简介:BackgroundNoncompactionofventricularmyocardium(NVM)isararetypeofprimarycardiomyopathy.Thediseaseiscausedbythedisorderinthedensificationofthemyocardiumintheearlystageoftheembryoprocess.Themorphologicalcharacteristicsareprojectingtrabeculationintheventricleandthedeeptrabecularspaceinterlinkedwithventricularchamber.Inrecentyears,manystudieshavefoundthattheleftventriculargrowthassociatedgeneticmutationiscloselyrelatedtotheoccurrenceofNVM.Themostclinicalmanifestationssuchasheartfailure,thromboembolismandarrhythmiaarespecific.EchocardiographyisthemostcommonlyusedtechniqueforthediagnosisofNVM.Cardiaccomputedtomography(CT)scan,cardiacmagneticresonanceimagingandleftventricularangiographyareotherimportanttechniquesforitsdiagnosis.TheNVMpatientshavealongcourseofdisease,poorprognosisandahighrateofmisdiagnosis.Thisarticlereviewstheresearchprogressintheaspectsofepidemiologicalcharacteristics,geneticcharacteristics,clinicalmanifestations,pathophysiology,diagnosis,treatmentandsoon,inordertoprovidethebasisforthediagnosisandtreatmentofNVM.
简介:BackgroundMyocardialfibrosisisoneprocessofthevariousheartdiseases,whichleadstocommonpathologicalchangeswhenitdevelopstoacertainstage.Itisthemaincauseofventricularremodelingwhicheventuallyleadstodifferentdegreesofcardiacdysfunction,malignantarrhythmiasandsuddencardiacdeath.Manystudieshaveshownthatvariouscytokinesplayaveryimportantroleinthedevelopmentofmyocardialfibrosis.Thispaperreviewsthelatestresearchesontheroleofcytokinesinmyocardialfibrosis.
简介:Elevatedheartrateisamajorriskfactorforcardiovasculardiseases.Theinhibitoroffunnycurrent(I(f)),ahyperpolarization-activatedcyclicnucleotide-gatedchannelcurrent,ivabradineisanewagentselectivelyreducingheartratedevoidofothercardiovasculareffects,whichhascomeintothemarketinEuropeformorethan3years.Ithasbeenapprovedthatpureheartratereductionbyivabradinecanimprovemyocardialischemia,endothelialfunctionandmyocardialcontractilefunction.Long-termadministrationwillnotincreaseall-causemortality.Itstherapeuticvalueinstablecoronaryarterydiseasehasbeenverifiedinclinicalpractice,whileinotherfieldsofcardiovasculardiseasesstillneedsmoreevidence-basedmedicalresearch.Thisarticleisareviewaboutitsrecentresearchadvancesinexperimentalandclinicalstudies.
简介:CardiovascularimmunologyresearchinWuhanUnionHospitalbeganin1991.Anti-heartantibodiesindilatedcardiomyopathyandacuteviralmyocarditisbegantobereportedfrom1993.ItwasfoundthatanewautoantibodyagainstL-typecalciumchannelresultsinventriculartachycardiaandsuddendeathinpatientswithdilatedcardiomyopathy.ThroughtheInterventionStudyofDiltiazeminDilatedCardiomyopathy,diltiazemwasverifiedtoreducemortalityandthechronicheartfailurehospitalizationratesignificantlyinpatientswithdilatedcardiomyopathy.TheautoantibodiesagainstangiotensinIIreceptortype1andα1-adrenoceptorwereassociatedwiththeincreasedrecurrenceofanddeathfromstrokeinhypertensivepatients.Throughmanyclinicalandexperimentalstudies,thefunctionalimbalanceofT-cellsubsetswassuggestedtomediatemyocardialinjuryandchronicheartfailure,whichprovidedanewtheoreticalbasisforimmunoregulationtherapyforheartfailure.Thefirstantihypertensivepolypeptidevaccine(ATRQβ-001)wasinvented.Inadditiontotheseachievements,therewillbemoreresearchoncardiovascularimmunologyinWuhanUnionHospitalinthefuture.