简介：Objective:ActivatingKRASmutationsarethemostcommondriversinthedevelopmentofnon-smallcelllungcancer(NSCLC).However,unsuccessoftreatmentbydirectinhibitionofKRAShasbeenproven.DeregulationofPI3KsignalingplaysanimportantroleintumorigenesisanddrugresistanceinNSCLC.TheactivityofPI3Kα-selectiveinhibitionagainstKRAS-mutatedNSCLCremainslargelyunknown.Methods:CellproliferationwasdetectedbysulforhodamineBassay.Cellcycledistributionandapoptosisweremeasuredbyflowcytometry.CellsignalingwasassessedbyWesternblotandimmunohistochemistry.RNAinterferencewasusedtodown-regulatetheexpressionofcyclinD1.HumanNSCLCxenograftswereemployedtodetecttherapeuticefficacyinvivo.Results:CYH33possessedvariableactivityagainstapanelofKRAS-mutatedNSCLCcelllines.AlthoughCYH33blockedAKTphosphorylationinalltestedcells,RbphosphorylationdecreasedinCYH33-sensitive,butnotinCYH33-resistantcells,whichwasconsistentwithG1phasearrestinsensitivecells.CombinedtreatmentwiththeCDK4/6inhibitor,PD0332991,andCYH33displayedsynergisticactivityagainsttheproliferationofbothCYH33-sensitiveandCYH33-resistantcells,whichwasaccompaniedbyenhancedG1-phasearrest.Moreover,down-regulationofcyclinD1sensitizedNSCLCcellstoCYH33.Reciprocally,CYH33abrogatedthePD0332991-inducedup-regulationofcyclinD1andphosphorylationofAKTinA549cells.Co-treatmentwiththesetwodrugsdemonstratedsynergisticactivityagainstA549andH23xenografts,withenhancedinhibitionofRbphosphorylation.Conclusions:SimultaneousinhibitionofPI3KαandCDK4/6displayedsynergisticactivityagainstKRAS-mutatedNSCLC.ThesedataprovideamechanisticrationaleforthecombinationofaPI3KαinhibitorandaCDK4/6inhibitorforthetreatmentofKRASmutatedNSCLC.

简介：Objective:Europeanlungcancerscreeningstudiesusingcomputedtomography(CT)haveshownthatamanagementprotocolbasedonmeasuringlungnodulevolumeandvolumedoublingtime(VDT)ismorespecificforearlylungcancerdetectionthanadiameter-basedprotocol.However,whetherthisalsoappliestoaChinesepopulationisunclear.Theaimofthisstudyistocomparethediagnosticperformanceofavolume-basedprotocolwithadiameter-basedprotocolforlungcancerdetectionandoptimizethenodulemanagementcriteriaforaChinesepopulation.Methods:Thisstudyhasapopulation-based,prospectivecohortdesignandincludes4000participantsfromtheHexidistrictofTianjin,China.Participantswillundergolow-dosechestCTatbaselineandafter1year.Initially,detectedlungnoduleswillbeevaluatedfordiameterandmanagedaccordingtoaroutinediameter-basedprotocol(ClinicalPracticeGuidelineinOncologyforLungCancerScreening,Version2.2018).Subsequently,lungnoduleswillbeevaluatedforvolumeandmanagementwillbesimulatedaccordingtoavolume-basedprotocolandVDT(aEuropeanlungnodulemanagementprotocol).Participantswillbefollowedupfor4yearstoevaluatelungcancerincidenceandmortality.TheprimaryoutcomeisthediagnosticperformanceoftheEuropeanvolume-basedprotocolcomparedtodiameter-basedmanagementregardinglungnodulesdetectedusinglow-doseCT.Results:Thediagnosticperformanceofvolume-anddiameter-basedmanagementforlungnodulesinaChinesepopulationwillbeestimatedandcompared.Conclusions:Throughthestudy,weexpecttoimprovethemanagementoflungnodulesandearlydetectionoflungcancerinChinesepopulations.

