Objective:Toobservetheeffectofstatinsonpreventingparoxysmalatrialfibrillation(PAF)afterpacemakerimlantationinpatientswithsicksinussyndrome.MaterialsandMethods:68patientswereselectedinwhichthepacemakershadbeenimplantedduetosicksinussyndrome,andwererandomlypidedintoastatintreatmentgroupandacontrolgroup.Afterthepacemakerimplantation,onlythepatientsintreatmentgroupweregiven20mgatorvastatinoncepernight,withotherconditionsbasicallysimilartothoseinthecontrolgroup.Atthe3rd,9th,15th,and21stmonthsaftertheimplantation,thepacemakerswereprogrammed,andthePAF-relatedinformationstoredinthepacemakerwererecalledandanalyzedstatistically.Results:Aftertheadministrationofstatinsfor9monthssincetheimlantation,theoccurrenceratesofPAFinthetreatmentgroupwasrelativelylowerthanthoseinthecontrolgroup.Afterfurtheradministrationofstatinsfor15months,boththeoccurrencerateofPAFandtheburdenofatrialfibrillationinthetreatmentgrouphadsignificantlydeclined.Aftercontinuousadministrationofstatinsfor21months,boththeoccurrencerateofPAFandtheburdenofatrialfibrillationinthetreatmentgroupweresignificantlylowerthanthoseinthecontrolgroup.Conclusion:Long-termadministrationofstatinscanreducetheriskofPAFaftertheimplantationofapacemakerinpatientswithsicksinussyndrome.
