简介：<正>PRESENTERleproblèmedelamétaphoredansunerevued’étudesfrancaisesenChineestpeut-êtreunpari.Parisurl’universalitédelamétaphore,parisurl’étroitessedesrelationsqu’entretiennentnosdeuxlittératures.

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简介：IhaveworkedandlivedinChinaforexactlysevenyears,andinthelastsevenyearsIhavewitnessedthejoyandtorturemanyyoungpeopleinChinaexperienceintheirendeavortospeakbetterEnglish.Delightedbytheirprogressandconcernedabouttheiranxiety,

简介：Objective:Tomakeaclinicalanalysisonthebasisof36casesofatypicalgenitalherpes(GH)patients.Methods:Thirty-sixcasesofatypicalGHwerediagnosedclinically,andtheircasehistories,symptomsandsignswererecordedindetailandfollowedup.Polymerasechainreaction(PCR)wasadoptedfortestingHSV2-DNAwithcotton-tippedswabs.Enzyme-linkedimmunosorbentassay(ELISA)forserumanti-HSV2-IgMwasdonetoestablishadefinfiivediagnosis.Otherdiagnoseswereexcludedatthesametimebytestingforrelatedpathogensincludingfungi,Chlamydia,Mycoplasma,Treponemapallidum,gonococci,Trichomonas,etc.Results:ThemainclinicalmanifestationsofatypicalGHwere:(1)smallgenitalulcers;(2)inflammationofurethralmeatus;(3)nonspecificgenitalerythema;(4)papuloidnodulesontheglands;(5)nonspecificvaginitis.Twenty-threecases(64%)testedbyPCRwereHSV2-DNAsera-positive,and36cases(100%)anti-HSV2-IgMsera-positivebyELISA.Conclusion:atypicalHSVisdifficulttobediagnosed.ButthecombinationofPCRandELIASwillbehelpfultothediagnosisofatypicalHSV.

简介：WeinvestigatedthepredictedfunctionofproteinseludedfromhumanMHCclassⅡmolecules.PeptidesthatarepresentedbyMHCclassⅡwereobtainedfromtheSYFPEITHIdatabaseandthecorrespondingproteinswerefoundintheSWISSPROTdatabase.Thefunctionsoftheseproteinswerepredictedusingtheprotfunserver.OuranalysisshowedthathumanproteinspresentedbyMHCclassⅡmoleculesarelikelytobeinthecellenvelope,beareceptororinvolvedinimmuneresponses.Presentedproteinsfrombacteriaandvirus,ontheotherhand,aremorelikelytobeinvolvedinregulatoryfunctions,translation,transcriptionaswellasreplication.Theseresultscanleadtobetterunderstandingtheautoimmunityandtheresponsetoinfections.

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简介：毕业答辩是大学生培养的一个重要环节，面临着许多困惑和挑战。把离校前的毕业答辩改变成每一门课程中的一个教学环节——课程答辩，从一次结果变成贯穿整个培养过程，使学生的口头表达能力、文字写作能力、实践创新能力等综合素质能力得以训练和提高，这就是Presenta—tion法。该法实现了学生角色的转变，变被动学习为主动学习，变灌输式为探索和研究，使教学的时间和空间得以扩展，对教师也提出了更高的要求。

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简介：AbstractIntroduction:Malignant syphilis (MS) is a rare and severe variant of secondary syphilis that is frequently associated with HIV infection. The clinical impact of HIV and syphilis co-infection is bidirectional, and the presence of MS is associated with acute HIV infection. Clinically, MS is characterized by nodular and ulcerative lesions affecting the trunk and extremities, which are covered with thick crusts. The treatment of choice for MS remains benzathine penicillin G. Herein, we report a case in which MS was the initial presentation of HIV infection.Case presentation:A 35-year-old male patient came with the chief complaint of extensive erythematous nodular rash for the past one month, with notable ulceration on some lesions with annular configuration along with fever and malaise. Based on the abovementioned clinical, laboratory, and histopathologic findings, the patient was diagnosed with MS and HIV. The diagnosis was established based on histopathological examination and syphilis serological testing.Discussion:Cutaneous disorders are a frequent presenting feature of HIV infection. The clinical manifestations of syphilis in immunosuppressed patients are often severe and/or atypical. The patient was then treated with weekly intramuscular administration of 2.4 million units of benzathine penicillin G for 3 weeks and achieved rapid and significant clinical improvement, with no Jarisch-Herxheimer reaction.Conclusion:Co-infection with syphilis and HIV alters the course of both diseases, and most HIV-infected patients with syphilis have typical disease manifestations associated with decreased CD4+ T-cell counts.