简介：Objective:ToexaminetheeffectofpSer9-GSK-3βonbreastcancerandtodeterminewhethertheunderlyingmetabolicandimmunologicalmechanismisassociatedwithROS/eIF2Bandnaturalkiller(NK)cells.Methods:WeemployedTWS119toinactivateGSK-3βbyphosphorylatingSer9andexploreditseffectonbreastcancerandNKcells.TheexpressionofGSK-3β,naturalkillergroup2memberD(NKG2D)ligands,eIF2BwasquantifiedbyPCRandWesternblot.Wemeasuredintracellularreactiveoxygenspecies(ROS)andmitochondrialROSusingDCFH-DAandMitoSOXTMprobe,respectively,andconductedquantitativeanalysisofcellularrespirationon4T1cellswithmitochondrialrespiratorychaincomplexⅠ/Ⅲkits.Results:OurinvestigationrevealedthatTWS119downregulatedNKG2Dligands(H60aandRae1),suppressedthecytotoxicityofNKcells,andpromotedthemigrationof4T1murinebreastcancercells.Nevertheless,LY290042,whichattenuatesp-GSK-3βformationbyinhibitingthePI3K/Aktpathway,reversedtheseeffects.WealsofoundthathigherexpressionofpSer9-GSK-3βinducedhigherlevelsofROS,andobservedthatabnormalityofmitochondrialrespiratorychaincomplexⅠ/ⅢfunctioninducedthedysfunctionofGSK-3β-inducedelectrontransportchain,naturallydisturbingtheROSlevel.Inaddition,theexpressionofNOX3andNOX4wassignificantlyup-regulated,whichaffectedthegenerationofROSandassociatedwiththemetastasisofbreastcancer.Furthermore,wefoundthattheexpressionofpSer535-eIF2BpromotedtheexpressionofNKG2Dligands(Mult-1andRae1)followingbyexpressionofpSer9-GSK-3βandgenerationofROS.Conclusions:ThePI3K/Akt/GSK-3β/ROS/eIF2BpathwaycouldregulateNKcellactivityandsensitivityoftumorcellstoNKcells,whichresultedinbreastcancergrowthandlungmetastasis.Thus,GSK-3βisapromisingtargetofanti-tumortherapy.

简介：Qidong(Jiangsu,China)hasbeenofinteresttocancerepidemiologistsandbiologistsbecause,untilrecently,itwasanendemicareaforlivercancer,havingamongstthehighestincidenceratesintheworld.TheestablishmentoftheQidongCancerRegistrytogetherwiththeQidongLiverCancerInstitutein1972haschartedthepatternsoflivercancerincidenceandmortalityinastablepopulationthroughoutaperiodofenormouseconomic,social,andenvironmentalchangesaswellasofimprovementsinhealthcaredelivery.UpdatedincidencetrendsinQidongaredescribed.Notably,theChinaage-standardizedincidencerateforlivercancerhasdroppedbyover50%inthepastseveraldecades.MolecularepidemiologicandgenomicdeepsequencingstudieshaveaffirmedthatinfectionwithhepatitisBvirusaswellasdietaryexposuretoaflatoxinsthroughcontaminationofdietarystaplessuchascorn,andtomicrocystins–blue-greenalgaltoxinsfoundinditchandpondwater–werelikelyimportantetiologicfactorsthataccountforthehighincidenceoflivercancerinthisregion.PublichealthinitiativestofacilitateuniversalvaccinationofnewbornsagainstHBVandtoimprovedrinkingwatersourcesinthisruralarea,aswellaseconomicandsocialmandatesserendipitouslyfacilitatingdietarydiversity,haveledtoprecipitousdeclinesinexposurestotheseetiologicfactors,concomitantlydrivingsubstantivedeclinesinthelivercancerincidenceseennowinQidong.Inthisregard,Qidongservesasatemplatefortheglobalimpactthatapackageofinterventionstrategiesmayexertoncancerburden.

