简介:目的探讨cyclinD1/D2/D3在大鼠脑胶质瘤组织中的表达。方法将体外培养的大鼠C6胶质瘤细胞(细胞数为3×10^5个)借助动物立体定向仪接种于Wistar大鼠左侧尾状核区,解剖标本,行组织病理学检查及GFAP、cyclinD1/D2/D3免疫组化检测。结果cyclinD1/D2/D3均呈阳性表达。cyclinD1/D3主要在细胞胞核表达,cyclinD2主要在胞浆表达,部分在胞核表达,不同存活期荷瘤鼠瘤组织中cyclinD1/D2/D3表达量不同。结论cyclinD1/D2/D3过分表达参与调节大鼠脑胶质瘤增殖。荷瘤鼠生存期与cyclinD家族蛋白的表达呈负相关关系。
简介:Chapter3 The origins of Angel Clare’s tragedy,[4] Robert Ackerman. Thomas Hardy’s Tess of the D'Urbervilles[M]. Beijing,in his mind was so ingrained that he could not accept Tess’s past. He considers her as a "fallen women". 
简介:Aseriesofidealizedmodelsimulationsareanalyzedtodeterminethesensitivityofmodelresultstodifferentconfigurationsofthelateralboundaryconditions(LBCs)insimulatingmesoscaleshallowconvectionoverhillyterrain.Inthesimulationswithsteadythermalforcingatthemodelsurface,aradiationconditionatbothboundariesisthebestchoiceunderhighwindconditions,andthebestresultsareproducedwhenboththenormalvelocitiesandthetemperaturearetreatedwiththeradiationschemeinwhichthephasespeedisthesamefordifferentvariables.Whenthebackgroundwindspeedisreasonablysmall,theLBCconfigurationwitheithertheradiationorthezerogradientconditionatbothboundariestendstomakethenumericalsolutionunstable.Thechoiceofaconstantconditionattheinflowboundaryandaradiationoutflowboundaryconditionisappropriateinmostcases.Inthesimulationswithdiurnalthermalforcingatthemodelsurface,differentLBCschemesarecombinedtogethertoreducespurioussignalsinducedbytheoutflowboundary.Aspecificationinflowboundarycondition,inwhichthevelocityfieldsattheinflowboundaryareprovidedusingthetime-dependentresultsofasimulationwithperiodicLBCsoveraflatdomain,istestedandtheresultsindicatethatthespecificationconditionattheinflowboundarymakesitpossibletouseasmallermodeldomaintoobtainreasonableresults.Themodelhorizontaldomainlengthshouldbegreaterthanacriticallength,whichdependsonthedomaindepthHandtheanglebetweengravitywavephaselinesandthevertical.Anestimateofminimumdomainlengthisgivenby[(H-zi)/πU]√N2L2x-4π2U2,whereNandUarethebackgroundstabilityandwindspeed,respectively,Lxisthetypicalgravitywavelengthscale,andziistheconvectiveboundarylayer(CBL)depth.
简介:
简介:Solutionstoapiezoelectrichalf-planewithafixedconductorsurfaceelectrodesubjectedtotwogeneralizedsingularities(linedislocationand/orlineforceandfreecharge)arepresented.Coulombforcesactingonthesingularitiesduetotheboundarypolarizationchargesofmediumandtheinductioncharg-esofconductorelectrodeareanalyzedindetail.Theinteractionbetweenthetwosingularitiesisalsoanalyzednumerically.ResultsshowthatCoulombforceswillbecomeimportantasthefreechargeapproachestheboundaryortwosingularitiesmoveclosely.
简介:Amethod,calledTwo-DimensionalExtendedAttributeGrammars(2-DEAGs)fortherecognitionofhand-printedChinesecharactersispresented.Thismethodusesdirectlytwodimensionalinformation,andprovidesaschemefordealingwithvariouskindsofspecificcasesinauniformway.Inthismethod,componentsaredrawninguidedandredundantwayandreductionsaremadelevelbylevejustinaccordancewiththecomponentcombinationrelationsofChinesecharacters.Themethodprovidsalsopolysemousgrammars,coexistinggrammarsandstructureinferringswhihconstrainredundantrecognitionbycomparisonamongsimilarcharactersofcomponentsandgreatlyincreasethetoleranceabilitytodistortion.
简介:摘要:本文基于以传统文化越剧为主题秉持创新、创意、个性等元素内容,打造一款具有独特美术风格弘扬文传统文化越剧的游戏。根据传统越剧特有的剧目、唱、念、做等各种文化打造游戏独特的美术风格,根据传统越剧唱腔所具有的独创性强的特点打造独特的音乐风格。以游戏特有的艺术表达形式融合越剧文化加以趣味性的创新,以弘扬传统越剧文化。
简介:Methetraxate(MTX),aclassicaldihydrofolatereductaseinhibitor,wasasuccessfulclinicalantitumoragent,havingpotentinhibitoryactivitiestoseveralkindsoftumors.Unfortunately,thecancercellkswereeasiertoproduceresistancetoMTXwhichendedinthefailureofchemotherapy.Inordertoovercometheresistanceoftumorcells,anewkindofdihydrofolatereductaseinhibitorscallednonclassicalantifolateincludingtriazines,pyrimidinesandquinazolinesweredesignedandsynthesized.Becauseofthedifferentantitumormechanismsbetweenthetwokindsofcompunds,thecancercellsresistanttoMTXmaystillbesensitivetothenonclassicalantifolate.Accordingtothistheory,somenonclassicalantifolate2,4-diamino-5-methyl-6-(substitutedbenzylamino)quinazolineswiththegeneralstructureshowninFIg.1weresynthesizedandtheirantitumoractivitiesweredeterminedinthisthesis.
简介:StudiesontheSynthesis,the2Dand3DQSARAboutLipophilicAntifolate2,4Diamino5methyl6(SubstitutedBenzylamino)QuinazolineComp...