简介：objective:Theeffectsofdifferentchitosanonpreventingtraumaticperitonealadhesioninratswasstudiedinthispaper.METHODS:96SDratswithinjuredvermiformprocesswererandomlydividedinto4groupsasfollows:groupAwithoutanytreatmentascontrol,groupBtreatedwithchitosangel,groupCtreatedwithpurechitosanfilmandgroupDtreatedwithchistonfilmcontaining50%gelatin.2and4weeksaftersurgery,12ratsineachgroupwererespectivelybellyopenedtoobservechitosandegradationandevaluateperitonealadhesion,andtheadhesivevermiformprocessestissueswerehistopathologicallyobserved.RESULTS:1.DegraaxationinthegroupDwasfasterthanthatinthegroupCbutslowerthanthatinthegroupB.2.2weeksaftersurgerytheadhesioninthegroupBwasmilderthanthatinthecontrolgroup(goupA)(P＜0.05),butthatinthegroupCandD(bothP＜0.05)weremoreseverethanthatinthecontrolgroup.3.4weeksaftersurgery,theadhesioninthegroupBwasmilderthanthatinthecontrolgroup(P＜0.05),butthatinthegroupCandD(bothP＜0.05)weremoreseverethanthatinthecontrolgroup,whereas,therewasnosignificantdifferencebetweenadhesioninthegroupCandgroupD(P＞0.05).4.Histopathologicalexaminaitonindicatedthat:2weeksaftersurgery,inflammatorycellinfiltrationandfibroplasticproliferationdominatedinlocallesionandtheresponsewasmostseyereontheserouscoat,furthermore,theresponseinthecontrolgroupwasmoreseverethanthatinthegroupB,butmilderthanthatinthegroupCandD;4weeksaftersurgery,fibroplasticproliferationdominatedinlocallesionineachgroup,moreover,theresponseinthecontrolgroupwasmoreseverethanthatinthegroupBbutmilderthanthatinthegroupCandD.What'smore,integratedfibrousmembraneformedaroundimplantedmaterialsinthegroupCandD,andthefibrousmembraneswerethinnerinthegroupCthanthatinthegroupD.CONCLUSION:1.Chitosangelhasperfecteffe