简介：ChimonanthusplantswidelydistributedinsouthernareaofChina,whichhavealonghistoryofediblesandmedicine.PhytochemicalinvestigationshaveshownthatChimonanthusproduced143non-volatileconstituents,includingalkaloids,flavonoids,terpenoids,coumarinsandothers,whichexhibitsignificantanti-oxidant,anti-bacterial,anti-cancer,anti-inflammatory,antihyperglycemic,antihyperlipidemicandotherbiologicalactivities.Onthebasisofsystematicreviewingofliteratures,thisarticleoverviewsthenon-volatileconstituentsandpharmacologyofChimonanthusfromdomesticandforeignoverthelast30years(untilJune2018),andmayprovideausefulreferenceforthefurtherdevelopmentofChimonanthus.

简介：Foranygivenpositiveintegerm,letXi,1≤i≤mbemindependentrandomvariableswithdistributionsFi,1≤i≤m.Whenallthesummandsarenonnegativeandatleastoneofthemisheavy-tailed,weprovethatthelowerlimitoftheratioP(∑i=1^mXi>x)/∑i=1^mFi(x)equals1asx→∞.Whenthesummandsarereal-valued,wealsoobtainsomeasymptoticresultsforthetailprobabilityofthesums.Besides,alocalversionaswellasadensityversionoftheaboveresultsisalsopresented.

简介：Theeffectoffullysubmergedbouldersontheflowstructureinchannelshasbeenstudiedbysomeresearchers.However,manynaturalstreamshavebedmaterialwithbouldersthatarenotfullysubmergedunderwater.Inmanynaturalstreams,boulderscoverbetween1%and10%oftheareaofthestreamreach.Theeffectofnon-submergedbouldersonthevelocityprofileandflowcharacteristicsisveryimportantforassessingriverbeddeformation.Theobjectivesofthispaperaretofindthepatternofvelocitydistributionaroundanon-submergedboulderandtocompareitwiththeclassicalstudiesonflowresistanceandReynoldsstressdistributioninopenchannels.Also,byconsideringthevariationintheReynoldsstressdistributionatdifferentlocationsaroundanon-submergedboulder,theeffectofanon-submergedboulderontheestimationofshearvelocityandresistancetoflowhasbeeninvestigated.Resultsindicatesthatinsidethescourholecausedbyanon-submergedboulderinarivervelocitydistributionsareirregular.However,velocitydistributionsareregularoutsidethescourhole.ThepresenceofthebouldercausesaconsiderabledeviationoftheReynoldsshearstressfromtheclassicdistribution,showinganon-specificdistributionwithnegativevalues.TheclassicalmethodsforcalculatingshearvelocityarenotsuitablebecausethesemethodsdonotgivedetailedvelocityandReynoldsstressdistributionsinnaturalriverswithalotofboulders.Thus,theeffectofanon-submergedboulderontheestimationoftheresistancetoflowbyconsideringthevariationsinvelocityandReynoldsstressdistributionsatdifferentlocationsaroundanon-submergedboulderisimportantandneedstobestudiedinanaturalriverinsteadofjustinlaboratoryflumes.ThenegativevaluesinReynoldsstressdistributionaroundaboulderindicatethattheclassicalmethodsareunabletopredictresistancetoflow,andalsoshowstrongturbulenceinsidethescourholewherethecomplexflowconditionspresentambi

简介：Overthepastdecades,cellsurfacecharge,althoughexperimentallyobserved,hasnotbeenwellunderstoodparticularlyfromtheviewpointofbiophysics.Ourrecentstudieshaveshownthatallcancercellsexhib让negativesurfacechargesthataredirectlyproportionaltothesecretedlacticacid,auniquecancermetaboliccharacteristic:highrateofglycolysis.Wehavethereforedesignedanddevelopedasetofelectrically-charged,fluorescent,andsuper-paramagneticnanoprobes,capableofsensitivedetectionofcancercellsbasedonthesurfacecharges.Theseprobesareutilizedtobindontocellsviaelectrostaticreactionforcaptureandmagneticseparation.Inthisfashion,weareabletocharacterizecellsurfacechargesthatareregulatedbydifferentmetabolicpatterns,thereforeeffectivelydistinguishingthecancercellsfromthenormalcells.All22cancercellsofdifferentorgansarefoundtobenegativelychargedthereforeboundstronglybythepositively-chargednanoprobes,whereasthenormalcellsshowinsignificantbindingtothenanoprobesofeitherchargesigns(positiveornegative).Thisfindingsuggeststhatalltestedcancercellsarenegatively-chargedandnormalcellsareeithercharge-neutralorslightlypositive.Fordiagnosis,cancercellscanbedetected,electrostaticallybound,andmagneticallyseparatedinbloodbychargedandsuper-paramagneticnanoprobes.Intherapeutics,circulatingcancercells(CTCs)canbefilteredandremovedinacontinuousfashiontoreducetheriskofcancermetastasis.Ifsuccessful,thisnewnanotechnologywillrevolutionizeearlycancerdiagnosisandpotentiallyenablenewtherapeuticsinclinicalsettings.

