Physical activity responsive miRNAs -- Potential mediators of training responses in human skeletal muscle？

1.ThebasicsofmiRNA-mediatedregulationTheplasticityofskeletalmuscleisofutmostimportanceforrespondingtoandcopingwithenvironmentaldemandsthatemergefromchangesinphysicalactivitypatterns,nourishment,hormonalstatus,andhealth.Asiswellknown,asedentarylifestyle,aging,immobilization,andchronicdiseasesareassociatedwithreducedmusclemassandfunction,whileregularexerciseimprovesmusclefunctionandreducestherateofdecrementthroughoutlife.However,wedonothaveacompleteunderstandingofthemolecularfactorscontrollingskeletalmuscleadaptationtoexercisestimuli.RecentlyidentifiedmicroRNAmolecules(miRNAs)haverapidlygained