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简介：AbstractBackground:Leukocyte telomere length shortening is a characteristic of premature senescence, a process that can be accelerated by oxidative stress. In general, patients with end-stage renal disease undergoing regular hemodialysis (HD) are repeatedly exposed to oxidative stress. Patients undergoing HD tend to have cardiovascular diseases associated with oxidative stress and inflammation. Therefore, we assumed that telomere length is associated with HD vintage and the degree of vascular calcification.Methods:A total of 144 patients undergoing regular HD before kidney transplantation and 62 patients on hemodialysis, but not undergoing kidney transplantation, were enrolled. We measured common laboratory values, such as calcium, phosphate, and hemoglobin levels, and assessed the degree of vascular calcification in the patients. The leukocyte telomere length was measured using reverse transcription polymerase chain reaction, and Spearman correlation was used for correlation analysis.Results:The leukocyte telomere length was negatively associated with age (rho = -0.306, P <0.01); it was shorter in middle-aged patients than in young patients (13.48 ± 4.80 vs. 15.86 ± 4.51, P < 0.01). The telomere length was significantly different among patients aged 52-74 years in groups with different HD vintages. Additionally, the telomere length was positively associated with serum hemoglobin (Hb) levels in all patients (rho = 0.290, P < 0.01). There was a significant difference among patients divided into three groups according to the degree of anemia (17.09 ± 5.64 vs. 14.40 ± 4.07 vs. 13.99 ± 3.95, P < 0.01). Further, a significant difference was observed in the telomere length among patients with different degrees of vascular calcification (16.79 ± 4.91 vs. 13.61 ± 2.82 vs. 14.62 ± 3.63 vs. 10.71 ± 3.74, P < 0.01). The telomere length was shorter in the patients on hemodialysis who did not receive a kidney transplant than in the surgical patients (8.12 ± 1.83 vs. 14.33 ± 4.63, P < 0.01).Conclusion:This study demonstrated that the telomere length was significantly correlated with HD vintage in patients of a certain age group. The telomere length was shorter in patients on hemodialysis who matched for age and dialysis vintage with kidney transplant patients. It was also associated with vascular calcification and serum Hb levels in all patients undergoing HD.

简介：识别北半球(NH)温度重建和仪器的数据过去的1000年证明气候在最后千年includeslong术语趋势和各种各样的摆动变化。二个长期的趋势和quasi-70-year摆动在全球温度系列被检测最后140年和NH千年系列。一个重要特征被强调那温度慢慢地减少，但是它基于不同系列的分析很快增加。好处能从理解各种各样的长期的趋势和摆动气候变化被获得。从自然气候系统和非线性的模型系统的时间序列的千年的温度代理在理解自然气候变化并且认识到由使用小浪的方法的潜在的好处转变分析被使用。从主要摆动在数值解释包含了在上的数字当模特儿的表演的结果内部十的时间规模与自然代理的一致。看起来，在气候变化的这些摆动直接没作为外部强迫与太阳辐射被连接。这调查可以断定在interdecadaltimescale的气候可变性强烈在气候系统取决于内部非线性的效果。

简介：作为常规授精的一种选择评估器官的修正案的使用，沃土土壤的一个10年的实验在在Guadalquivir河山谷与化肥(NPK)和植物的堆肥(器官的化肥)使用的温室和室外的阴谋在一个庄稼旋转系统下面被进行，西班牙。土壤上的这二不同授精政体的效果物理性质被评估。玷污器官的碳(OC)，土壤体积密度(BD)，土壤水保留(WR)，可得到的水内容(AWC)，总数稳定性(作为)，并且玷污物理质量(德克斯特的索引，S)被决定。器官的化肥的使用增加了OC并且导致了的重要增加作为并且在与在温室和室外的阴谋的矿物质化肥申请相比的BD的减少。而温室阴谋出现了，室外的阴谋显示出最低BD价值象价值最高。在10年的实验的最后年里，S参数在器官的化肥阴谋是显著地更高的，特别为温室阴谋。在学习经期的结束，在在在在两个系统的治疗之间的领域能力(FC)的WR没有重要差别；AWC在矿物质在温室阴谋，但是更高也是类似的室外的阴谋。在矿物质化肥处理，在物理性质的小改进也与以前的集中的收割系统相比由于不太好攻击的耕种的利用被观察。物理土壤性质与土壤OC被相关。持续管理技术象器官的修正案的使用那样并且低或没有耕种改进了土壤物理性质，尽管有在管理的差别，那显著地逻辑地影响了结果。

