简介：Inthisstudy,multiwalledcarbonnanotubes(MWCNTs)wereusedtoencapsulateamodelanticancerdrug,doxorubicin(Dox).Then,thedrug-loadedMWCNTs(Dox/MWCNTs)withanoptimizeddrugencapsulationpercentageweremixedwithpoly(lactide-co-glycolide)(PLGA)polymersolutionforsubsequentelectrospinningtoformdrug-loadedcompositenanofibrousmats.Thestructure,morphology,andmechanicalpropertiesoftheformedelectrospunDox/PLGA,MWCNTs/PLGA,andDox/MWCNTs/PLGAcompositenanofibrousmatswerecharacterizedusingscanningelectronmicroscopy(SEM),Fouriertransforminfraredspectroscopy,andtensiletesting.InvitroviabilityassayandSEMmorphologyobservationofmousefibroblastcellsculturedontotheMWCNTs/PLGAfibrousscaffoldsdemonstratethatthedevelopedMWCNTs/PLGAcompositenanofibersarecytocompatible.TheincorporationofDox-loadedMWCNTswithinthePLGAnanofibersisabletoimprovethemechanicaldurabilityandmaintainthethree-dimensionalstructureofthenanofibrousmats.Moreimportantly,ourresultsindicatethatthisdouble-containerdrugdeliverysystem(bothPLGApolymerandMWCNTsaredrugcarriers)isbeneficialtoavoidtheburstreleaseofthedrugandabletoreleasetheantitumordrugDoxinasustainedmannerfor42days.Thedevelopedcompositeelectrospunnanofibrousdrugdeliverysystemmaybeusedastherapeuticscaffoldmaterialsforpost-operativelocalchemotherapy.

简介：一系列-cyclodextrin-conjugated4手臂poly(乙烯乙二醇)-poly(lactide-co-glycolide)(4手臂PEG-PLGA)共聚物被D，L减水乳酸和glycolide的戒指洞聚合作为开始者用4手臂木钉综合，然后结合了与单音(6-ethylenediamine-6-deoxy)--cyclodextrin(CDen)或衔接ethylenediamino的二度--CD(BCDen)。共聚物的化学结构被1H-NMR和FTIR光谱学。-CD-conjugatedPEG-PLGA由于CD和牛的浆液白朊(BSA)包括complexation的形成形成了稳定的反向的微粒，它能在器官的溶剂答应BSA改进封装效率。而且，我们表明了一条一步舞途径构造用这些的包含蛋白质的电影颠倒的macroporous微粒。有订的毛孔数组的电影直接从反向的微粒被准备。有趣地，蛋白质完全除了毛孔位于整个矩阵。