyacrylamidegelelectrophoresis(SDS-PAGE),WesternblottingandN-terminalaminoacidresidualsequencing.Toevaluateitsimmunoprophyiacticpotential,itwasprimarilypurifiedbyion-exchangechromatographyandinjectedinto30BALB/cmicewithAl(OH)3inthesubscapularregion.Tendaysafterthelastboostervaccination,20micewereattackedwithEHEC0157:H7lysateandtheprotectiveefficacywasobserved.Inthepresentstudy,thegeneofStx2B-IntiminC300wassuccessfullyclonedintopET-28a(+)vector.TheresultsofSDS-PAGEandWesternblottingassayshowedthatthefusionproteinwassuccessfullyexpressedintheinclusionbodyform,accountingfor25%oftotalexpressionproducts,anditsmolecularweightwasabout43kDa.TheresultoftheN-terminalaminoacidresidualsequencingshowedthatitwasidenticaltothatofthemoleculardesigned.Thepuritywasabout75%afterprimarypurification.AnimaltestsrevealedthatthefusionproteinStx2B-IntiminC300haselicitedhightiterofprotectiveantibodyrelatively.TheseresultsdemonstratethatthefusionproteinStx2B-IntiminC300issuccessfullyexpressedinprokaryoticexpressionsystemandshowscertainimmunoprophyiacticpotential.