简介：Objective:ToevaluatetheefficacyandsafetyofintratympanicandsystemicsteroidtherapiesintheinitialtreatmentofSuddenSensorineuralHearingLoss(SSNHL)patients.Methods:AcomprehensivesearchofPubMed,WanfangdatabaseandCNKI(ChinaNationalKnowledgeInfrastructure)wasperformedcoveringtheperiodfromJanuary1990toJuly2014.Ameta-analysiswasconductedafterfilteringbythecriteriaofCochraneCollaboration.Threehundredfiftysixsubjectsinninestudiesallocatedtothegroupofintratympanicsteroidtherapiesand343controlsreceivingsystemicsteroidtherapiesmetthecriteriaformeta-analysis.ThedatawereextractedandanalyzedusingtheRevMan5.3meta-analysissoftware.Results:ThetotaleffectivenessrateinSSNHLpatientsreceivingintratympanicsteroidtherapiesdidnotdifferstatisticallyfrompatientsreceivingsystemictherapies(RR=1.08,95%CI=0.99-1.99,P=0.10),althoughtherateoffullhearingrecoveryinthisgroupdifferedsignificantlyfrompatientsreceivingsystemictherapies(RR=1.29,95%CI=1.00-1.66,P=0.05).Conclusion:LocalsteroidtherapyappearstogeneratehigherrateofcompletehearingrecoverythansystemicsteroidtreatmentasaninitialtreatmentforSSNHL,whichmaybeespeciallyusefulforpatientsinwhomsystemicsteroidsarecontraindicated.

简介：摘要目的系统评价鼠神经生长因子联合康复训练改善脑卒中患者预后的疗效观察。方法检索公开发表的鼠神经生长因子联合康复训练改善脑卒中患者预后疗效的相关文献，提取有关临床效果指标进行Meta分析。结果共计260例脑卒中患者预后运动功能改善的合并检验分析Z=5.53（P＜0.00001），OR值=9.12,95%可信区间为5.89~12.35，日常生活能力改善的合并检验分析Z=7.02（P＜0.00001），OR值=9.83,95%可信区间为7.09~12.58。结论鼠神经生长因子联合康复训练对脑卒中患者预后的运动功能及日常生活能力有明显改善。