简介：Activehost-pathogeninteractionstakeplaceduringinfectionofhumanimmunodeficiencyvirustype1(HIV-1).Outcomesoftheseinteractionsdeterminetheefficiencyofviralinfectionandsubsequentdiseaseprogression.HIV-infectedcellsrespondtoviralinvasionwithvariousdefensivestrategiessuchasinnate,cellularandhumoralimmuneantiviralmechanisms.Ontheotherhand,thevirushasalsodevelopedvariousoffensivetacticstosuppressthesehostcellularresponses.Amongmanyoftheviraloffensivestrategies,HIV-1viralauxiliaryproteins(Tat,Rev,Nef,Vif,VprandVpu)playimportantrolesinthehost-pathogeninteractionandthushavesignificantimpactsontheoutcomeofHIVinfection.OneofthebestexamplesistheinteractionofVifwithahostcytidinedeaminaseAPOBEC3G.AlthoughspecificrolesofotherauxiliaryproteinsarenotaswelldescribedasVif-APOBEC3Ginteraction,itisthegoalofthisbriefreviewtosummarizesomeofthepreliminaryfindingswiththehopetostimulatefurtherdiscussionandinvestigationinthisexhilaratingareaofresearch.

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