简介：ICR-PS1000M采用了雅玛哈高质量音频技术。PCM录音最高对应16bit／48kHz，MP3录音最高对应320kbps，而且特别针对录制乐器声音而开发了“VAS机能”，可以在乐器停止播放时自动停止录音，一旦声音重起再自动开启录音，非常智能、人性化。

简介：目的研究生孢梭菌代谢产物对ICR小鼠的毒性作用。方法将分离自浓缩乳清蛋白粉及其制品样品中的生孢梭菌分别培养在庖肉肉汤及TPGY肉汤培养基中,将过滤除菌及处理后的培养液分别经灌胃和腹腔注射给予ICR小鼠,观察其中毒及死亡情况。结果生孢梭菌培养液及处理后的培养液经腹腔注射ICR小鼠后均对其有毒性作用,中毒症状表现为小鼠急促呼吸后猝死,死亡时间多集中在10min内,平均为5~7min,A-F多价抗肉毒毒素诊断血清对小鼠无保护作用。结论生孢梭菌代谢产物中含有不同于肉毒毒素的有毒代谢产物,腹腔注射可导致ICR小鼠猝死。

简介：AbstractObjective:Despite the fact that adenomyosis is a fairly common gynecological disorder, its pathogenesis remains elusive. Several theories on the pathogenesis of adenomyosis have been proposed, but none of them has been proven experimentally. So far, the most used one is the neonatal feeding of tamoxifen (TAM) in Institute of Cancer Research/cryopreserved (ICR/CD-1) mouse. However, its underlying mechanism of action is unknown. To further delineate the mechanism of TAM-induced adenomyosis in ICR/CD-1 mouse with regard to specific estrogen receptor (ER), we conducted an experiment that neonatal mice were fed with either TAM, or 4,4′,4″-(4-propyl-[1H]-pyrazole-1,3,5-triyl) trisphenol (PPT; an ERα agonist), or 2,3-bis(4-hydroxyphenyl)-propionitrile (DPN; an ERβ agonist), or G-1 (a G-protein coupled receptor 30 agonist), or just vehicle, in an attempt to tease out which specific receptor plays a dominant role in the genesis of adenomyosis induced by neonatal feeding of TAM.Methods:Forty female neonatal mice were randomly divided into 5 equal-sized groups: CTL (control), TAM, PPT, DPN, and G-1. Three months later, all mice were sacrificed and their uterine horns were harvested, weighed, and processed for histological evaluation.Results:All mice in the TAM group developed adenomyosis, so did 4 mice (50%) in the DPN group, a result that should be considered significant given that mice in the CTL group would not develop adenomyosis. No mouse in the PPT or G-1 group developed adenomyosis. Remarkably, all lesions in the DPN group were seen exclusively near the uterine serosa, which are dramatically different from that of TAM mice and reminiscent of extrinsic or external adenomyosis in humans.Conclusions:Neonatal feeding of DPN induces adenomyosis, but the adenomyotic lesions appear to be different from those induced by TAM. Thus, the cause of TAM-induced adenomyosis in ICR/CD-1 mouse cannot be attributable to one specific ER alone. This suggests that the extrinsic/external adenomyosis may have a pathogenesis that is different from other sub-types of adenomyosis.

简介：目的建立茄病镰刀菌感染皮肤的ICR小鼠模型。方法将茄病镰刀菌三个不同浓度的菌悬液分别接种于正常和免疫抑制ICR小鼠受损及正常未受损的皮肤，于接种后第7、14、21、28天处死动物，取皮疹和各脏器进行真菌镜检、培养和组织病理学检查。结果正常和免疫抑制组皮肤受损的小鼠均出现皮疹，而免疫抑制组皮疹程度重，持续时间长，且真菌镜检、培养及组织病理学大都可见菌丝。皮肤未受损的小鼠不发生皮疹。实验小鼠均未出现系统播散。结论接种10^9CFU／mL或10^10CFU／mL茄病镰刀菌的孢子悬液于免疫抑制ICR小鼠擦伤的皮肤，可有效造成ICR小鼠的茄病镰刀菌皮肤感染。

简介：目的：建立一种简单的高效分离、培养、纯化和鉴定ICR小鼠骨髓间充质干细胞（bonemarrow-derivedmesenchymalstemcells,BMSCs）的方法,初步研究其相关生物学特性。方法：全骨髓贴壁法分离培养BMSCs,用倒置显微镜观察细胞的形态和生长情况;用流式细胞仪鉴定细胞表面标记物;诱导细胞定向分化为成脂细胞、成骨细胞,以检测细胞多向诱导分化能力。结果：利用该方法纯化的BMSCs形态均一,多为梭形。第3代BMSCs进行流式检测CD29、CD44均呈阳性表达,表达率分别为97%、90%;CD34、CD45呈阴性表达;且能够成功诱导分化成成骨细胞、成脂细胞。结论：利用全骨髓贴壁法可以高效分离、纯化ICR小鼠的BMSCs,生物学特性稳定。

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简介：摘要目的建立SD大鼠和ICR小鼠常用血液学及血清生化指标正常值参考范围，并比较不同性别，周龄，及供应商动物结果之间的差异。方法血液常规分析使用迈瑞BC5300-vet动物专用五分类全自动血液细胞分析仪，血清生化使用迈瑞BS-380全自动生化分析仪。使用SPSS17.0统计学软件对检测结果进行t检验。结果获得4~5周龄和8~9周龄不同性别和供应商SD大鼠和ICR小鼠血液学和血清生化平均值及正常参考范围；应用SPSS软件T检验分析表明性别、周龄及供应商不同时，同一品系动物的部分血液学和血清生化结果有显著性差异。结论在动物实验中，对血液学和血清学检测结果进行评价时应考虑不同性别、周龄及来源对数据的影响。

