简介:AbstractPhenuiviridae, a member of the Bunyavirales order, can lead to significant human morbidity and mortality. Various phenuiviruses target specific cellular proteins and have strategies to counteract the effects of type I interferon (IFN). Previous studies have shown that phenuiviruses infection inhibits the synthesis of type I IFNs, and viral nonstructural proteins (NSs) had been further identified as an IFN antagonist. This study found that the NSs proteins of Dabie bandavirus (DBV), Sandfly fever Sicilian virus (SFSV), and Uukuniemi virus (UUKV) can inhibit Sendai virus-induced activation of IFN-β promoter and phosphorylation of IFN regulatory factor 3 (IRF3). Moreover, detailed analysis revealed that the phenuivirus NSs protein could directly interact with retinoic acid inducible gene-I (RIG-I) and degrade it via a proteasome-dependent pathway. In short, this study demonstrate a novel mechanism of phenuiviruses to resist host antiviral immunity, which may help understand these pathogens and suggest novel therapeutic approaches.
简介:摘要:本文基于Oracle Crystal Ball软件,以试验室常用的绝缘电阻表为例,采用不确定度传播率(简称GUM法)和蒙特卡洛法(简称MCM)分别对其测量结果进行不确定度评定,同时,以MCM验证GUM法评定结果的可靠性。
简介:摘要回顾性分析2012年1月至2021年6月期间本中心9例胆囊癌肉瘤患者的临床病理资料。9例患者中8例行根治性手术治疗,5例术后行辅助化疗;1例行腹腔肿瘤活检+化疗+靶向治疗。患者中位生存时间为8个月,最长生存时间为29个月,其中术后行GEMOX方案化疗患者较其他方案化疗患者生存时间长,靶向治疗患者生存时间长达20个月。笔者认为手术切除是治疗胆囊癌肉瘤的最佳手段,术后合理的化疗方案有助于延长患者生存时间,靶向治疗在胆囊癌肉瘤中的疗效有待进一步研究。