简介:Proteomicsisthestudyofproteinsandtheirinteractionsinacell.WiththecompletionoftheHumanGenomeProject,theemphasisisshiftingtotheproteincomplimentofthehumanorganism.Becauseproteomereflectsmoreaccuratelyonthedynamicstateofacell,tissue,ororganism,muchisexpectedfromproteomicstoyieldbetterdiseasemarkersfordiagnosisandtherapymonitoring.Theadventofproteomicstechnologiesforglobaldetectionandquantitationofproteinscreatesnewopportunitiesandchallengesforthoseseekingtogaingreaterunderstandingofdiseases.High-throughputproteomicstechnologiescombiningwithadvancedbioinformaticsareextensivelyusedtoidentifymolecularsignaturesofdiseasesbasedonproteinpathwaysandsignalingcascades.Massspectrometryplaysavitalroleinproteomicsandhasbecomeanindispensabletoolformolecularandcellularbiology.Whilethepotentialisgreat,manychallengesandissuesremaintobesolved,suchasmininglowabundantproteinsandintegrationofproteomicswithgenomicsandmetabolomicsdata.Nevertheless,proteomicsisthefoundationforconstructingandextractingusefulknowledgetobiomedicalresearch.Inthisreview,asnapshotofcontemporaryissuesinproteomicstechnologiesisdiscussed.
简介:Source:MITTechnologyntroductionNotallbreakthroughsarecreatedequal.Somearrivemoreorlessasusablethings;othersmainlysetthestageforinnovationsthatemergelater,andwehavetoestimatewhenthatwillbe.Butwe’dbetthateveryoneofthemilestonesonthislistwillbeworthfollowinginthecomingyears.1.MagicLeap
简介:Biometricstechnologieshavebeenaroundforquitesometimeandmanyhavebeendeployedfordifferentapplicationsallaroundtheworld,rangingfromsmallcompanies’timeandattendancesystemstoaccesscontrolsystemsfornuclearfacilities.Biometricsofferareliablesolutionfortheestablishmentofthedistinctivenessofidentitybasedon"whoanindividualis",ratherthanwhatheorsheknowsorcarries.BiometricSystemsautomaticallyverifyaperson’sidentitybasedonhis/heranatomicalandbehavioralcharacteristics.Biometrictraitsrepresentastrongandundeviatinglinkbetweenapersonandhis/heridentity,thesetraitscannotbeeasilylostorforgottenorfaked,sincebiometricsystemsrequiretheusertobepresentatthetimeofauthentication.Somebiometricsystemsaremorereliablethanothers,yettheyareneithersecurenoraccurate,allbiometricshavetheirstrengthsandweaknesses.Althoughsomeofthesesystemshaveshownreliabilityandsolidarity,workstillhastobedonetoimprovethequalityofservicetheyprovide.Presentedistheavailablestandingbiometricsystemsshowingtheirstrengthsandweaknessesandalsoemergingtechnologieswhichmayhavegreatbenefitsforsecurityapplicationsinthenearfuture.
简介:The18monthssinceCHEP'2000haveseensignificantadvancesinGridcomputing,bothwithinandoutsidehighenergyphysics,Whileinearly2000,GridComputingwasanovelconceptthatmostCHEPattendeeswerebeingexposedtoforthefirsttime,wenowseeconsiderableconsensusonGridarchitecture,asolidandwidelyadopetedtechnologybase,majorfundinginitiatives,awidevarietyofprojectsdevelopingapplicationsandtechnologies,andmajordeploymentprojectsaimedatcreatingrobustGridinfrastructures,Iprovideasummaryofmajordevelopmentsandtrends,focusingontheGlobusopensourceGridsoftwareprojectandtheGriPhyNdatagridproject.
