简介:目的观察实验性铅中毒对大鼠海马和大脑皮质一氧化氮合酶(NOS)性的影响,探讨NOS在铅中毒中枢系统损害中的作用机制。方法4周龄Wistar雄性大鼠按45mg/kg剂量行醋酸铅灌胃30d;大鼠海马和大脑皮质总NOS和诱导型一氧化氮合酶(iNOS)活性测定采用NOS催化L-Arg和氧分子生成NO法。结果与空白对照纽大鼠比较,染铅组大鼠海马和大脑皮质总NOS活性明显降低,而iNOS活性均升高,差异有显著性(P〈0.01)。结论铅可以使大鼠海马和大脑皮质总NOS活性降低,iNOS活性升高。
简介:摘要目的探讨大面积大脑半球梗死患者的少见病因、临床特点及结局.方法对13例少见病因所致的大面积大脑半球梗死患者的病因、临床特点及结局进行分析.结果13例患者中有6例不存在任何常见脑血管病危险因素,余7例患者中,3例为自发性颈动脉夹层,1例为moyamoya病,1例为升主动脉夹层动脉瘤,1例为真性红细胞增多症,1例为脑出血血肿清除术后继发同侧半球大面积脑梗死.11例(84.6%)患者在住院期间发生了神经系统及全身并发症,4例患者行去骨瓣减压术.至3月随访期末,6例患者死亡,存活者中仅1例生活基本自理,余6例均遗留中至重度残疾.结论大面积大脑半球梗死病因搜索过程中应重视病史询问.少见病因大面积大脑半球梗死患者虽更年轻,有更少的合并症,整个病情发展仍极其凶险,预后极差.关键词大面积大脑半球梗死;病因;预后Unusualcausesof1argehemisphereinfarctionacaseseriesof13patientsAbstractobjectiveToexplorethepathogenesis,characteristicsandoutcomeoflargehemisphereinfarctionofunusualcauses.MethodsThirteencasesoflargehemisphereinfarctionofunusualcauseswereprospectivelyregisteredandanalyzedtheirstrokepathogenesis,clinicalcharacteristicsandclinicaloutcome.ReGsultsAmongthe13patients,10wereundertheageof60yearsold.Mostofthepatientswereinacriticalconditiononadmission.12sufferedconsciousdisturbGanceonadmissionand5withcoma.Thepatientssufferedstroke-relatedneurologicalormedicalcomplicationsduringhospitalizationand4underwentdecompresGsivesurgery.InclusionAdetailedpatienthistoryisofgreatimportanceinthepathogenesisoflargehemisphereinfarctionespeciallyforyoungerpatients.AlGthoughpatientswithlargehemisphereinfarctionofunusualcausesareyoungerandwithlesscomorbidities,theirexpectedclinicalcourseareseriousandmostlyhaveaKpeoyorwoorudtscome.largehemisphereinfarction,pathogenesis,outcome中图分类号R733文献标识码B文章编号1008-6315(2015)12-0905-01
简介:摘要 目的:富集制备白及抗炎活性部位,测定其抗炎活性。方法:以聚酰胺柱色谱乙醇梯度洗脱法富集白及抗炎活性成分,并采用LPS诱导的RAW264.7巨噬细胞炎症模型测定其抗炎活性。结果:白及醇提取物与聚酰胺按重量比1:4混合,减压浓缩至无醇味,混悬物装柱,20%乙醇洗脱去杂,收集40%乙醇洗脱物,减压干燥得白及药效部位。该药效部位可剂量依赖性抑制LPS诱导的RAW264.7细胞IL-6和TNF-α表达,表现出较好抗炎活性。结论:聚酰胺柱色谱法对白及抗炎活性成分具有较好富集作用,所制备的药效部位具有较强的抗炎活性,这为今后白及开发利用奠定了良好基础。