简介：摘要目的通过本试验观察供试品注射用右旋兰索拉唑对ICR小鼠神经系统的影响，为临床研究和用药安全提供参考。方法静脉注射给予ICR小鼠注射用右旋兰索拉唑（5、15和45mg/kg），并与消旋体对照品注射用兰索拉唑（45mg/kg）比较，观察小鼠的行为表现和自发活动。结果ICR小鼠静脉注射给予供试品及注射用兰索拉唑后，行为表现等均未见异常；注射25mg/kg戊巴比妥钠后睡眠发生率明显提高，入睡时间长度显著缩短，睡眠时间长度显著延长；在各时间点ICR小鼠自发活动数无明显差异。结论在本试验条件下，注射用右旋兰索拉唑及注射用兰索拉唑对ICR小鼠的行为表现和自发活动无明显影响；与镇静催眠药物戊巴比妥钠同时使用具有明显的协同作用。

简介：摘要：机动性能对于轮式移动机器人的应用往往具有关键意义，但现有的移动机器人机动性量化方法较为粗略。本文面向常见的(1,1)类轮式机器人的机动性，指出机动性与瞬时旋转中心的分布范围、瞬时旋转中心位置切换快慢的能力、瞬时旋转中心位置切换的连续性以及最小转弯半径均相关。本文分析了上述机动性影响因素与（1,1）类三种机器人结构参数间的关系。 关键词：轮式移动机器人、机动性、瞬时旋转中心

简介：ThemoleculartransformationsofcarboxylicacidsinheavyacidicSLcrudebeforeandaftertrueboilingpointdistillationwereexaminedbyultra-highresolutionnegative-ionelectrosprayionization(ESI)Fouriertransformioncyclotronresonancemassspectrometry(FT-ICRMS).Theacidclass(heteroatomnumber),type(znumbers)andcarbonnumberdistributionswerepositivelycharacterized.Itwasfoundoutthatthetotalacidnumber(TAN)ofSLcrudedecreasedaftertrueboilingpointdistillation,andtheabundanceofO2classinmassspectrawasalsofoundtobereducedfrom67.6%to34.5%inSLTBPmixedcrudeasmeasuredbyMSspectra,indicatingtoapotentialcarboxylicaciddecomposition.However,itwasinterestingthatthecarboxylicacidstypedistributioninbothoilswasalmostthesamealthoughtheirrelativeabundanceinSLTBPmixedcrudeturnedtobemuchlower,suggestingthatvariouspetroleumcarboxylicacidtypeshavethesimilarthermaldecompositionreactionbehavior.Furthermore,foreachO2typeofacidsinSLTBPmixedcrude,theabundanceofcarboxylicacidswithcarbonnumberhigherthan35wasreducedgreatly,especiallyforthosewithcarbonnumberhigherthan60,themasspeaksofwhichwerenearlytotallyremoved,indicatingthatthelargecarboxylicacidmoleculesinheavyfractionsdecomposedmoresignificantlybecauseoflongerheatingtimeduringthetrueboilingpointdistillationprocess.Asaresult,thereductionofTANmaybecausedbythethermaldecompositionofcarboxylicacidsespeciallythosewithhighcarbonnumber,suggestingthatquickdistillationormuchlowerpressureisrequiredtoavoidthethermaldecomposition.

简介：目的探讨C57BL/6与ICR小鼠在博来霉素（BLM）致肺纤维化过程中的种属差异。方法8周龄雌性C57BL/6小鼠19只,ICR小鼠16只,分别经尾静脉一次性注射BLM150mg/kg,观察每组小鼠体重、生存率及肺组织病理改变。结果①C57BL/6与ICR小鼠最低体重分别发生在静脉注射处置后的7d和5d,最低体重分别为注射前的65.46%和73.21%,两组间无显著的统计学差异。②C57BL/6与ICR小鼠的生存率分别为36.84%和56.25%,两组间存在显著的统计学差异。③C57BL/6小鼠BLM注射后28d,在胸膜下及血管周围形成广泛、稳定的间质纤维化病理改变,而ICR小鼠肺组织未见明显纤维化形成。C57BL/6小鼠肺纤维化病理评分明显高于ICR小鼠（P〈0.001）。结论BLM诱导的肺纤维化作用在C57BL/6与ICR小鼠间存在着明显的种属差异。C57BL/6小鼠较ICR小鼠更适于复制博来霉素诱导的肺纤维化动物模型。

简介：HighresolutionmassspectrometryincombinationwithdistillationandSARAfractionationprovidesusanopportunityforin-depthunderstandingaboutthehydrotreatingprocessatthemolecularlevel.Inthisstudy,theatmosphericresiduederivedfromArabianheavycrudeanditshydrotreatedproductswereinitiallysubjectedtodistillationandSARAfractionation.ThesaturateswerecharacterizedbyGCFI/FDTOFMS.ThearomaticsandresinswerecharacterizedbyAPPIFT-ICRMS.Compositionalchangesofdifferentcompounds(paraffins,naphthenes,aromatichydrocarbons,andheteroatomiccompounds)containedindifferentdistillates(vacuumgasoil,vacuumresidue)wereobtained.Moredetailedknowledgeaboutthehydrotreatingprocesswasachieved.