简介：Inthispaper,thebehaviorforcommutatorsofaclassofbilinearsingularintegraloperatorsassociatedwithnon-smoothkernelsontheproductofweightedLebesguespacesisconsidered.BysomenewmaximalfunctionstocontrolthecommutatorsofbilinearsingularintegraloperatorsandCMO(Rn)functions,compactnessforthecommutatorsisproved.

简介：Theinsectmidgutepitheliumiscomposedofcolumnar,goblet,andregenerativecells.Columnarepithelialcellsarethemostabundantandhavemembraneprotrusionsthatformthebrushbordermembrane(BBM)ontheirapicalside.Theseincreasesurfaceareaavailableforthetransportofnutrients,butalsoprovideopportunitiesforinteractionwithxenobioticssuchaspathogens,toxinsandhostplantallelochemicals.RecentimprovementsinproteomicandbioinfbrmaticstoolsprovidedanopportunitytodeterminetheproteomeoftheT.niBBMinunprecedenteddetail.ThisstudyreportstheidentificationofproteinsfromBBMvesicles(BBMVs)usingsingledimensionpolyacrylamidegelelec?trophoresiscoupledwithmulti-dimensionalproteinidentificationtechnology.Morethan3000proteinswereassociatedwiththeBBMVofwhich697werepredictedtopossesseitherasignalpeptide,atleastonetransmembranedomainoraGPI-anchorsignal.Ofthese,bioinfbrmaticsanalysisandmanualcurationpredictedthat185maybeassociatedwiththeBBMVorepithelialcellplasmamembrane.Thesearediscussedwithrespecttotheirpredictedfunctions,namelydigestion,nutrientuptake,cellsignaling,development,cell-cellinteractions,andotherfunctions.Webelievethistobethemostdetailedproteomicanalysisofthelepidopteranmidgutepitheliummembranetodate,whichwillprovideinformationtobetterunderstandthebiochemical,physiologicalandpathologicalprocessestakingplaceinthelarvalmidgut.

简介：Non-equilibriumturbulencephenomenahaveraisedgreatinterestsinrecentyears.Significanteffortshavebeendevotedtonon-equilibriumturbulencepropertiesincanonicalflows,e.g.,gridturbulence,turbulentwakes,andhomogeneousisotropicturbulence(HIT).Thenon-equilibriumturbulenceinnon-canonicalflows,however,hasrarelybeenstudiedduetothecomplexityoftheflows.Inthepresentcontribution,adirectnumericalsimulation(DNS)databaseofaturbulentflowisanalyzedoverabackwardfacingramp,theflowneartheboundaryisdemonstrated,andthenon-equilibriumturbulentpropertiesoftheflowinthewakeoftheramparepresentedbyusingthecharacteristicparameterssuchasthedissipationcoefficientCεandtheskewnessoflongitudinalvelocitygradientSk,butwithoppositeunderlyingturbulentenergytransferproperties.TheequationofLagrangianvelocitygradientcorrelationisexamined,andtheresultsshowthatnon-equilibriumturbulenceistheresultofphasede-coherencephenomena,whichisnottakenintoaccountinthemodelingofnon-equilibriumturbulence.Thesefindingsareexpectedtoinspiredeeperinvestigationofdifferentnon-equilibriumturbulencephenomenaindifferentflowconditionsandtheimprovementofturbulencemodeling.

