简介：Humanleukocyteantigen(HLA)systemisthemostpolymorphicregionknowninthehumangenome.Inthepresentstudy,weanalyzedforthefirsttimetheHLA-Agenepolymorphismsdefinedbythehigh-resolutiontypingmethods-sequence-basedtyping(SBT)in161NorthernChineseHanpeople.Atotalof74differentHLA-Agenetypesand36allelesweredetected.ThemostfrequentalleleswereA110101(GF=0.2360)，A24020101（GF=0.1646），andA020101(GF=0.1553)；followedbyA3303(GF=0.1180)，A3001（GF=0.0590)，andA310102(GF=0.0404).Thefrequenciesoffollowingalleles,A0203,A0205,A0206,A0207,A030101,A2423,A2601,A3201,andA3301,areallhigherthan0.0093.ThehomozygousallelesincludeA020101,A110101,A24020101andA310102.Heterozygosity(H),polymorphisminformationcontent(PIC),discriminationpower(DP)andprobabilityofpaternityexclusion(PPE)ofHLA-Ainthesampleswerecalculatedandtheirvalueswere0.8705，0.8491，0.6014，and0.9475，respectively.Hanpopulation，especiallytheallelesubtypescharacter,willbeofgreatinterestforclinicaltransplantation,disease-associatedstudyandforensicidentification.Implementationofhigh-resolutiontypingmethodsallowsasignificantlywiderspectrumofHLAvariationincludingrarealleles.Thisrpectrumwillfurtherbeextensivelyutilizedinmanyfields.