简介:Theelectricindustryisbeingtransformedfromacentralizednetworktoonethatislesscentralizedandallowsmoreconsumerinteractionintheformofasmartgrid.Thereisalsoastrongcommitmentbymostcountriestoreducegreenhousegasemissionsandglobalwarmingthroughtheuseofrenewableenergyresources.Thelocallyavailablerenewableresources,suchaswind,solar,tidal
简介:RecentnovelapproachesinmyocardialperfusionsinglephotonemissionCT(SPECT)havebeenfacilitatedbynewdedicatedhigh-efficiencyhardwarewithsolid-statedetectorsandoptimizedcollimators.Newprotocolsincludeverylow-dose(1mSv)stress-only,two-positionimagingtomitigateattenuationartifacts,andsimultaneousdual-isotopeimaging.Attenuationcorrectioncanbeperformedbyspecializedlow-dosesystemsorbypreviouslyobtainedCTcoronarycalciumscans.HybridprotocolsusingCTangiographyhavebeenproposed.Imagequalityimprovementshavebeendemonstratedbynovelreconstructionsandmotioncorrection.FastSPECTacquisitionfacilitatesdynamicflowandearlyfunctionmeasurements.Imageprocessingalgorithmshavebecomeautomatedwithvirtuallyunsupervisedextractionofquantitativeimagingvariables.Thisautomationfacilitatesintegrationwithclinicalvariablesderivedbymachinelearningtopredictpatientoutcomeordiagnosis.Inthisreview,wedescribenewimagingprotocolsmadepossiblebythenewhardwaredevelopments.WealsodiscussseveralnovelsoftwareapproachesforthequantificationandinterpretationofmyocardialperfusionSPECTscans.
简介:<正>1IntroductionSaltLake,asakindofchemicalresources,hasbeenattractedtomanyresearchers,especiallytheresourcesoflithium.Asreported,manykindsofbrinesexistintheworlddependingonthecompositionsofthebrine.Basedonthechemicalcompositionthebrinescanbeclassifiedasthetypesofchloride,carbonate,sulfate.Fordifferent
简介:Point-basedsurfacehasbeenwidelyusedincomputergraphicsformodeling,animation,visualization,simulationofliquidandsoon.Furthermore,particle-basedapproachcandistributethesurfacesamplingpointsandcontrolitsparametersaccordingtotheneedsoftheapplication.Inthispaper,weexamineseveralkindsofalgorithmspresentedoverthelastdecades,withthemainfocusonparticlesamplingtechnologiesforimplicitsurface.Therefore,weclassifyvariousalgorithmsintocategories,describemainideasbehindeachcategories,andcomparetheadvantagesandshortcomingsofthealgorithmsineachcategory.
简介:Lightweightdesignisoneofthedevelopmenttrendsoftheautomobileindustry.AneffectivewaytoachievelightweightautobodiesistouseAHSS(advancedhighstrengthsteel)forthesafetycomponentsofautomobiles.ThisstudyhastakendoorsillreinforcementsmadeofmartensiteAHSSastheobject,andperformedresearchontheAHSSrollformingtechnologiesandprototypedevelopmentoftypicalasymmetricopencomponents.Bymeansoffiniteelementanalysis(FEA)andsimulation,studieshavebeencarriedoutonthespringbackandedgewavedefectsduringAHSSrollforming,andanoptimizedprocessdesignhasbeenachieved.Thegenerationmechanismsofverticalbows,horizontalcambers,twists,pre-punchedholedistortionandcutendflarehavebeenanalyzed,andsolutionstothesedefectshavebeengiven.Inaddition,tesingoftherollformingprocessforAHSShasbeenconductedandtypicalsampleswithrequireddimensionalaccuracyhavebeenmanufactured.Thisstudyhasprovidedtechnicalsupportforthelarge-scaleapplicationofAHSS.
简介:Large-scaleMIMO(multiple-inputmultiple-output)systemswithnumerouslow-powerantennascanprovidebetterperformanceintermsofspectrumefficiency,powersavingandlinkreliabilitythanconventionalMIMO.Forlarge-scaleMIMO,thereareseveraltechnicalissuesthatneedtobepracticallyaddressed(e.g.,pilotpatterndesignandlow-powertransmissiondesign)andtheoreticallyaddressed(e.g.,capacitybound,channelestimation,andpowerallocationstrategies).Inthispaper,weanalyzethesumrateupperboundoflarge-scaleMIMO,investigateitskeytechnologiesincludingchannelestimation,downlinkprecoding,anduplinkdetection.Wealsopresentsomeperspectivesconcerningnewchannelmodelingapproaches,advanceduserschedulingalgorithms,etc.
简介:Eucalyptusisanimportanttreespeciesontheglobalscale,andalsoitisthemodeltreeinforestgeneticresearch.Therefore,theresearchandapplicationofmolecularmarkingtechnologyinhereditybreedingofEucalyptushaveimportanttheoreticalsignificanceandpracticalvalue.ThispaperdescribedseveralmajormolecularmarkertechnologiesandtheirapplicationtohereditybreedingofEucalyptus,andprospectedthefutureapplicationandstudyofthesetechnologies.