Inhibitory effect of icariin on expression of myelin inhibitory factors in the central nervous system of rats with focal cerebral ischemia-中国期刊网

摘要 Icariin,themajoractivecomponentofChinesemedicinalherbepimediumbrevicornummaxim,isusedwidelyintraditionalChinesemedicineforthetreatmentofneurologicaldiseases.However,theeffectsoficariinonmyelininhibitoryfactorsareasyetunclear.Inthepresentstudy,administrationoficariinat20mg/kgshowedamarkedreductioninneurologicaldeficitofmiddlecerebralarteryocclusionrats.Icariinexhibitedbetterinhibitoryeffectsonmyelininhibitoryfactors:Nogo-A,myelin-associatedglycoproteinandoligodendrocytemyelinglycoproteininischemiaregionsofmiddlecerebralarteryocclusionratscomparedwithmonosialotetrahexosylganglioside.Theseresultsindicatethaticariinexhibitspotentinhibitoryeffectsonexpressionofmyelininhibitorsaftermiddlecerebralarteryocclusion-inducedfocalcerebralischemiainvivo.Thiseffectmaybemediated,atleastinpart,bytheinhibitionofbothNogo-A,myelin-associatedglycoproteinandoligodendrocytemyelinglycoproteinactivation,followedbytheenhancementofaxonalsproutingandregeneration,resultinginneurologicalfunctionalrecovery.

1Lihua Sun;Yanli Zhang;Gaoxiao Zhang;Guopin Pan;Huiwei Wu;Chao Li;Ling Wang;Baofeng Yang. Mechanisms of Arrhythmia Induced by Focal Cerebral Ischemia in Rats.药学,2008-02.
2Yan Luo Nenggui Xu Wei Yi Yong Zi Yixu Du. Effects of electroacupuncture on astrocytes in the marginal zone of focal cerebral ischemia in rats.神经病学与精神病学,2009-04.
3Ling Tang;Jun Zuo;Yonghong Wang;Yuanda Zhou;Haixia He. Angiopoietin-1 mRNA expression in estradiol-treated ovariectomized rats with focal cerebral ischemia after reperfusion.神经病学与精神病学,2008-10.
4王舒;王占奎;倪光夏;朱忠春(Translator). Influence of Brain-activating Acupuncture on Cerebral Histomorphology in Rats with Focal Cerebral Ischemia and Reperfusion.中医学,2006-04.
5王立祥;Zeng Jiping;Wei Xinbing;Zhu Qingfen;Chen Lin;张岫美. Role of Angiotensin Converting Enzyme 2 in Focal Cerebral Ischemia Injury in Rats.药学,2008-02.
6杨卓欣;于海波;王玲;张家维. EFFECT OF ELECTROACUPUNCTURE ON SYNAPTIC PLASTICITY OF HIPPOCAMPAL NEURONS IN CEREBRAL ISCHEMIA RATS.针灸推拿学,2004-03.
7Yan Luo;Nenggui Xu;Wei Yi;Tao Yu;Zhonghua Yang. Electroacupuncture effect on synaptic ultrastructure in focal cerebral ischemia marginal zone of the rat.神经病学与精神病学,2010-08.
8MaYang XuNenggui XuGuansun ZhongPing WangLianfa ZhuShunli ChenQuanzhu. EFFECT OF ELECTROACUPUNCTURE OF DUMAI-ACUPOINTS ON CEREBRAL NO AND BLOOD ENDOTHELIN CONTENTS IN RATS WITH ACUTE CEREBRAL ISCHEMIA.针灸推拿学,2000-03.
9邹晓静;施静;刘敬;李伶俐;刘晓春. EFFECT OF ELECTROACUPUNCTURE ON NOREPINEPHRINE LEVEL AND APOPTOSIS IN CEREBRAL CORTEX TISSUE IN RATS WITH CEREBRAL ISCHEMIA-REPERFUSION.针灸推拿学,2004-04.
10Liangzhi Xiong;Yongxia Shi;Feng Xiao;Qingxiu Wang. Effects of transection of cervical sympathetic trunk on cerebral infarct volume and oxygen free radical levels in rats with focal cerebral ischemia/reperfusion injury.神经病学与精神病学,2008-05.

Inhibitory effect of icariin on expression of myelin inhibitory factors in the central nervous system of rats with focal cerebral ischemia

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Inhibitory effect of icariin on expression of myelin inhibitory factors in the central nervous system of rats with focal cerebral ischemia

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