简介：Weappliedthediscreteelementmethod(DEM)ofsimulationmodifiedbyanenlargedparticlemodeltosimulatebeadmotioninalargebeadmill.Thestainless-steelbeadmillhasinnerdiameterof102mmandmilllengthof198mm.Thebeaddiameterandfillingratiowerefixedrespectivelyat0.5mmand85%.Theagitatorrotationalspeedwaschangedfrom1863to3261rpm.Thebeadmotionwasmonitoredexperimentallyusingahigh-speedvideocamerathroughatransparentmillbody.Forthesimulation,enlargedparticlesizesweresetas3-6mmindiameter.WiththeDEMmodifiedbytheenlargedparticlemodel,themotionofenlargedparticlesinamillwassimulated.Thevelocitydataofthesimulatedenlargedparticleswerecomparedwiththoseobtainedintheexperiment.ThesimulatedvelocityoftheenlargedparticlesdependsonthevirtualfrictionalcoefficientintheDEMmodel.Theoptimizedvalueofthevirtualfrictionalcoefficientcanbedeterminedbyconsideringtheaccumulatedmeanvalue.Resultsshowthatthevelocityoftheenlargedparticlessimulatedincreaseswithanincreaseintheoptimumvirtualfrictionalcoefficient,butthesimulatedvelocityagreeswellwiththatdeterminedexperimentallybyoptimizingthevirtualfrictionalcoefficientinthesimulation.Thecomputingtimeinthesimulationdecreaseswithincreasedparticlesize.

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简介：SiCwhiskerswith'rosarybead'morphologyweresynthesizedusingsuitablesiliconsourceandcarbonsourcethroughsolidreactionatthetemperatureabove1537K.ThediameterandlengthoftheSiCwhiskerswereabout0.1-1.0μmand20-100μm,respectively.Thelargestdiameteroftheirenlargedendsofthewhiskerswasabout0.2-1.0μm,anditgraduallyandsmoothlydecreasedtothesizeoftheplainpartofthewhiskers.TheresultsofX-raydiffractionanalysisshowthatthecrystallinestructureoftheobtainedSiCwhiskersisβ-SiC.ItisconsideredthattheSiCwhiskersgrowviaavapor-solidmechanism.

简介：Quantitativeresearchontheheataffectedzone(HAZ)ofweavebeadwelding(WBW)jointforInvaralloyiscarriedoutinthispaper.Basedonthemorphologyandrelateddataanalysisoftheweldseam,thewidthdifferenceofeachlayerandtheformingmechanismareanalyzed.Resultsshowthatthebottomlayer(Layer1)hasthewidestHAZandthesmallestfluctuation,whichreaches1200μm.HAZwidthoflayer2to5isrelativelynarrowerwhichisbasicallybelow600μm,whiletheamplitudefluctuationisgreater.Themainreasonliesintheweldingpath.Thelongstraightweldingwithoutweavecausesthebasemetalnearthegroovefullymeltswhichcausesbythelongstraightweldingwithoutweave,whileweldingwithweaveleadstotheunevenandinadequatemeltingofmetalneargroove.

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简介：OnthebasisOftheYoung-LaplaceEquationthatdescribesthepressuredifferencebetweeneachsideofacurvedliquidsurface,astaticequilibriummodelisestablishedtodescribethesurfaceshapeoftheweldbead.Thegeo-metricalmodelforthemoltenpoolisincluded,whichisessentialtoexplaintheundercutphenomenonduringhighspeedbead-on-platewelding.Theresultsgotfromaniterationalgorithmshowthatitistheforcebalanceontheliquidmixtureofthedepositedmetalandthedepositedmetalandthemoltenbasemetalandthemoltenbasemetalthatcausestheundercut.Somefactorsandtheireffectsarealsoana-lyzed.

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简介：载药洗脱微球结合了栓塞与局部化疗的优势,其经微导管注射,选择性对肿瘤供血动脉进行栓塞,使肿瘤缺血坏死;同时其向病灶部位持久缓慢地释放药物,形成局部高浓度,对肿瘤细胞产生显著的细胞毒效应。近年来载药DCBeadTM用于肝癌的栓塞化疗研究取得了较快的发展。本文就其制备方法、载药特点、体外释放方法、体内药动学及临床研究等方面进行了综述。

简介：为uveal黑瘤发现新biomarkers(嗯)由在病人分析浆液peptidomeprofile.METHODSProteomic系列与嗯在操作被分析前后并且与那些相比健康控制。磁性的亲密关系祷告被用来捕获浆液肽和帮助矩阵的激光解吸附作用/电离time-of-flight(MALDI-TOF)质量分光计被用来编49肽的浆液肽profiles.RESULTSA面板差别被表示在之间嗯病人和控制，哪个33肽具有在耐心的组的更高的紧张，16肽具有在控制的更高的紧张组。基于这些潜在的标记的联合使用，有1467和9289.0Da的吝啬的分子的群众的肽提供高敏感(83.3%)，特性(100%)和精确性率(93.0%)一起把黑瘤病人区分开来与健康控制。手术后地6mo指向时间，在外科前表示的许多肽差别的层次显示出病人和控制组之间的没有更多的统计差别。纤维蛋白原链先锋作为潜力被识别嗯markers.CONCLUSIONWe证明了一种方便、快的proteomic技术，亲密关系祷告分离和MALDI-TOF分析与生物信息的软件结合了，便于新奇biomarkers的鉴定为嗯。

