摘要
AbstractThe immune responses and the function of immune cells among asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection cases, especially in immuno-compromised individuals, remain largely unknown. Here we present a case of asymptomatic SARS-CoV-2 infection that lasted for at least 67 days. The patient has administrated Thymalfasin as 1.6 mg per dose every other day from Day 45 to 70, plus 200 mg per dose Arbidol antiviral therapy three doses per day from Day 48 to 57. Throughout the infection, no anti-SARS-CoV-2 specific IgM or IgG antibodies were detected. Instead, the patient showed either a low percentage or an absolute number of non-classical monocytes, dendritic cells (DCs), CD4+ T cells, and regulatory T cells (Tregs), which may account for the clinical feature and absence of antibody response. This case may shed new light on the outbreak management related to control/prevention, treatment, and vaccination of SARS-CoV-2 and other virus infections in immunocompromised individuals.
机构地区
Jiangmen Central Hospital affiliated with Jiangmen Hospital of Sun Yat-Sen University, Jiangmen 529000, China,Department of Pathogenic Biology, Hebei Medical University, Shijiazhuang, Hebei 050017, China,Guangdong Center for Disease Control and Prevention, Guangzhou 511430, China,State Key Laborator
出版日期
2022年12月13日（中国期刊网平台首次上网日期，不代表论文的发表时间）
