简介:摘要目的分析小儿黏多糖病的临床、实验室和X线检查特点。方法对2006年10月-2009年12月诊治的41例黏多糖病患儿的临床症状、体征、骨骼X线改变和尿黏多糖酸测定结果进行回顾性分析。结果41例患儿均呈现生长落后、身材矮小、骨骼畸形,其中特殊面容35例,智力低下15例,语言障碍13例,共济失调19例,角膜混浊18例,听力障碍12例,爪形手36例,心前区闻及收缩期杂音8例,窦速5例,肝大20例,脾大9例,脐疝6例,腹股沟斜疝5例,皮肤干、粗糙12例.尿黏多糖定性阳性30例,24h尿黏多糖异常10例.X线呈典型改变38例(93%)。结论X线检查是协助临床诊断黏多糖病的主要手段,目前该病无特效治疗方法,预后差.早期诊断、早期治疗,可以改善临床表现。
简介:仙人掌多糖具有明显的增强免疫、抗肿瘤、降血糖、抗氧化、抗衰老等活性,是仙人掌具有多种功效的原因之一。本文主要综述了仙人掌多糖的提取、分离纯化方法和生物活性的研究进展。
简介:Toverifytheanti-tumoureffectsofpolyscaccharideisolatedfromTangerineskinonmicetransplantabletumour,andtodevelopanewanticancerdrugfromplant.MiceweretransplantedwithS-180sarcomaorEhrhch'sasciticcarcinomaandhumanhysterotrachecarcinomaHelaceli.Drugsweregivendaily,byoraladministration.Forsevendays,ontheeighthdayanimalsweresacrificed.Peripheralbloodcellcounts,aswellasplasmasupemxidedismutase(SOD),malondialdehyde(MDA)andredbloodcellimmunityfunctiondetermination.TheinhibitionrateofTangerineskinpolysaccharideformiceS-180andEACwere21.6%and27.3%respectively.'FneeffecttoHealcellweredeteminedbyMTT.TheeffectofTangerineskinpolysccharideonperipheralbloodcountswereincreasednumbersofperipheralleukocytesandlymphocytes,theTangerineskinpolysaccharidegroupwashigherthanAnliurugroup(P<0.01).PlasmSODactivitywereincreased,MDAcontentdepressed,butnodifference.Redbloodceilimmunefunctionincreased(P<0.01).TheinhibitionrateforhumanhysterotrachecarcinomaHelaceilwere52.4%,63.0%and72.0%.Tangerineskinpolysaccharideexhibitedanti-canceractivityandmayincreaseperipheralleucocytecountandnumberoflymphocytesandenhanceimmunompetece.Itispromisinginadjuvanttherapy.Furtherstudyisworthcontinuing.