简介：Spinalcordinjury(SCI)isadebilitatingconditionthataffectsmorethan2.5millionindividualsworldwide(Thuretetal.,2006).Inadditiontoitsdevastatingeffectsontheindividual,thisdiseaseisaheavyburdentothesocietyintermsofhealth

简介：Clinicaloutcomesarepositivelyassociatedwithhematomaabsorption.Themonocyte-macrophagescavengerreceptor,CD163,playsanimportantroleinthemetabolismofhemoglobin,andasolubleformofCD163ispresentinplasmaandothertissuefluids;therefore,wespeculatedthatserumCD163affectshematomaabsorptionafterintracerebralhemorrhage.Patientswithintracerebralhemorrhageweredividedintohigh-andlow-levelgroupsaccordingtotheaverageCD163level(1,977.79±832.91ng/mL).Comparedwiththehigh-levelgroup,thelow-levelgrouphadasignificantlyslowerhematomaabsorptionrate,andsignificantlyincreasedNationalInstitutesofHealthStrokeScalescoresandmodifiedRankinScalescores.TheseresultssuggestthatCD163promoteshematomaabsorptionandtherecoveryofneurologicalfunctioninpatientswithintracerebralhemorrhage.

简介：Themechanismsfortheregulationofsynapticdopamine(DA)includeitsreleasefrompresynapticvesicles,itsinteractionwithpost-synapticandpre-synapticDAreceptors,thereuptakeofDA,viadopaminetransporter(DAT),thediffusionofDAanditsmetabolismbymono-amineoxidase(MAO)andcatechol-O-methyltransferase(COMT).DAcontrolscomplexand

简介：Thepresentstudywasdesignedtodeterminemicrotubule-associatedprotein-2andsynaptophysinexpressioninthehippocampalCA3regioninaratmodelofmiddlecerebralarteryocclusion.TheratsweretreatedwithacupunctureatBaihui(GV20),Qubin(GB7),andQianding(GV21)points,inadditiontoexercisetraining.Resultswerecomparedwithratsundergoingexercisetrainingonly.TheY-mazemethodandimmunohistochemistryrevealeddecreasederrorfrequencyofpassingthroughY-maze,aswellassignificantlyincreasedmicrotubule-associatedprotein-2andsynaptophysinexpression,intheacupuncturewithexercisetraininggroupcomparedwiththemodelandexercisetraininggroupsafter5weeks.Microtubule-associatedprotein-2andsynaptophysinexpressionsnegativelycorrelatedwitherrorfrequencyofpassingthroughtheY-maze.Theseresultssuggestedthatacupuncturecombinedwithexercisetrainingimprovedlearningandmemoryfunctionsinaratmodelofcerebralinfarction.ThemechanismsofactionwerehypothesizedtobeassociatedwithdendriticorsynapticplasticityintheipsilateralhippocampalCA3region.