简介:Inthispaperexhaustive-servicepriority-M/G/1queueingsystemswithmultiplevacations,singlevacationandsetuptimesarestudiedunderthenonpreemptiveandpreemptiveresumeprioritydisciplines.Foreachofthesixmodelsanalysed,theLapLace-StieltjestransformofthevirtualwaitingtimeWκ(t)attimetofclasskisderivedbythemethodofcollectivemarks.AsufficientconditionforWκ(t)/√ακdd↑→|U|,whereUhasthestandardnormaldistribution,isalsogiven.
简介:摘要:本文从电信联通5G低频800M和900M共享的必要性、共享的可行性、低频共享技术的挑战与解决方案、低频共享技术的效益等方面对电信联通5G低频共享作了详细分析,在5G低频网络共建共享方面具有一定的指导意义。
简介:无
简介:BystudyingthespectralpropertiesoftheunderlyingoperatorcorrespondingtotheM/G/1queueingmodelwithoptionalsecondserviceweobtainthatthetime-dependentsolutionofthemodelstronglyconvergestoitssteady-statesolution.Wealsoshowthatthetime-dependentqueueingsizeatthedeparturepointconvergestothecorrespondingsteadystatequeueingsizeatthedeparturepoint.
简介:Glioblastoma(GBM)isoneofthedeadliesttumorsandhasamediansurvivalof3monthsifleftuntreated.Despiteadvancesinrationallytargetedpharmacologicalapproaches,theclinicalcareofGBMremainspalliativeinintent.Sincethemajorityofalteredsignalingcascadesinvolvedincancerestablishmentandprogressioneventuallyaffectcellcycleprogression,analternativeapproachforcancertherapyistodevelopinnovativecompoundsthatblocktheactivityofcrucialmoleculesneededbytumorcellstocompletecelldivision.Inthiscontext,wereviewpromisingongoingandfuturestrategiesforGBMtherapeuticsaimedtowardsG2/Minhibitionsuchasanti-microtubuleagentsandtargetedtherapyagainstG2/Mregulatorslikecyclin-dependentkinases,Aurorainhibitors,PLK1,BUB,1,andBUBR1,andsurvivin.Moreover,wealsoincludeinvestigationalagentsinthepreclinicalandearlyclinicalsettings.Althoughseveraldrugswereshowntobegliotoxic,mostofthemhavenotyetenteredtherapeutictrials.TheuseofeithersingleexposureoracombinationwithnovelcompoundsmayleadtotreatmentalternativesforGBMpatientsinthenearfuture.