简介：ThreekindofapplicationofADCPisreportedforlong-termmonitoringincoastalsea.(1)Therourinemonitoringofwaterqualities.ThewaterqualityandADCPechodata(600kHz)observedinthelong-termareanalgzedatMT(MarineTower)StationofKansaiInternationalAirportintheOsakaBay,Japan.Thecorrelationbetweentheturbidityandechointensityinthesurfacelayerisnotgoodbecauseairbubblesgeneratedbybreakingwavearenotdetectedbytheturbiditymeter,butdetectedwellbyADCP.Whenestimatingtheturbidityconsistsofplanktonpopulationfromechointensity,theeffectofbubbleshavetobeeliminated.(2)Monitoringstirringupofbottomsediment.ThespecialobservationwascardedoutbyusingfollowingtwoADCPintheOsakaBay,OneADCPwasinstalledupwardonthesea.TheotherADCPwashangeddownwardatthegatetypestandabout3mabovefromthebottom.Atthespringtide,highechointensitiesindicatingthestirringupofbottomsedimentwereobserved.(3)Themonitoringfortheboundaryconditionofwatermixingatanestuary.Insummerseason,theADCPwassetatthemouthofTanabeBayinWakayamaPrefecture,Japan.Duringtheobservation,watertemperaturenearthebottomshowedremarkablefallswithintervalofabout5～7d.Whenthebottomtemperaturefell,theinflowcurrentwithlowechointensitywaterappearsatthebottomlayerintheADCPrecord.Itisconcludedthatwhenoccasionalweaknortheastwindmakesweakcoastalupwellingatthemouthofthebay,thecombinationofupwellingwithinternaltidalflowcausesremarkablewaterexchangeanddispelstheredtide.

简介：AgroupofCanadianphysiciansreportssuccessinthelong-termcontroloftreatment-resistantdepressionbyusingdeepbrainstimulation,buttheyacknowledgethatlongerandlargertrialsarestillneeded.

简介：Objective:Toobservethelong-termeffectofhomoharringtonine(HHT)onchronicgranulocyticleukemia(CGL)anditspharmacologicalmechanism.Methods:76patientswithnewlydiagnosedearlychronicphaseCGLreceivedtreatmentofmerely1.5mg/m2dailyHHTforinductionremissionandlong-termmaintenancetreatment.TheapoptosisrateofbonemarrowCD34+cellsinducedbyHHTwasassayedwithflowcytometer.Results:86.8%patientsachievedCHR,13.2%patientsPHRand31.8%patientsgotcytogeneticresponseinHHTtreatmentgroup,whichwaslongerthan31(8-54)monthsinhydroxyurea(HU)group(P<0.05).TheeffectofapoptosisinductionHHTwasstrongeronCGL-CPpatientsbonemarrowCD34+cellsthanonnormalpersonbonemarrowCD34+cells.Conclusion:HHTisaveryeffectivedrugforremissioninductionandlong-termmaintenancetreatmentinearlychronicphaseCGLpatients.

简介：Thisarticleexplorespopulationlong-termbalanceddevelopmentfornationaldefenseaccordingtothestrategicgoalssetatthe18thNationalCongressoftheCommunistPartyofChina.Threemajorissuesarediscussed.Firstly,theconceptandconnotationofthelong-termequilibriumdevelopmentofnationaldefensepopulationaredefined,inwhichpopulationlong-termequilibriumisequaltopopulation'longtermsafety'includingqualitybalance,quantitybalanceandpopulationstructureequilibrium.And'quantityequilibrium'needstobeconsideredinbothabsoluteandrelativeterms.Secondly,the'non-equilibrium'situationofnationaldefensepopulationisexaminedfromtheperspectiveofqualityandquantity.Thirdly,policysuggestionsinpromotingthenationaldefensepopulationequilibriumareproposedwithregardtopopulationregulation,humanresourcedevelopmentandsocialsecurity.