简介：Anextendedelectronmodelfullyrecoversmanyoftheexperimentalresultsofquantummechanicswhileitavoidsmanyofthepitfallsandremainsgenerallyfreeofparadoxes.TheformulationofthemanybodyelectronicproblemhereresemblestheKohnShamformulationofstandarddensityfunctionaltheory.However,ratherthanreferringelectronicpropertiestoalargesetofsingleelectronorbitals,theextendedelectronmodelusesonlymassdensityandfieldcomponents,leadingtoasubstantialincreaseincomputationalefficiency.Todate,theHohenberg-Kohntheoremshavenotbeenprovedforamodelofthistype,norhasauniversalenergyfunctionalbeenpresented.Inthispaper,weaddresstheseproblemsandshowthattheHohenbergKohntheoremsdoalsoholdforadensitymodelofthistype.Wethenpresentaproof^of^conceptpracticalimplementationofthismethodandshowthatitreproducestheaccuracyofmorewidelyusedmethodsonatest-setofsmallatomicsystems,thuspavingthewayforthedevelopmentoffast,efficientandaccuratecodesonthisbasis.

简介：Wereportonthefirstmonolithicallyintegratedmicroring-basedopticalswitchintheswitch-and-selectarchitecture.Theswitchfabricdeliversstrictlynon-blockingconnectivitywhilecompletelycancelingthefirst-ordercrosstalk.The4×4switchingcircuitconsistsofeightsiliconmicroring-basedspatial(de-)multiplexersinterconnectedbyaSi/SiNdual-layercrossing-freecentralshuffle.Analysisoftheon-stateandoff-statepowertransferfunctionsrevealstheextinctionratiosofindividualringresonatorsexceeding25dB,leadingtoswitchcrosstalksuppressionofuptoover50dBintheswitch-and-selecttopology.Opticalpathsareassessed,showinglossesaslowas0.1dBperoff-resonanceringand0.5dBperon-resonancering.Photonicswitchingisactuatedwithintegratedmicro-heaterstogivean~24GHzpassband.Thefullypackageddeviceisflip-chipbondedontoaprintedcircuitboardbreakoutboardwithaUV-curvedfiberarray.

简介：Newnon-volatilememory(NVM)technologiesareexpectedtoreplacemainmemoryDRAM(dynamicrandomaccessmemory)inthenearfuture.NANDflashtechnologicalbreakthroughshaveenabledwideadoptionofsolidstatedrives(SSDs)instoragesystems.However,flash-basedSSDs,bynature,cannotavoidlowenduranceproblemsbecauseeachcellonlyallowsalimitednumberoferasures.ThiscangiverisetocriticalSSDreliabilityissues.SincemanySSDwriteoperationseventuallycausemanySSDeraseoperations,reducingSSDwritetrafficplaysacrucialroleinSSDreliability.ThispaperproposestwoNVM-basedbuffercachepolicieswhichcanworktogetherindifferentlayerstomaximallyreduceSSDwritetraffic:amainmemorybuffercachedesignnamedHierarchicalAdaptiveReplacementCache(H-ARC)andaninternalSSDwritebufferdesignnamedWriteTrafficReductionBuffer(WRB).H-ARCconsidersfourfactors(dirty,clean,recency,andfrequency)toreducewritetrafficandimprovecachehitratiosinthehost.WRBreducesblockerasuresandwritetrafficfurtherinsideanSSDbyeffectivelyexploitingtemporalandspatiallocalities.ThesetwocomprehensiveschemessignificantlyreducetotalSSDwritetrafficateachdifferentlayer(i.e.,hostandSSD)byupto3x.Consequently,theyhelpextendSSDlifespanwithoutsystemperformancedegradation.