简介：AbstractLeopard attacks on humans are reported most often from the Indian subcontinent. The bite wounds are complex injuries infected with polymicrobial inoculum and may present as punctures, abrasions, lacerations or avulsions. The presentation and acceptable treatment of these injuries vary according to the wound. We hereby describe the clinical presentation and treatment of a male victim with leopard bite injuries on the head and neck region. As bite injuries are commonly found on and around the face, maxillofacial surgeons should be familiar with the therapy. Through thorough clinical and radiological examination, it is essential to prevent missing any hidden injuries, which can easily turn lethal. To benefit the rural population, more health facilities need to be established in remote areas.

简介：AbstractObjective:This study aims to describe presenting characteristics of patients diagnosed with non-invasive chronic rhinosinusitis (CRS) following liver or kidney transplant and determine factors associated with disease-related complications, selection of endoscopic sinus surgery (ESS), and disease resolution in this population.Study design:Retrospective chart review.Setting:An academic tertiary care center (Mayo Clinic, Rochester, Minnesota).Subjects and methods:Liver and kidney transplant recipients evaluated by Mayo Clinic otolaryngologists for CRS between 1998 and 2018 were identified. Univariate and multivariate logistic regression analyses were used to determine patient factors and treatment modalities associated with developing complications, selection of ESS, and disease resolution.Results:Fifty-seven patients met inclusion criteria. No patients developed intraorbital or intracranial complications of their CRS. Multivariate modeling demonstrated that the presence of polyps (P = 0.036) was associated with undergoing ESS within one year of presentation. A higher Lund-Mackay (LM) computed tomography score (P = 0.023) and older age (P = 0.018) were significantly associated with decreased disease resolution. No other factors were significantly associated with the use of endoscopic sinus surgery within one year of otolaryngology presentation or resolution of CRS in this cohort.Conclusion:The risk of developing CRS-related intraorbital or intracranial complications in this immunecompromised patient cohort may be lower than originally thought. For liver- and kidney-recipients stable on immunosuppressive medication for many years, prognostic factors for CRS may mirror those for immunocompetent patients.

简介：AbstractBackground:The COVID-19 novel coronavirus is contagious, and the mortality is higher in the elderly population. Lockdown in different parts of the world has been imposed since January 2020. Chronic subdural haematoma (cSDH) has a unique natural history in which symptoms can be non-specific, and the onset is insidious. This study aims to evaluate the impact of the COVID-19 pandemic on the presentation of cSDH.Methods:Consecutive adult cSDH patients admitted from 1 March 2020 to 30 April 2020 were reviewed. Exclusion criteria including those who had no definite history of head injury or the diagnosis of cSDH were made from a scheduled follow-up scan. Corresponding data during the same period in 2019 were reviewed for comparison. The primary outcome was the interval between the initial head injury and the final radiological diagnosis of cSDH. Secondary outcomes include Markwalder chronic subdural haematoma grade upon admission, length of stay in the acute hospital, and the modified Rankin scale (mRS) upon discharge.Results:For the primary outcome, the average interval between head injury and the diagnosis of cSDH was significantly longer at 56.6 days (49 to 74 days, SD 9.83 days) during the period from March to April 2020, versus 29.4 days (17 to 42 days, SD 8.59 days) in 2019 for the corresponding period (p = 0.00703). There was no significant difference in the functional outcome upon discharge.Conclusions:cSDH patients can present late during the COVID-19 lockdown period. The functional outcome was comparable when operations for drainage were timely performed.

简介：SinkiangMuqammusic,whichisacombinationofsong,dance,music,folk-customandliterature,isinthelistofWorldIntangibleCulturalHeritage.ItisdistributedindifferentregionsinSinkiang.Becauseofthedifferentinheritanceregionsaswellasthedifferentinfluenceofhistoryandculture,thereformedMuqammusicofdifferentregionstyle,furtherpresenteddifferentartisticstyle.ThisarticlepresentsamethodtointuitivelyshowtheinheritancedistributionoffourkindsofMuqammusicinSinkiangbasedonscalablevectorgraphicstechnology,itprovidesmethodsandtoolsofvisualizationresearchontheprotectionandinheritanceofMuqammusic.