简介：Flyashfloatingbead(FAFB)wasmodifiedbythenonionicsurfactantpolyethyleneglycol(PEG)undervariousconcentrationstoimproveitshydrophobility,andthenPEGmodifiedFAFBcompositedwithpolyaniline(FAFB-PEG/PAn)byemulsionpolymerizationmethodusingdifferentfeedratiosofFAFBPEG.Thechemicalstructure,phasestructure,microstructure,conductivity,anddielectricpropertieswerestudiedbyFT-IR,XRD,SEM,four-probetechnique,andLCRdigitalbridge,respectively.ItwasdemonstratedthattheoptimalconcentrationofPEGwas1mol/Landthecorrespondinggraftingratiowas1.42%.ThephasestructureofFAFBwasnotdestroyedaftermodificationbyPEG,whilethesurfacebecamesmootherandcouldbecoatedbyPAnsuccessfullyaccordingtoSEMtechnique.ComparedtothatofdodecylbenzenesulfonicaciddopedPAn(PAn-DBSA),theconductivityofFAFB-PEG/PAnwasdecreasedby10-100timesafterintroductionofvariousamountsofFAFB-PEG,especiallythevaluecouldbedecreasedto0.01Scm~(-1)if50wt%ofFAFBPEGwasprovided.Additionally,thedielectricconstantandlossfactorofFAFB-PEG/PAncompositesgraduallydecreasedwithincreasingamountofFAFB-PEGinthefrequencyrangeof100KHz-2MHz,namely,thedielectricconstantcouldbestillkeptat500andcorrespondinglythelossfactordecreasedto4.7at100KHzif50wt%ofFAFB-PEGwasprovided.TheleakingcurrentphenomenonderivedfromPAn-DBSAcouldalsobeweakenedbyFAFB-PEG.

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简介：Theout-of-planedeformationisaseriousprobleminthin-plateweldedjoint,anditisdifficulttoreduceorcontrolthedistortionduringweldingprocess.Externalrestraintisregardedasaneffectivemethodtomitigatethedistortion,anditiswidelyusedintheactualmanufacturingprocess.Inordertoinvestigatetheinfluenceofexternalrestraintonweldingdeformationinthinplatejoints,athermo-elastic-plasticfiniteelementmethodbasedonABAQUSsoftwarewasdevelopedtocalculatewelding-induceddeformation.Meanwhile,weldingdeformationinthethin-platejointswasmeasuredbyexperiments.Throughcomparingthenumericalresultswiththemeasureddata,theeffectivenessofthedevelopedcomputationalapproachwasverified.Basedonthesimulatedandexperimentalresults,thegenerationmechanismoftheout-of-planedeformationinthinplatebead-onjointwasdiscussed,andtheinfluenceofexternalrestraintonthefinalweldingdeformationwasclarified.

简介：1.6公里厚的表的非合金的钛的变硬的激光转变(LTH)，更近，到ASTM，等级3化学作文用2kWCWNd被调查:钇铝柘榴石激光。激光力量的效果(750-1250W)，扫描速度(10003000mm/min)和焦点的点位置(从?10到?30公里)在热输入，和变硬祷告的几何学上(即变硬的祷告宽度(HBW)，变硬的深度(HD)和变硬的祷告的入口的角度与表面(AEHB)介绍)用反应表面方法论(RSM)被调查。试验性的计划基于Box-Behnken设计矩阵方法。为预言热输入和变硬的祷告几何学的线性、二次的多项式方程被开发。结果显示建议模型在变硬的参数的限制以内足够地预言回答被使用。回归方程能被用来为需要的标准发现最佳变硬条件，这被建议。

简介：one-bead-one-compound(OBOC)组合的肽图书馆是一个强大的工具识别ligand和受体相互作用。这里，我们使用了OBOC图书馆技术识别对主要贝壳变应原tropomyosin的免疫球蛋白E(IgE)epitopes特定的mimotopes。有8-12氨基酸残余的OBOC肽图书馆为tropomyosin的IgEmimotopes与贝壳过敏症从病人与浆液样品被屏蔽。25mimotopes从屏蔽被识别，他们到tropomyosin特定的IgE的有约束力的反应被肽ELISA证实。这些mimotopes能基于顺序相同被划分成七簇，并且由聚类的mimotopes的EpiSearch印射的epitope被执行描绘并且证实mimotopes的有效性。五从六预言的epitopes被发现与tropomyosin的以前识别的epitopes重叠。为了推进，证实mimotopes的模仿潜力，BALB/c老鼠被使免疫，mimotopes结合了到锁眼恋栈者hemocyanin和assayed让他们的能力导致tropomyosin特定的抗体。那收到的mimotope免疫被发现有tropomyosin特定的免疫球蛋白G的提高的水平的BALB/c老鼠，然而并非收到了无关的mimotope的老鼠。这研究用整个sera开创OBOC图书馆的成功的申请屏蔽并且识别多重虾变应原mimotopes并且验证他们在vitro使用的模仿潜力，在vivo，并且在silico方法。

简介：TheHAZmicrostructureandperformanceofQuenchingandTemperingmodetemperbeadweldingandgeneralweldedjointswhichweremadeonSA508-3steelof60mmthicknesswerecomparedinthisarticle.Theresultshowsthattemperingsorbitewhichhasexcellentoverallperformancewasobtainedinbothmodes.ThemicrostructureofQuenchingandTemperingmodeweldedjointsgotmorefinegrain.Eventhoughthehardnessoftemperingbeadweldedjointsishigherthanthegeneralone,itstillmeetsthestandardswhichislowerthan350HV.TheimpactabsorbingenergyofeachdistrictoftemperingbeadweldedjointsHAZreached170J,whichisequaltogeneralone.

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