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1 个结果
  • 简介:Ourpreviousreportshaveshownthatlamininglycopeptides(LN-GPs),thetotalglycopeptidespreparedfromlaminin(LN),canpreventtheexperimentallungmetastasisandlivermetastasisofmousecancercells.Inordertoexploretheanti-metastaticmechanismofLN-GPs,westudiedtheeffectsofLN-GPsonmetastasisrelatedbehaviorsofcancercellsinvitro.LN-GPsdidnotaffectcellsurvival.However,LN-GPsinhibitedcellattachmentandspreadingofS180cellsonLN-andMatrigelsubstrateindose-dependentandtime-dependentmanners.Moreover,inhibitionofcellattachmentandspreadingonMatrigelsubstratesweremuchgreateronMatrigelsubstratethanonLNsubstrate.InthegresenceofLN-GPs,S180cellsonLNsubstratechangedfromaflattenedpolygonalshapetoaroundone,themigrationofS180cellsonLNsubstratedecreased,andthenumberofahighlyinvasivehumanpulmonarygiantcarcinomaPGcellsinvadingMatrigelfilterinaBoydenchamberwasreduced.LN-GPsthushavemultipleinhibitoryeffectsoncancermetastasisrelatedbehaviors.

  • 标签: LAMININ 癌细胞转移 相关行为 非胶原糖蛋白 LN-GP