简介：Objective:Despiteevidencethatestrogensandinsulinareinvolvedinthedevelopmentandprogressionofmanycancers,theirsynergisticroleinendometrialcarcinoma(EC)hasnotbeenanalyzedyet.Methods:Here,weinvestigatedhowestrogensactsynergisticallywithinsulintopromoteECprogression.Cellgrowthinvitroandinvivo,effectsofestradiolandinsulinonapoptosisandcellcycledistribution,andexpressionandactivationofestrogenreceptor(ER),insulinreceptor(InsR),andkeyproteinsinthePI3KandMAPKpathwayswereexaminedaftercombinedstimulationwithestradiolandinsulin.Results:ComparedtoECcellstreatedwithestradiolorinsulinalone,thosetreatedwithbothestradiolandinsulinexhibitedstrongerstimulation.EstradiolsignificantlyinducedphosphorylationofInsR-βandIRS-1,whereasinsulinsignificantlyinducedphosphorylationofER-α.Inaddition,treatmentwithbothinsulinandestradioltogethersignificantlyincreasedtheexpressionandphosphorylationofAkt,MAPK,andERK.Notably,InsR-βinhibitionhadalimitedeffectonestradiol-dependentproliferation,cellcycle,andapoptosis,whereasER-αinhibitionhadalimitedinsulin-dependenteffect,inECcelllines.InsulinandestradiolindividuallyandsynergisticallypromotedECxenograftgrowthinmice.Conclusions:EstrogenandinsulinplaysynergisticrolesinECcarcinogenesisandprogressionbyactivatingInsR-βandER-α,promotingacrosstalkbetweenthem,andtherebyresultingintheactivationofdownstreamPI3K/AktandMAPK/ERKsignalingpathways.

简介：Wepresentherethedevelopmentofcholesterol(Chol)-modifieddendrimersystemfortargetedchemotherapyoffolate(FA)receptor-expressingcancercells.Inourstudy,poly(amidoamine)(PAMAM)dendrimersofgeneration5(G5)werefunctionalizedstepby-stepwithChol,fluoresceinisothiocyanate(FI),andFAviaapoly(ethyleneglycol)(PEG)spacer(PEG-FA),andthenacetamidetoshieldtheirremainingsurfaceamines.ThesynthesizedG5.NHAc-Chol-FI-PEG-FA(forshort,G5-CFPF)dendrimerswereutilizedtoencapsulate10-hydroxycamptothecin(HCP),ahydrophobicanticancerdrug.WefindthateachG5-CFPFdendrimercanencapsulate13.8HCPmolecules.ThecomplexesshowaslowerreleaseprofilesofHCPinapH-dependentmannerthanthecontrolcomplexesformedusingthesamedendrimerswithoutCholunderthesameconditions.ThankstothetargetingroleplayedbyFA,thecomplexesdisplayaspecificinhibitionefficacytoFAreceptor-expressingcervicalcancercells.ThedesignedChol-modifieddendrimersmaybeadoptedasapromisingcarrierforapplicationintargetedcancertherapy.

简介：Theadaptivetreatmenttolerance(ATT)ofcancercellsisthemainencumbrancetocancerchemotherapy.Apotentialsolutiontothisproblemistotreatcancercellswithmultipledrugsusingnanoparticles(NPs).Inthisstudy,wetestedtheco-administrationofcurcumin(Cur)anddoxorubicin(Dox)toMCF-7resistantbreastcancercellstoblocktheATTandelicitefficientcellkilling.Drugswereco-administeredtocellsbothsequentiallyandsimultaneously.Sequentialdrugco-administrationwascarriedoutbypre-treatingthecellswithalbuminnanoparticles(ANPs)loadedw让hCur(Cur@ANPs)followedbytreatmentwithDox-loadedANPs(Dox@ANPs).Simultaneousdrugco-administrationwascarriedoutbytreatingthecellswithANPsloadedwithboththedrugs(Cur/Dox@ANPs).Wefoundthatthesimultaneousdrugco-administrationledtoagreaterintra-cellularaccumulationofDoxandcellkillingwithrespecttothesequentialdrugco-administration.However;thesimultaneousdrugco-administrationledtoalowerintracellularaccumulationofCurwithrespecttothesequentialdrugco-administration.WeshowedthatthisresultwasduetotheaggregationandentrapmentofCurinthelysosomesassoonasitwasreleasedfromCur@ANPs,aphenomenoncalledlysosomotropism.Incontrast,thesimultaneousreleaseofDoxandCurfromCur/Dox@ANPsintothelysosomesledtolysosomalpHelevation,which,inturn,avoidedCuraggregation,ledtolysosomeswellinganddrugreleaseinthecytosol,andfinallyprovokedefficientcellkilling.Ourstudyshedthelightonthemolecularprocessesdrivingthetherapeuticeffectsofanti-cancerdrugsco-administeredtocancercellsindifferentmanners.