简介：TheNorthChinaPlain(NCP)isthemostimportantfoodgrainproducingareainChinaandhassufferedfromseriouswatershortages.Tocapturevariationwateravailability,itisnecessarytohaveananalysisofchangingtrendsinprecipitation.Thisstudy,basedondailyprecipitationdatafrom47representativestationsinNCPrecordspassedthehomogeneitytest,analyzedthetrendandamplitudeofvariationinmonthly,seasonalandannualprecipitation,annualmaximumcontinuousno-raindays,annualraindays,rainfallintensity,andrainfallextremesfrom1960to2007,usingtheMannKendall(M-K)testandSen’sslopeestimator.Itwasfoundthatmonthlyprecipitationinwinterhadasignificantincreasingtrendinmostparts,whilemonthlyprecipitationinJulytoSeptembershowedadecreasingtrendinsomepartsofNCP.Nosignificantchangingtrendwasfoundfortheannual,dryandwetseasonprecipitationandrainfallextremesinthemajorityofNCP.Asignificantdecreasingtrendwasdetectedforthemaximumno-raindurationandannualraindaysinthemajorpartofNCP.ItwasconcludedthatthechangingtrendofprecipitationinNCPhadanapparentseasonalandregionalpattern,i.e.,precipitationshowedanobviousincreasingtrendinwinter,butadecreasingtrendintherainyseason(JulytoSeptember),andthechangingtrendwasmoreapparentinthenorthernpartthaninthesouthernandmiddleparts.Thisimpliesthatwithglobalwarming,seasonalvariationofprecipitationinNCPtendstodeclinewithanincreasingofprecipitationinwinterseason,andadecreasinginrainyseason,particularlyinthesub-humidnorthernpart.

简介：AbstractObjective:To compare the efficacy of the traditional Chinese medicine SanJieZhenTong (SJZT) capsules versus gonadotropin-releasing hormone analogs (GnRHa) or oral contraceptives (OCs) in the postoperative treatment of moderate-to-severe endometriosis.Methods:In this prospective clinical trial, women with stage III-IV endometriosis according to the revised American Fertility Society scoring system received three doses of GnRHa immediately after laparoscopic conservative surgery, followed by random assignment to receive treatment with SJZT, GnRHa, or OCs for another 6 months. The primary endpoint was 2-year recurrence, and the secondary endpoints were adverse events, changes in physical function, and quality of life (QoL). Recurrence was assessed using Kaplan-Meier curves and log-rank tests. Generalized estimating equations were used to determine the parameters of the secondary endpoints.Results:A total of 66 women were randomly assigned to the SJZT (n = 21), GnRHa (n = 21), and OCs (n = 24) groups. At a median follow-up of 22 months, no difference in recurrence was found (P = 0.72), with one (4.8%), two (9.5%), and one (4.2%) incidence in the SJZT, GnRHa, and OCs groups, respectively. Expectedly, the incidence of side effects such as hot flush, insomnia, and arthralgia in the SJZT and OCs groups was significantly lower than that in the GnRHa group (P = 0.00). In addition, the female sexual function index was significantly improved in the SJZT group, with a higher value than that in the GnRHa (odds ratio [OR] = 5.25, 95% confidence interval [CI]: 2.09-13.14, P = 0.00) and OCs (OR = 3.94, 95% CI: 1.58-9.83, P = 0.00) groups.Conclusions:SJZT showed more effective pain relief and QoL improvement in patients with moderate-to-severe endometriosis than GnRHa or OCs did. Fewer adverse events than those observed with other agents indicate that this alternative medicine, SJZT, could be a novel option for the long-term management of endometriosis.