简介：SignificanceofECGChangesinAcuteMyocardialInfarctionSTsegmentelevationisconsideredbymostasasignofanoccludedcoronaryarteryandmyocardialischemia.CoronaryarteryocclusionusuallyisthecauseoftheacuteinfarctioninthepatientwiththattypeofECG.PatientswithacutemyocardialinfarctionwhodonotshowSTsegmentelevationyetleaktroponin,stillhaveamyocardialinfarction.

简介：学生课堂展示在教学实践中的应用可通过预习、展示和小组合作等进行。学生课堂展示是提高初中英语教学质量的有效途径。

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简介：1.IntroductionTheresearchontheCognitivepresentationofTEFLinformationintheChinesesettingisaprovincialresearchprojectsetupinJanuary,1995.ThepurposeistoexplorehowTEFLinformationshouldbePre-sentedcognitively(forEnglishmajorsinChineseteachers’colleges.AsisrevealedbyourtheoreticalpresantationoflanguagepsycholnginAnAnalysisoftheSemioticGrowthandDevelopmentofLanguageandinthisreport,theprojecthasachievedbohsomeimportantpsyhologicaldiscoveriesconcernedwithlanguage,languageleamingandlanguageteaching,amdanexperimentalsuccess.ItisbelievedbythisauthorthatthosediscoverieshaveimportantpracticalvaluesinCinaaswellastheoreticalvaluesforthevatiousstudiesoflanguage.1.1SourcetheoriesfortheprojectBeforetheprojectwassatup,wehadalreadydonetwootherteachingexperimentswhichwerebasedonourtheoreticallesearchesinsuchareasaslanguage,languagepsychologyandteachingmethodology,Thosediscoverieswereerpressedi

简介：OBJECT:Optimummanagementforelderlypatientswithnewlydiagnosedglioblastoma(GBM)inthetemozolomide(TMZ)eraisnotwelldefined.Theobjectofthisstudywastoclarifyoutcomesinthispopulation.METHODS:Theauthorsretrospectivelyreviewed105consecutivecasesinvolvingelderlypatients(age≥65years)withnewlydiagnosedGBMwhoweretreatedattheMayoClinicbetween2003and2008.RESULTS:Thepatients'medianagewas74years(range66-87years),andthemedianKarnofskyPerformanceStatus(KPS)scorewas80(range40-90).Halfofthepatientsunderwentbiopsyandhalfunderwentresection.Patientswithdeep-seatedlesions(19patients[18%])ormultifocallesions(34patients[32%])weremorelikelytohavebiopsythanresection(p=0.0001and0.0009,respectively).Newpersistentneurologicaldeficitsdevelopedin7patients(6.7%).Postoperativehemorrhageoccurredin6patients(5.7%),allofwhomunderwentbiopsy.Completefollow-updataregardingadjuvanttreatmentwasavailablein84patients.Forty-one(49%)weretreatedwithchemotherapy(mostlyTMZ)andradiationtherapy(RT),and23(27%)withRTalone.Nineteen(23%)receivedonlypalliativecareaftersurgery(morecommonwithbiopsy,p=0.03).Chemotherapycomplicationsoccurredin28.6%(Grade3or4hematologicalcomplicationsin11.9%).Themedianvaluesforprogression-freesurvival(PFS)andoverallsurvival(OS)were3.5and5.5months.Inamultivariateanalysis,youngerage(p=0.03,riskratio[RR]0.34,95%CI0.13-0.89),singlelesion(p=0.02,RR0.51,95%CI0.30-0.89),resection(p=0.04,RR0.54,95%CI0.31-0.94),andadjuvanttreatment(p=0.0001,RR0.24,95%CI0.11-0.49)wereassociatedwithbetterOS.OnlyadjuvanttreatmentwassignificantlyassociatedwithprolongedPFS(p=0.0007,RR0.27,95%CI0.13-0.57).Withcombinedtherapywithresection,RT,andchemotherapy,themedianPFSandOSwere8and12.5months,respectively.CONCLUSIONS:TheprognosisforGBMworsenswithincreasingageinelderlypatients.Withimportantrisks,resectionandadjuvanttreatmen