简介：Thisstudyinvestigatestheeffectivenessofthenon-smoothsemi-activecontrolalgorithmonsuppressingthevibrationperformanceofabuildingstructuresubjectedtoseismicwaves.AccordingtotheLyapunovstabilitytheory,ithasbeneproventhatthenon-smoothsemi-activecontrolalgorithmcanachieveafinite-timestabilityofthevibrationrelativetotheisolationlayerofabuildingstructure.Throughnumericalsimulationoftwobuildingswithdifferentparameterssubjectedtotheinputofaseismicwave,thevibrationconditionsofpassivecontrol,LQRsemi-activecontrolandnon-smoothsemiactivecontrolarecomparedandanalyzed.Thesimulationresultsshowthatthenon-smoothsemi-activecontrolalgorithmhasabetterrobustnessandeffectivenessinrestrainingtheimpactofearthquakesonthestructure.

简介：Asimpleone-potnon-isocyanaterouteforsynthesizingthermoplasticpolyureasispresented.Insituurethanizationwasconductedfromthering-openingreactionofethylenecarbonatewithpoly(propyleneglycol)bis(2-aminopropylether)andhexanediamine,m-xylylenediamine,ordiethyleneglycolbis(3-aminopropyl)etherat100℃for6hundernormalpressure.Melttransurethanepolycondensationwassuccessivelyconductedat170℃underareducedpressureof399Pafordifferenttimeperiods.Aseriesofnonisocyanatethermoplasticpolyureas(NI-TPUreas)wereprepared.TheNI-TPUreaswerecharacterizedbygelpermeationchromatography,FTIR,1H-NMR,differentialscanningcalorimetry,thermogravimetricanalysis,wide-angleX-raydiffraction,atomicforcemicroscopy,andtensiletest.NI-TPUreasexhibitedMnofupto1.67×10^4g/mol,initialdecompositiontemperatureover290℃,andtensilestrengthofupto32MPa.SeveralcrystallizableNI-TPUreasexhibitedTmexceeding98℃.NI-TPUreaswithgoodthermalandmechanicalpropertieswerepreparedthroughagreenandsimpleone-potnon-isocyanateroute.

简介：TherootbarkofMorusalbaL.orwhitemulberryiswidelyusedastraditionalmedicineinChina,JapanandKorea.Majorclassesandtypesofphenoliccompoundsisolatedfromtherootbarkareflavonoids(kuwanons,morusin,cyclomorusinandsanggenons),benzofurans(moracinsandmulberrofurans),andstilbenoids(mulberrosides).SomeoftheflavonoidsandbenzofuransareproductsofDiel-Aldertypeadducts.Otherclassesofcompoundsincludetriterpenes,phenolicacidsandcoumarins.Morusin,aprenylatedflavonoid,wasfirstisolatedfromtherootbarkofM.alba,andlaterfromtheleaf,stembarkandtwigoftheplant.Thepotentanti-cancerpropertiesofmorusinhaveattractedmuchattentionwithresearchon-goingandnewfindingsbeingpublished.Thecompoundinhibitsangiogenesis,tumourprogressionandtumourmigration,andtriggersapoptosis,cellcyclearrestandautophagyincolorectal,cervical,prostate,breast,hepatoma,pancreatic,glioblastoma,gastric,ovarianandlungcancercelllines.Theanti-canceractivitiesofmorusinareexecutedviavariousmoleculartargetsandsignallingpathways.Itisanticipatedthaton-goinginvitrostudieswillprogressgraduallytoinvivostudiesusinganimalmodelsbeforeeffortstowardsdrugdevelopmentcanbeinitiatedforclinicaltrials.