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简介：Objective:Toinvestigatetheprevalenceoflong-termfatigue,anxiety,depressionandsocialsupport,andtherelationshipsamongthesesymptomsinpostoperativepatientswithbreastcancer.Methods:Atotalof180postoperativepatientswithbreastcancermeetingcriterionwererecruitedinthiscross-sectionalstudy.TheBriefFatigueInventory(BFI),HospitalAnxietyandDepressionScale(HADS)andTheSocialSupportSurvey-Chineseversionwereusedtoassessingthefatigue,anxietyanddepression,Socialsupportofparticipants.ThemagnitudeoftherelationshipamongthesymptomsoffatigueandothervariableswasmeasuredbySpearmanRhocorrelation.Results:Theprevalenceoflong-termfatiguewas52.7%,and18.3%occurredmoderate/severefatigue.Two-thirdsofpatientshadabasalsocialsupport,only12.8%ofpatientshadbetter-perceivedsocialsupport.ResultsofHADSshowedthat16.7%and21.1%oftheparticipantshaveanxietyordepressiondisorder.Moderate/severefatiguewasnegativelycorrelatedwithsocialsupport(r=–0.158,P=0.038)andpositivelycorrelatedwithage(r=0.132,P=0.042),chemotherapy(r=0.297,P=0.027),anxiety(r=0.324,P=0.018)anddepression(r=0.211,P=0.034).Conclusions:Long-termfatiguewashighlyprevalentamongoverhalfofpostoperativepatientswithbreastcancer,andmoderate/severefatiguewasassociatedwithsocialandpsychologicalfactorssuchassocialsupport,anxietyanddepression.Ourresultssuggestthatoverallnursingcaremaybeamoreeffectivemannerinimprovingfatigueandqualityoflife.

简介：BackgroundArrhythmogenicrightventricularcardiomyopathy(ARVC)isamajorcauseforsuddencardiacdeathduetoventriculartachycardia.Litterisknownaboutitslong-termoutcomesinChineseARVCpatients.Thepurposeofthisstudywastoevaluatethelong-termclinicaloutcomesinpatientswithARVCandtoclarifytheriskfactorsofcardiacevents.MethodsFortysubjectsfulfillingmodifiedTaskForcecriteriawereincludedinthisstudy.Informationonclinicalpresentation,electrocardiographicandcardiacimagingfindings,andlong-termoutcomeofcaseswereinvestigated.ResultsAveragefollow-upperiodfromonsetwas57.5±42.6months.Themeanageatonsetofsymptoms(32.2±12.7years)andmalepredominance(85.0%)weresimilartothatreportedinotherstudies.Palpitationswerethemostfrequentsymptom(82.5%).T-waveinversionwasthemostcommonpresentingabnormalityonresting12-leadECG(75%).Ventriculartachycardiawithleftbundlebranchblockmorphologywassubsequentlydocumentedinatotalof28(70%)subjectsduringastudyperiod.Thecumulativemortalityratewas7.5%.ConclusionClinicalpresentationinChineseARVCpatientswassimilartothatreportedinotherstudies.ARVCisassociatedwithearlymortalitythatisdifferenttoothercountrypopulation.

简介：Biogenicstabilizationprocessesthatresultintheformationofbiofilmsandinterparticle-networkscansignificantlyalterthetransportcharacteristicsoffinegrainedsedimentlayers.Theincreaseinthethresholdofsedimentmotioncanamounttouptoseveralhundredpercent.Whileplancticorganismsareinvolvedintheformationofdepositingflocsandtheearlystagesofconsolidation,thesecondaryconsolidationiscontrolledbymicrobialbreakdownprocesses,leadingtochangesinthemechanicalpropertiesofcohesivesediments.Whiletheprimarystageofconsolidationiscompletedindays,thesecondaryprocessescanlastfordecades.Apreliminaryseriesoferosiontestsinanannularflumerevealeddemonstratedthebiogenicimpactintheearlystagesofsedimentformation.Surrogatematerialswereusedtosimulatethegoverningpropertiesofnaturalsoftsediments.

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简介：LongtimebehaviorofdegenerateequationswiththenonlinearityofpolynomialgrowthofarbitraryorderonthewholespaceRNisconsidered.Byusing-trajectoriesmethods,weprovedthatweaksolutionsgeneratedbydegenerateequationspossessan(L2U(RN),L2loc(RN))-globalattractor.Moreover,theupperboundsoftheKolmogorovε-entropyforsuchglobalattractorarealsoobtained.

简介：前列腺癌症预防选拔赛(PCPT)是泌尿学的领域里的精液的研究。在它的起始的出版以后的超过10年，从这试用的更新的数据继续塑造我们前列腺癌症的理解。一旦想了在正常范围，在从PCPT的主要调查结果之中是前列腺癌症在有前列腺特定的抗原(PSA)的人是普通的示范，1finasteride阻止良性的prostatic肥大的发展，2它而且增加PSA3和数字直肠的examination.4的敏感PCPT帮助建立在可勃起的机能障碍和心血管的疾病之间的连接，5并且也许，最重要地，finasteride表明了25%相对风险reduc